May 5, 2016

Anesthesiology department leads enterprise genomics study on more than 30,000 patients

Two anesthesiologists lead initiative to cultivate and utilize data to better understand genetic associations of disease development.  

The Michigan Genomics Initiative (MGI) is a collaborative research effort among physicians and researchers at the University of Michigan, with the goal of integrating patient electronic medical records with genetic data to gain novel biomedical insights. The initiative is led by Chad Brummett, M.D., director of pain research and clinical anesthesia research and Sachin Kheterpal, M.D., MBA, principal investigator of the Multicenter Perioperative Outcomes Group (MPOG) and the U-M research data warehouse with Gonçalo Abecasis, Ph.D., chair of the U-M Department of Biostatistics.

Using an opt-in, patient-centric informed consent, MGI collects pertinent patient information from electronic health records, biospecimen samples and self-reported questionnaires in order to create a complete picture of each participant's health, disease, exposures, treatment and outcomes. Together, Dr. Brummet and Dr. Kheterpal are leading a high-scale recruitment effort to consent and derive meaningful health information and data from patients. Data that is currently being used and benefited from a variety of studies at UM, including cardiovascular disease, diabetes, pneumonia, cancer, kidney injury, sepsis and pain.

By choosing to participate in the MGI program, patients play a key role in collaborating with physicians to provide vital insights to disease development, response to treatment and drug development. Through further collaboration with world-class geneticists and bioinformaticians, MGI is poised to link genotype and perioperative phenotype in an essential and unprecedented way to better understand and revolutionize how diseases are treated.

Click here for more information about the Michigan Genomics Initiative.

Chad Brummett, M.D.

Director of Clinical Anesthesia Research
Director of Pain Research

Sachin Kheterpal, M.D., MBA

Director of Perioperative Outcomes Research
Director of Strategic Planning