Areas of Interest
I am currently studying the biochemical features of the Cas9 protein from human pathogen Neisseria Meningitidis. The CRISPR-Cas systems are widespread in bacteria as an adaptive immune system for defense against bacteriophages or plasmids. In recent years, CRISPR-Cas9 has become a household name due to its adoption for eukaryotic DNA genome-editing and holds great promise for correcting genetic diseases. I am interested in exploring the programmable RNA-targeting potential of Cas9 proteins, a novel feature beyond their canonical roles as RNA-guided DNA-targeting CRISPR effectors.
Mentor: Yan Zhang, Ph.D.