Clinical Research

Clinical Research in the Department of Anesthesiology has undergone tremendous development and achieved international recognition in the past five to ten years. Although the department has traditionally had a number of strong subspecialty research teams, we have more recently developed unique clinical research infrastructures that position us to be at the forefront of clinical research in the fields of perioperative medicine, pain medicine and beyond. Our efforts are primarily focused in the following areas:

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Retrospective Database Research

Without question, the Department of Anesthesiology at the University of Michigan is the international leader in the field of perioperative database research. We are at the epicenter of a data-sharing organization that is second to none. This network has access to data from more than one million surgical patients, thus an unparalleled resource for clinicians and clinical researchers Furthermore, we play a prominent institutional and regional role in database research that extends far beyond the field of anesthesiology. This area of our research is in large part driven by the vision of Dr. Kevin Tremper and Dr. Sachin Kheterpal.

Prospective Interventional Research

The U-M Department of Anesthesiology has also been credited with ground-breaking advances in comparative effectiveness research. Recruiting and randomizing more than twenty thousand patients in two years and across three hospitals, we have led what is arguably the largest single-center effectiveness trial in the history of anesthesiology. This study, the Michigan Awareness Control Study, set a new benchmark for clinical trials in perioperative medicine, especially through its use of real-time decision support. This study, as well as this entire area of our research, is in large part driven by Dr. George Mashour.

Prospective Observational and Genetic Research

The infrastructure of prospective trial research is transformed through NIH-funded studies on the genetics of pain. One of the most sophisticated of its kind, the Analgesic Outcomes Study has led to a major institutional role for the Department of Anesthesiology in the Michigan Genomics Initiative. We have collected almost thirty thousand samples of genetic material with the unique advantage of informed consent that allows for longitudinal follow-up. Through collaboration with world-class geneticists and bioinformaticians, we will be poised to link genotype and perioperative phenotype in an unprecedented way. This area of our research was largely transformed by Dr. Chad Brummett, featured below.

Chad Brummett, M.D.
Director of Clinical Research
Director of Pain Research