Brian Ross, Ph.D.

Roger A Berg M. D. Radiology Research Professor
Professor, Radiology
Professor, Biological Chemistry

2071 BSRB, Box 220

(734) 763-2099

Appointments

Radiology, Medical School
Biological Chemistry, Medical School

Areas of Interest

Molecular imaging is as an exciting area of multidisciplinary research that allows physiology and molecular processes to be visualized in living tissue. Instrumentation involved in molecular imaging includes magnetic resonance imaging (MRI), bioluminescence imaging (BLI), positron emission tomography (PET) and x-ray computer assisted tomography (CT). As part of the Center for Molecular Imaging, we are developing applications for imaging to allow for investigations of cancer growth and response to therapy including noninvasive detection of molecular signaling events in living tissue. Translation of developed algorithms into the clinical setting are ongoing.

Honors & Awards

International 1998 Invited Plenary Lecture at the First International Meeting of Gene Imaging, Greece
1999 Invited Plenary Lecture at the Second International Meeting of Gene Imaging, Greece.
2009 Elected as a Fellow of the ISMRM
2011 Outstanding Teaching Award - ISMRM Montreal, Canada
2014 Outstanding teaching Award – ISMRM Milan, Italy

National 1987-1990 Research Fellow of the Association for Brain Tumor Research
2001-2003 Elected Treasurer of the Society for Molecular Imaging
2004 Elected President-Elect of Society for Molecular Imaging
2005 Elected President of Society for Molecular Imaging
2013 Distinguished Investigator of the Academy of Radiology Research

Institutional 1987-90 Research Fellowship from the Association for Brain Tumor Research
2004 Chandran Lecture at Duke University, North Carolina
2012-present Endowed Professorship, Roger A. Berg Research Professor of Radiology, University of Michigan

Editorial & Board Positions
1998-2008 Founding Editor, Neoplasia
2002-2005 Executive Editor, Molecular Imaging, The official journal of the Society for Molecular Imaging
2004-2007 Member of the Advisory Panel of the American College of Radiology Imaging Network
2007-12 Cancer Research UK Cambridge Research Institute Member Scientific Advisory Board

Published Articles or Reviews

Chenevert TL, Stegman LD, Taylor JMG, Robertson PL, Greenberg HS, Rehemtulla A, and Ross BD. Diffusion magnetic resonance imaging: an early surrogate marker of therapy efficacy in brain tumors. J Natl Cancer Inst. 2000 92(24): 2029-2036. PMID: 11121466.

Moffat BA, Chenevert TL, Lawrence TS, Meyer CR, Johnson TD, Dong Q, Tsien C, Mukherji S, Quint DJ, Gebarski SS, Robertson PL, Junck LR, Rehemtulla A, Ross BD. Functional diffusion map: a noninvasive MRI biomarker for early stratification of clinical brain tumor response. Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5524-9. PMID 555936.

Galbán CJ, Chenevert TL, Meyer CR, Tsien C, Lawrence TS, Hamstra DA, Junck L, Sundgren PC, Johnson TD, Ross DJ, Rehemtulla A, Ross BD. The parametric response map is an imaging biomarker for early cancer treatment outcome. Nat Med. 2009 May;15(5):572-6. PMID: 3307223.

Zhang L, Virani S, Zhang Y, Bhojani MS, Burgess TL, Coxon A, Galban CJ, Ross BD, Rehemtulla A: Molecular Imaging of c-Met Kinase Activity Anal Biochem. 2011 May 1;412(1):1-8. PMID: 21276769.

Hoff BA, Kozloff KM, Boes JL, Brisset JC, Galbán S, Van Poznak CH, Jacobson JA, Johnson TD, Meyer CR, Rehemtulla A, Ross BD, Galbán CJ: Parametric response mapping of CT images provides early detection of local bone loss in a rat model of osteoporosis. Bone 51(1): 78-84, 2012. PMID: 22542461.

Galbán CJ, Han MK, Boes JL, Chughtai KA, Meyer CR, Johnson TD, Galbán S, Rehemtulla A, Kazerooni EA, Martinez FJ, Ross BD. Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression. Nat Med. 2012 Oct 7. doi: 10.1038/nm.2971. PMID: 23042237.

Galbán S, Jeon YH, Bowman BM, Stevenson J, Sebolt KA, Sharkey LM, Lafferty M, Hoff BA, Butler BL, Wigdal SS, Binkowski BF, Otto P, Zimmerman K, Vidugiris G, Encell LP, Fan F, Wood KV, Galbán CJ, Ross BD, Rehemtulla A: Imaging Proteolytic Activity in Live Cells and Animal Models PLoS ONE 8(6): 2013. PMID: 23776643

Galbán CJ, Boes JL, Bule M, Kitko CL, Couriel DR, Johnson TD, Lama V, Telenga ED, van den Berge M, Rehemtulla A, Kazerooni EA, Ponkowski MJ, Ross BD, Yanik GA. Parametric Response Mapping as an Indicator of Bronchiolitis Obliterans Syndrome after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2014 Jun 18. pii: S1083-8791(14)00364-4. doi: 10.1016/j.bbmt.2014.06.014. [Epub ahead of print]. PMID: 24954547.