Research performed within the Division of PCCM has greatly impacted our understanding of basic lung biology, disease pathogenesis, and targeted therapeutics. NIH grant funding for research within the Division exceeds 13 million dollars annually. The divisional investigative portfolio is comprehensive, with specific areas of emphasis including pulmonary inflammation, injury, repair, and fibrosis, host defense, lung transplantation and lung cancer. New major areas of modern biology have emerged, including genetics/genomics, metagenomics, proteomics, metabolomics, stem cell biology, computational biology, and the microbiome. Interactive groups of investigators with interests in fibrotic lung diseases, acute lung injury, and chronic obstructive pulmonary diseases have active, productive clinical investigative programs. Researchers in the division participate in large multidisciplinary and multicenter disease-specific programs and networks in interstitial lung disease (IPFnet, COMET, LTRC), COPD (SPIROMICS, COPD gene, LTRC) and Acute Lung Injury (SCOR, SCCOR, ARDSnet). Emerging fields of patient-oriented research have been added or expanded, including health services research and sleep. Active areas of health services research include long-term functional outcomes in survivors of critical illness, nosocomial infection, delirium in the ICU, health care utilization, and health care policy.