Y. Eugene Chen, M.D., Ph.D

Frederick Huetwell Professor of Cardiovascular Medicine
Vice-Chair for Basic and Translational Research, Department of Cardiac Surgery
Director, Center for Advanced Models for Translational Sciences and Therapeutics
University of Michigan Medical Center

Dr. Eugene Chen is the endowed Frederick Huetwell Professor of Cardiovascular Medicine at the University of Michigan Medical Center, and also serves as Associate Chair for Research. Dr. Chen graduated from The Third Military Medical University in Chongqing, China with a Bachelor’s degree in Medicine in 1985. He obtained his M.Sc. degree in Biochemistry from The Academy of Military Medical Sciences in 1988, and his Doctor of Philosophy in Molecular Genetics from the University of Western Ontario in 1995. After his postdoctoral training at the University of Toronto and Harvard Medical School, Dr. Chen became an Assistant Professor of Biochemistry at the Cardiovascular Research Institute within Morehouse School of Medicine in 1999. In 2005, Dr. Chen moved to the Cardiovascular Center at the University of Michigan as a tenured Associate Professor of Internal Medicine. 

The long-term goal of Dr. Chen’s research program in vascular medicine is elucidating the molecular basis of obesity/diabetes-induced cardiovascular diseases (CVD) and stroke, and on developing new drugs/technologies to study and treat diabetes and CVD.  In the past years, Dr. Chen’s laboratory has made a series of significant contributions to the understanding of the role of peroxisome proliferator-activated receptors (PPARs) activation as a determinant of vascular cell gene expression and cellular function, and has been among the first to define the role of PPAR activation in the cardiovascular system. The discovery of the high affinity physiological PPAR ligands, nitro-fatty acids advances understanding of endogenous PPAR modulation and provides novel therapeutic strategies for treating obesity/diabetes and CVD. Dr. Chen was the first one to clone the exendin-4 (BYETTA, the drug name for Exendin-4) gene in 1995. 

Contact Information:
Y. Eugene Chen, M.D., Ph.D.
NCRC Building 26, Room 361S
2800 Plymouth Road
Ann Arbor, MI 48109-2800
734-763-7097 fax
Email: echenum@med.umich.edu