The Protein Folding Diseases (PFD) Initiative connects diverse campus-wide expertise on disorders of abnormal protein accumulation and perturbations in “protein quality control.”
This growing list of diseases numbers more than a hundred, with diseases affecting nearly all organ systems and ranging from some of the most common acquired disorders to a wide array of hereditary diseases.
Many PFD disorders are poorly understood, untreatable and often fatal. Accordingly, the unmet needs are tremendous. As one example, more than 5 million people in the U.S. now suffer from Alzheimer’s disease and, as our population ages, this number will climb rapidly
Similarly, for cancer treatment, the regulation of protein degradation has emerged as an important target with profound therapeutic implications
A better understanding of disease mechanisms and more effective therapies is needed for nearly all PFD disorders. The programs developed by the PFD Initiative promise to accelerate the path to new mechanistic insights and improved treatments for these diseases.
***Now Available in the Resource Center - Antibodies in Reagent Library***
2nd Annual PFDI Symposium - "Molecules and Machines"
Friday, September 18, 2015, 9:00 am until 5:00 pm
A. Alfred Taubman Biomedical Science Research Building, Kahn Auditorium and Seminar Rooms A, B, C
See the Day's Schedule
Click abstract for submission format and procedures
Franz-Ulrich Hartl, Ph.D., Managing Director of the Max Planck Institute of Biochemistry, Germany, "Mechanisms of Aggregate Toxicity and Their Modulation by Molecular Chaperones"
Judith Frydman, Ph.D., Professor, Biology and Genetics, Stanford University, "Chaperone Mediated Proteostasis in Health and Disease"
Tom A. Rapoport, Ph.D., Professor of Cell Biology, Howard Hughes Medical Institute Investigator, Harvard Medical School, "How the ER Gets Into Shape"
We will also have presentations from these University of Michigan Faculty:
Catherine A. Collins, Ph.D., Associate Professor, Molecular, Cellular and Developmental Biology
Daniel R. Southworth, Ph.D., Assistant Professor, Biological Chemistry
Billy Tsai, Ph.D., Corydon Ford Professor, Cell and Developmental Biology
Kristen J. Verhey, Ph.D., A. Kent Christensen Collegiate Professor, Cell and Developmental Biology
October 1, 2015
Erika Holzbaur, Ph.D.
Talk Title Forthcoming
3:00 PM - 4:30 PM
BSRB Seminar Rooms A, B, C
PFDI Related Talks
December 9, 2015
Neurology Grand Rounds
William E. Balch, Ph.D.