Protein Folding Diseases Initiative

Composite image of scientific illustrations of protein folding diseases


The Protein Folding Diseases (PFD) Initiative connects diverse campus-wide expertise on disorders of abnormal protein accumulation and perturbations in “protein quality control.”

This growing list of diseases numbers more than a hundred, with diseases affecting nearly all organ systems and ranging from some of the most common acquired disorders to a wide array of hereditary diseases.

Many PFD disorders are poorly understood, untreatable and often fatal. Accordingly, the unmet needs are tremendous. As one example, more than 5 million people in the U.S. now suffer from Alzheimer’s disease and, as our population ages, this number will climb rapidly.

Similarly, for cancer treatment, the regulation of protein degradation has emerged as an important target with profound therapeutic implications.

A better understanding of disease mechanisms and more effective therapies is needed for nearly all PFD disorders. The programs developed by the PFD Initiative promise to accelerate the path to new mechanistic insights and improved treatments for these diseases.




1st Annual Protein Folding Diseases Symposium - Protein Quality Control Pathways and Disease

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Friday, September 19, 2014

A. Alfred Taubman Biomedical Science Research Building, Kahn Auditorium and Seminar Rooms A, B, C

8:30 am - 4:00 pm


Keynote Speakers:

Rick Morimoto, Ph.D., Bill and Gayle Cook Professor of Biology, Director of the Rice Institute for Biomedical Research, Northwestern University, "Organismal Proteostasis: Intertissue Stress in Development and Aging"
Nancy Bonini, Ph.D., Professor of Biology, Investigator of the Howard Hughes Medical Institute, University of Pennsylvania, "Human Neurodegenerative Disease: Insights from the Model System Drosophila"
Jason Gestwicki, Ph.D., Associate Professor, University of California, San Francisco, "Chemical Approaches to Understanding Protein Homeostasis and Disease"
See the Full Day's Agenda
Refreshments and Lunch Provided - Registration Required - Register Now!
Please register by September 5, 2014
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