Daniel Goldman, Ph.D.

Interim Chair, Department of Biological Chemistry
Bernard W Agranoff Collegiate Professor, Neuroscience
Professor, Biological Chemistry
Research Professor, Molecular and Behavioral Neuroscience Institute

 5045 BSRB, Box 2200

 

(734) 936-2057

Appointments

Biological Chemistry, Medical School
Molecular & Behavioral Neuroscience Institute

Areas of Interest

Retina regeneration • Optic nerve regeneration • Neuromuscular regeneration • Activity-dependent control of muscle gene expression

 
Blinding eye diseases like macular degeneration and glaucoma are among the top 10 disabilities affecting people. A major goal of neuroscientists is to identify strategies for restoring lost sight to those suffering from blindness. One approach is to use endogenous repair pathways to regenerate damaged retinal tissue. Unlike mammals, fish are able to regenerate an injured retina and this regeneration leads to restoration of lost sight. Our lab has discovered that Müller glia residing in the zebrafish retina respond to retinal injury and disease by dedifferentiating into a multipotent retinal stem cell that is able to regenerate all retinal cell types. Our research focuses on unraveling the cellular, molecular and biochemical mechanisms that drive and allow Müller glia reprogramming in the injured zebrafish retina. This information then informs us on strategies for stimulating Müller glia dedifferentiation and retina regeneration in mammals.

Muscular dystrophies are a group of diseases that are characterized by progressive muscle weakness and degeneration of skeletal muscle. These diseases are often associated with muscle atrophy and inefficient neuromuscular communication. Similarly, motor neuron diseases like ALS result in abrogation of neuromuscular communication leading to muscle atrophy and weakness. Our lab is interested in identifying interventions that will help restore neuromuscular communication and muscle function in people afflicted with muscular dystrophies and motor neuron diseases. We aim to identify signaling mechanisms by which muscle activity controls the expression of genes that regulate neuromuscular junction regeneration and muscle function in adult animals. It is our hope that this information may suggest novel strategies for restoring neuromuscular communication and muscle function in those suffering from muscular dystrophies and motor neuron diseases. Similar to our studies of retina regeneration, we rely on the tools of cell biology, molecular biology and biochemistry to unravel the mechanisms underlying neuromuscular communication and regeneration.

Honors & Awards

1994    University of Michigan Scientist Award
1995    Mental Health Research Institute Discovery Award
2001    Wilson Scholar, Wilson Medical Research Foundation
2003    University of Michigan Research Scientist Achievement Award
2010    Undergrad Research Opp Program Recognition Award for Outstanding Research Mentorship
2013    Research to Prevent Blindness Innovative Ophthalmic Research Award
2014    Bernard W. Agranoff Collegiate Professor of Neuroscience, University of Michigan
2014    AAAS Fellow, American Association for the Advancement of Science

 

Published Articles or Reviews

 
 
Wan J, Goldman D.
Curr Opin Genet Dev. 2016; 40:41-47.
 
Zhang S, Mu Z, He C, Zhou M, Liu D, Zhao XF, Goldman D, Xu H.
Invest Ophthalmol Vis Sci. 2016; 57:1991-2000.
 
Powell C, Cornblath E, Elsaeidi F, Wan J, Goldman D.
Sci Rep. 2016; 6:24851. 
 
Dach2-Hdac9 signaling regulates reinnervation of muscle endplates.
Macpherson PC, Farshi P, Goldman D.
Development 2015; 142: 4038-48.
 
Zhao, X-F., Wan, J., Powell, C., Ramachandran, R., Myers Jr., M.G., Goldman, D.
Cell Reports 2014; 9:272-284.
 
Jin Wan, J., Zhao, X-F., Vojtek, J. and Goldman, D.
Cell Reports 2014; 9:285-297.
 
Powell, C., Cornblath, E. and Goldman, D.
J Biol Chem 2014; 289:28924-28941.
 
Skaggs, K., Goldman, D. and Parent, J.M.
Glia 2014; 62:2061-2079.
 
Goldman, D.
Development 2014; 141:2745-2749.
 
Goldman, D.
Nat Rev Neurosci 2014; 15:431-442.
 
Tang, H., Inoki, K., Lee, M., Wright, E., Khuon, A., Khuon, A., Sugiarto, S., Garner, M., Paik, J., Depinho, R.,Goldman, D., Guan, K-L., and Shrager, J.B.
Science Signaling 2014; 7:ra18.
 
Elsaeidi. F., Bemben, M.A., Zhao X-F. and Goldman D.
J Neurosci 2014; 34:2632-2644.
 
Powell, C., Grant, A. R., Cornblath, E. and Goldman, D.
Proc Natl Acad Sci USA 2013; 110:19814-19819.
 
Ramachandran, R., Zhao, X-F. and Goldman, D.
Nature Cell Biology 2012; 14:1013-1023.
 
Wan, J., Ramachandran, R. and Goldman, D. 
Dev Cell 2012; 22:334-347.
 
Powell, C., Elsaeidi, F. and Goldman, D.
J Neurosci 2012; 32:1096-1109. 
 
Ramachandran, R., Zhao, X-F. and Goldman, D.
Proc. Natl. Acad. Sci. USA 2011; 108:15858-15863.
 
Ghiasvand, N., Rudolph, D., Mashayekhi, M., Brzezinski, J., Goldman, D. and Glaser, T.
Nature Neurosci 2011; 14:578-586.
 
Macpherson, P. C. D., Wang, X. and Goldman, D.
J. Cell. Biochem. 2011; 112:2149-2159.
 
Ramachandran R, Fausett BV, Goldman D.
Nature Cell Biol, 2010; 12:1101-1107.
 
Ramachandran R, Reifler A, Parent J, Goldman D.
J Comp Neurol, 2010; 518:4196-4212.
 
Veldman MB, Bemben MA, Goldman D.
Mol Cell Neurosci. 2010; 43:370-383.
 
Tang H, Macpherson P, Marvin M, Meadows E, Klein WH, Yang XJ, Goldman D.
Mol Biol Cell, 2009; 20:1120-1131.
 
Fausett BV, Gumerson JD, Goldman D.
J Neurosci, 2008; 28:1109-1117.
 
Veldman MB, Bemben MA, Thompson RC, Goldman D.
Dev Biol, 2007; 312:596-612.
 
Tang H, Goldman D.
Proc Natl Acad Sci U S A, 2006; 103:16977-16982.
 
Gulati-Leekha A, Goldman D.
Dev Biol, 2006; 296:29-47.
 
Fausett BV, Goldman D.
J Neurosci, 2006; 26:6303-6313.
 

For a complete list of this person’s PubMed publications, click HERE

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