The Protein Folding Diseases (PFD) Initiative connects diverse campus-wide expertise on disorders of abnormal protein accumulation and perturbations in “protein quality control.”
This growing list of diseases numbers more than a hundred, with diseases affecting nearly all organ systems and ranging from some of the most common acquired disorders to a wide array of hereditary diseases.
Many PFD disorders are poorly understood, untreatable and often fatal. Accordingly, the unmet needs are tremendous. As one example, more than 5 million people in the U.S. now suffer from Alzheimer’s disease and, as our population ages, this number will climb rapidly
Similarly, for cancer treatment, the regulation of protein degradation has emerged as an important target with profound therapeutic implications
A better understanding of disease mechanisms and more effective therapies is needed for nearly all PFD disorders. The programs developed by the PFD Initiative promise to accelerate the path to new mechanistic insights and improved treatments for these diseases.
***Now Available in the Resource Center - Antibodies in Reagent Library***
December 3, 2015
Vincent Groppi, Ph.D.
"Leveraging the Resources of CDNM to Accelerate the Discovery of New Therapeutics to Treat Protein Folding Diseases"
3:00 PM - 4:30 PM
3rd Annual Protein Folding Diseases Initiative Symposium
Friday, September 23, 2016
PFDI Related Talks
December 9, 2015
Neurology Grand Rounds
William E. Balch, Ph.D.
"Adaptive Management of (Mis)Folding in Degenerative Diseases"
10:30 - 11:30 am
Danto Auditorium @ CVC