Protein Folding Diseases Initiative

Composite image of scientific illustrations of protein folding diseases


The Protein Folding Diseases (PFD) Initiative connects diverse campus-wide expertise on disorders of abnormal protein accumulation and perturbations in “protein quality control.”

This growing list of diseases numbers more than a hundred, with diseases affecting nearly all organ systems and ranging from some of the most common acquired disorders to a wide array of hereditary diseases.

Many PFD disorders are poorly understood, untreatable and often fatal. Accordingly, the unmet needs are tremendous. As one example, more than 5 million people in the U.S. now suffer from Alzheimer’s disease and, as our population ages, this number will climb rapidly

Similarly, for cancer treatment, the regulation of protein degradation has emerged as an important target with profound therapeutic implications

A better understanding of disease mechanisms and more effective therapies is needed for nearly all PFD disorders. The programs developed by the PFD Initiative promise to accelerate the path to new mechanistic insights and improved treatments for these diseases.


***Now Available in the Resource Center - Antibodies in Reagent Library***




Seminar Series

December 3, 2015

Vincent Groppi

 Vincent Groppi, Ph.D.

"Leveraging the Resources of CDNM to Accelerate the Discovery of New Therapeutics to Treat Protein Folding Diseases"

3:00 PM - 4:30 PM

2515 BSRB



Save the Date


 3rd Annual Protein Folding Diseases Initiative Symposium

Friday, September 23, 2016




PFDI Related Talks



December 9, 2015

William E. Balch

 Neurology Grand Rounds

William E. Balch, Ph.D.

"Adaptive Management of (Mis)Folding in Degenerative Diseases"

 10:30 - 11:30 am

Danto Auditorium @ CVC