Assistant Professor of Biological Chemistry
[email protected]
Available to mentor
Yan Zhang
Assistant Professor
The overarching goal of my lab is (i) to decipher the fascinating biology of diverse CRISPR-Cas systems in bacteria, and (ii) to convert their novel features into new biotechnologies and gene therapy strategies for treating human diseases. We use a multidisciplinary approach blending cell biology, genetics, biochemistry, next-generation sequencing, bioinformatics, and animal models to uncover brand-new CRISPR systems from nature, invent gene-editing tools, and leverage CRISPR therapeutics to tackle a wide range of genetic disorders.
https://yanzhanglab.med.umich.edu/
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Geslewitz WE, Cardenas A, Zhou X, Zhang Y, Criss AK, Seifert HS. mBio, 2024 Feb 14; 15 (2): e0302523Journal ArticleDevelopment and implementation of a Type I-C CRISPR-based programmable repression system for Neisseria gonorrhoeae.
DOI:10.1128/mbio.03025-23 PMID: 38126782 -
Hu C, Myers MT, Zhou X, Hou Z, Lozen ML, Nam KH, Zhang Y, Ke A. Mol Cell, 2024 Feb 1; 84 (3): 463 - 475.e5.Journal ArticleExploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.
DOI:10.1016/j.molcel.2023.12.034 PMID: 38242128 -
Hou Z, Tan R, Zhang Y. Trends Biochem Sci, 2023 Jan; 48 (1): 9 - 10.Journal ArticleSnapshots of a tiny ancestral nuclease of Cas9.
DOI:10.1016/j.tibs.2022.08.008 PMID: 36100522 -
Tan R, Krueger RK, Gramelspacher MJ, Zhou X, Xiao Y, Ke A, Hou Z, Zhang Y. Mol Cell, 2022 Feb 17; 82 (4): 852 - 867.e5.Journal ArticleCas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems.
DOI:10.1016/j.molcel.2021.12.032 PMID: 35051351 -
Hou Z, Hu C, Ke A, Zhang Y. Curr Protoc, 2022 Feb; 2 (2): e361Journal ArticleIntroducing Large Genomic Deletions in Human Pluripotent Stem Cells Using CRISPR-Cas3.
DOI:10.1002/cpz1.361 PMID: 35129865 -
Gramelspacher MJ, Hou Z, Zhang Y. Methods, 2020 Feb 1; 172: 32 - 41.Journal ArticleBiochemical characterization of RNA-guided ribonuclease activities for CRISPR-Cas9 systems.
DOI:10.1016/j.ymeth.2019.06.018 PMID: 31228550 -
Dolan AE, Hou Z, Xiao Y, Gramelspacher MJ, Heo J, Howden SE, Freddolino PL, Ke A, Zhang Y. Mol Cell, 2019 Jun 6; 74 (5): 936 - 950.e5.Journal ArticleIntroducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas.
DOI:10.1016/j.molcel.2019.03.014 PMID: 30975459 -
Hou Z, Zhang Y. Science, 2019 Jul 5; 365 (6448): 25 - 26.Journal ArticleInserting DNA with CRISPR.
DOI:10.1126/science.aay2056 PMID: 31273110
Department News
Assistant Professor Yan Zhang of the Department of Biological Chemistry at U-M Medical School is the recipient of an NSF CAREER award.
Department News
PhD student Mason Myers of the Zhang lab at U-M Medical School is a lead author of "Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications."
Department News
Yan Zhang lab receives Research Scouts Award for collaborative project
