Vasantha Padmanabhan

Vasantha Padmanabhan, MS, PhD

Professor, Pediatrics and Communicable Diseases
Professor, OB-Gyn
Professor, Molecular & Integrative Physiology
Professor, Department of Environmental Health Sciences

Areas of Interest

Selected Publications:

Padmanabhan V, Veiga-Lopez A, Abbott DH, Recabarren SE, Herkimer C 2010 Developmental programming: Impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females. Endocrinology 151:595-605; PMCID: PMC2817622

Abi-Salloum B, Herkimer C, Lee JS, Veiga-Lopez A, Padmanabhan V 2012 Developmental programming: prenatal and postnatal contribution of androgens and insulin in the reprogramming of estradiol positive feedback disruptions in prenatal testosterone-treated sheep. Endocrinology 153:2813-2822. PMCID: PMC3359592

Veiga-Lopez A, Luense LJ, Christenson LK, Padmanabhan V 2013 Developmental programming: gestational bisphenol-A treatment alters fetal ovarian gene expression. Endocrinology 154: 1873–1884. PMCID: PMC3628019,

Padmanabhan V, Veiga-Lopez A, Herkimer C, Abi Salloum B, Moeller J, Beckett E, Sreedharan R 2015 Developmental programming: prenatal and postnatal androgen antagonist and insulin sensitizer interventions prevent advancement of puberty and improve LH surge dynamics in prenatal testosterone-treated sheep. Endocrinology 156(7):2678-92. PMCID: PMC4475717;

Veiga-Lopez A, Kannan K, Liao C, Ye W, Domino S, Padmanabhan V 2015 Gender-specific effects on gestational length and birth weight by early pregnancy BPA exposure. Journal of Clin Endocrinol Metab. 100(11):E1394-403. PMCID:PMC4702459;

Cardoso RC, Veiga-Lopez A, Moeller J, Beckett E, Pease A, Keller E, Madrigal V, Chazenbalk G, Dumesic D, Padmanabhan V 2016 Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep.. Endocrinology. Endocrinology 157:522-535 PMCID:PMC4733129

Lu C, Cardoso RC, Puttabyatappa M, Padmanabhan V 2016 Developmental Programming: Prenatal Testosterone Excess and Insulin Signaling Disruptions in Female Sheep. Biology of Reproduction 94(5):113, 1-11. PMCID:PMC4939741;

Marchlewicz EH, Dolinoy DC, Tang L, Milewski, Jones TR, Goodrich JM, Soni T, Domino SE, Song PXK, Burant C, Padmanabhan V 2016 Lipid metabolism is a key mediator of developmental epigenetic programming. Scientific Reports 2016 Oct 7; 6:34857. PMCID:PMC5054359

Koneva LA, Vyas AK, Deng J, McEachin RC, Medvedovic M, Puttabyatappa M, Gao X, Wang H-S, Sartor MA, Padmanabhan V 2017 Developmental programming: interaction between prenatal BPA and postnatal overfeeding on cardiac tissue gene expression in female sheep. Environ Mol Mutagen. 2017 Jan;58(1):4-18. doi: 10.1002/em.22071. Epub 2017 Jan 12. PMCID: PMC5730970

Puttabyatappa M, Andriessen V, Mesquitta M, Zeng L, Pennathur S, Sauerwein H, Padmanabhan V 2017 Developmental programming: impact of gestational steroid and metabolic milieus on mediators of insulin sensitivity in prenatal testosterone-treated female sheep. Endocrinology 158:2783-2798. PMCID: PMC5659659.

Montrose L, Padmanabhan V, Goodrich JM, Domino SE, Treadwell MC, Meeker JD, Watkins, DJ, Dolinoy DC 2018 Maternal levels of endocrine disrupting chemicals in the first trimester of pregnancy are associated with infant cord blood DNA methylation. Epigenetics 13(3):301-309. PMCID: PMC5997152

Goodrich JM, Ingle ME, Domino SE, Treadwell MC, Dolinoy DC, Burant C, Meeker JD, Padmanabhan V  2019 First trimester maternal exposures to endocrine disrupting chemicals and metals and fetal size in the Michigan Mother-Infant Pairs study. J Dev Orig Health Dis. 2019 Jan 30:1-12. doi: 10.1017/S204017441800106X. [Epub ahead of print] PMID: 30696509

Kelley AS, Banker M, Goodrich JM, Dolinoy DC, Burant C, Domino S, Smith YR, Song PXK, Padmanabhan V 2019 Early pregnancy exposure to endocrine disrupting chemical (EDC) mixtures are associated with inflammatory changes in maternal and fetal circulation.  Sci Rep. 9(1):5422. doi: 10.1038/s41598-019-41134-z.  PMCID:PMC644377