June 3, 2014

PETAL Awarded



Clinical Centers for the NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Clinical Trials Network

The University of Michigan has been selected as one of the Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Clinical Trials Network (U01).  This network represents the extension of the ARDS Clinical Network developed to perform multi-site clinical trials in patients with ARDS.  


The PETAL Network represents a change in focus of ARDS clinical trials, with an emphasis on therapies to prevent ARDS in high risk patients, and for early identification and intervention in patients with established ARDS.   The new network also emphasizes multidisciplinary teams, including active engagement of investigators from the Emergency Medicine Department.  The University of Michigan is one of twelve clinical sites throughout the country, and will be led by Robert Hyzy, M.D.  from the Division of Pulmonary and Critical Care Medicine.  Other key investigators include Theodore Standiford, M.D. (Division of Pulmonary and Critical Care Medicine), Pauline Park, M.D. (Department of Surgery), and Kyle Gunnerson, M.D. (Department of Emergency Medicine).  The U01 provides resources to perform 4-6 clinical trials over a seven year period of funding.  Investigators at the University of Michigan have proposed two clinical trials; the first assessing the impact of growth factor administration (GM-CSF) on clinical outcomes in patients at risk for or with early ARDS, and the second trial assessing the impact of macrolide administration (azithromycin) on outcome in patients with early onset ARDS.  The studies proposed will also afford the opportunity to perform molecular phenotyping of patients to correlate with treatment responses, as well as assess  the influence of specific therapies on the lung microbiome during ARDS.  Funding will begin in August of this year, and it is anticipated that clinical trials will begin the following year.   

For more information, contact Dr. Robert Hyzy.

Robert C. Hyzy, M.D.

Professor, Department of Internal Medicine
Director, Critical Care Medicine Unit
Phone: Taubman Center (734) 763-7668 Appts x2 Nurse x5

Theodore J. Standiford, M.D.

Chief, Division of Pulmonary and Critical Care Medicine
Program Director, T32 Multidisciplinary Training Program in Lung Diseases
Pulmonary Appointments: (888) 287-1084 or (734) 647-9342 x2, Nurses: (734) 936-5549 x7 // Scientific Issues: 734-764-4554; Division Administration: 734-936-5010

Theodore Iwashyna, Ph.D., M.D.

Associate Professor, Department of Internal Medicine
Faculty Associate, Survey Research Center, Institute for Social Research
Research Scientist, Center for Clinical Management Research, Ann Arbor VA HSR&D
Co-Director, Robert Wood Johnson Foundation Clinical Scholars Program
Phone: 734-936-5047

Gary Huffnagle, Ph.D.

Professor, Dept. of Internal Medicine
Professor, Dept. of Microbiology and Immunology
Associate Director, T32 Multidisciplinary Training in Pulmonary Diseases
Phone: 734-936-7934

Kyle Gunnerson, M.D.

Associate Professor, Emergency Medicine
Director, Emergency Critical Care Center
(734) 763-2134
Pauline K. Park, M.D.
Professor of Surgery