Stephan Frangakis, MD, PhD
Assistant Professor of Anesthesiology
[email protected]

Available to mentor
Stephan Frangakis, MD, PhD
Assistant Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • Qualifications
    • Fellowship
      Duke University Hospital, Regional Anesthesiology and Acute Pain Medicine, Department of Anesthesiology, 2021
    • Residency
      Duke University Hospital, Clinical Anesthesiology Department of Anesthesiology, 2020
    • Clinical Internship
      Duke University Hospital, Department of Anesthesiology, 2017
    • M.D.
      Duke University School of Medicine, Durham, North Carolina, 2016
    • Ph.D.
      Duke University School of Medicine, Durham, North Carolina, 2015
    • B.A.
      Rutgers, The State University of New Jersey, New Brunswick, 2006
    Center Memberships
    • Center Member
      Precision Health Initiative
    Research Overview

    My research interests include genetic and physiologic factors predisposing to the development of acute postoperative pain, and the transition to chronic postoperative pain. Additionally, I am interested in adjuvants and techniques to prevent postoperative pain.

    Recent Publications See All Publications
    • Preprint
      Clinical consequences of a polygenic predisposition to benign lower white blood cell counts: Consequences of benign WBC count genetics.
      Mosley JD, Shelley JP, Dickson AL, Zanussi J, Daniel LL, Zheng NS, Bastarache L, Wei W-Q, Shi M, Jarvik GP, Rosenthal EA, Khan A, Sherafati A, Kullo IJ, Walunas TL, Glessner J, Hakonarson H, Cox NJ, Roden DM, Frangakis SG, Vanderwerff B, Stein CM, Van Driest SL, Borinstein SC, Shu X-O, Zawistowski M, Chung CP, Kawai VK. 2023 Aug 21; DOI:10.1101/2023.08.20.23294331
      PMID: 37662324
    • Presentation
      Using Electronic Health Records to Generate algorithm Phenotypes for Chronic Post-Surgical Pain (CPSP)
      Frangakis S. 2023 May 31;
    • Presentation
      The Duke Anesthesiology Social Safety Net; A Quality-Improvement Project Aimed at Boosting Resident Well-being and Morale
      Frangakis S. 2020 Mar;
    • Presentation
      β-Blockers for the Prevention of Acute Postsurgical Pain” Duke Division of Spine Surgery Quarterly Meeting
      Frangakis S. 2020 Mar;
    • Presentation
      The Emerging Role of β-Blockers for the Treatment of Acute and Chronic Pain
      Frangakis S. 2019 Jan;
    • Journal Article
      The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction.
      Abraham DM, Lee TE, Watson LJ, Mao L, Chandok G, Wang H-G, Frangakis S, Pitt GS, Shah SH, Wolf MJ, Rockman HA. J Clin Invest, 2018 Nov 1; 128 (11): 4843 - 4855. DOI:10.1172/JCI95945
      PMID: 30153110
    • Presentation
      Anesthetic Management of the Obese Patient
      Frangakis S. 2018 Apr;
    • Presentation
      Evidence for Anesthesia-Induced Epigenetic Changes in Pediatric Patients
      Frangakis S. 2018 Apr;
    Featured News & Stories
    Department News
    Stephan Frangakis, M.D., Ph.D., receives NIH K08 grant to study potential genetic predictors of chronic postsurgical pain
    The project will be the largest postsurgical pain genetics study to date.