Protein Folding Diseases Initiative

Composite image of scientific illustrations of protein folding diseases


The Protein Folding Diseases (PFD) Initiative connects diverse campus-wide expertise on disorders of abnormal protein accumulation and perturbations in “protein quality control.”

This growing list of diseases numbers more than a hundred, with diseases affecting nearly all organ systems and ranging from some of the most common acquired disorders to a wide array of hereditary diseases.

Many PFD disorders are poorly understood, untreatable and often fatal. Accordingly, the unmet needs are tremendous. As one example, more than 5 million people in the U.S. now suffer from Alzheimer’s disease and, as our population ages, this number will climb rapidly.

Similarly, for cancer treatment, the regulation of protein degradation has emerged as an important target with profound therapeutic implications.

A better understanding of disease mechanisms and more effective therapies is needed for nearly all PFD disorders. The programs developed by the PFD Initiative promise to accelerate the path to new mechanistic insights and improved treatments for these diseases.


***Now Available in the Resource Center - Antibodies in Reagent Library***




Seminar Series


October 1, 2015

Erika Holzbaur

 Erika Holzbaur, Ph.D.

 Talk Title Forthcoming

3:00 PM - 4:30 PM

BSRB Seminar Rooms A, B, C





2nd Annual PFDI Symposium - "Molecules and Machines"

Save the Date

 Friday, September 18, 2015

9:00 am until 5:00 pm

A. Alfred Taubman Biomedical Science Research Building

Judith Frydman, Ph.D., Stanford University, Tom Rapoport, Ph.D., Harvard Medical School, Franz-Ulrich Hartl, Ph.D., Max Planck Institute of Biochemistry




PFDI Related Talks


December 9, 2015

William E. Balch

Neurology Grand Rounds

William E. Balch, Ph.D.