Protein Folding Diseases Initiative

Composite image of scientific illustrations of protein folding diseases

 

The Protein Folding Diseases (PFD) Initiative connects diverse campus-wide expertise on disorders of abnormal protein accumulation and perturbations in “protein quality control.”

This growing list of diseases numbers more than a hundred, with diseases affecting nearly all organ systems and ranging from some of the most common acquired disorders to a wide array of hereditary diseases.

Many PFD disorders are poorly understood, untreatable and often fatal. Accordingly, the unmet needs are tremendous. As one example, more than 5 million people in the U.S. now suffer from Alzheimer’s disease and, as our population ages, this number will climb rapidly.

Similarly, for cancer treatment, the regulation of protein degradation has emerged as an important target with profound therapeutic implications.

A better understanding of disease mechanisms and more effective therapies is needed for nearly all PFD disorders. The programs developed by the PFD Initiative promise to accelerate the path to new mechanistic insights and improved treatments for these diseases.

 

Events

 

Seminar Series

 

December 4, 2014

William Dauer

 William T. Dauer, M.D.

"Why Bad Proteins Happen to Good Neurons:  Sensorimotor Circuit Neurodegeneration in Dystonia"

3:00 PM - 4:30 PM

2515 BSRB

 

 

 

2nd Annual PFDI Symposium - "Molecules and Machines"

Save the Date

 Friday, September 18, 2015

9:00 am until 4:30 pm

A. Alfred Taubman Biomedical Science Research Building

Judith Frydman, Ph.D., Stanford University, Tom Rapoport, Ph.D., Harvard Medical School, Franz-Ulrich Hartl, Ph.D., Max Planck Institute of Biochemistry

 

 

 

PFDI Related Talks

 

February 11, 2014

Dennis Selkoe

 Neurology Grand Rounds

Dennis J. Selkoe, M.D.

10:30 AM - 11:30 AM

Danto Auditorium, Cardiovascular Center

 

 

 

April 1, 2014

William E. Balch

Neurology Grand Rounds

William E. Balch, Ph.D.