Donna Johns 734-936-5047
Areas of Interest
My research centers on the molecular and cellular biology of lung injury, inflammation, immunity, repair, and fibrosis. Using normal cells, cells from diseased patients, and animal models of disease, we study the biology of lung macrophages and other immune cells, epithelial cells, and fibroblasts. We are particularly interested in receptors, mediators, cell signaling, and transcriptional programs that control cell fate and function. Ongoing projects include: 1) the role of extracellular vesicles as vectors for cell-cell communication in the lung; 2) mechanisms controlling alveolar macrophage proliferation; 3) the role of macrophages in allergic inflammation; 4) transcriptional programs in fibroblasts that govern proliferation, collagen synthesis, and myofibroblast differentiation. Our ultimate goal is to gain novel insights into lung homeostasis and disease pathogenesis, and to identify new strategies for therapeutic targeting. Mentoring is an important focus of mine, and my laboratory consists of a highly interactive and collaborative group of M.D. and Ph.D. trainees from around the world.
I enjoy caring for patients with the full gamut of lung diseases. Areas of particular interest include asthma, COPD, and interstitial lung disorders.
A profile is available at the U of M Health site.
M.D., 1978, Duke University School of Medicine
1978-1981, Tufts-New England Medical Center
Pulmonary Medicine And Environmental Health Sciences, 1983, Johns Hopkins University Pulmonary Medicine, 1984, Johns Hopkins University
1981, Internal Medicine 1984, Pulmonary Diseases 1988, Critical Care Medicine
Faculty Appointment Date