Daniel Goldman, Ph.D.

Bernard W. Agranoff Collegiate Professor of Neuroscience
Professor, Biological Chemistry
Research Professor, Molecular & Behavioral Neuroscience Institute

Ofc: 5045 BSRB

109 Zina Pitcher Place

Ann Arbor, MI 48109-2200

 

(734) 936-2057

Areas of Interest

Sight is our most precious sense. Diseases of the retina, like macular degeneration and glaucoma cause blindness and are among the top 10 disabilities affecting people.  Macular degeneration results in death of photoreceptors, while glaucoma results in optic nerve degeneration and death of retinal ganglion cells. Although there are a number of approaches to restoring sight to people suffering from these diseases, we think a regenerative approach would be best. Unfortunately, mammals do not normally regenerate retinal neurons or optic axons. However, hope comes from the observation that teleost fish, like zebrafish, have remarkable regenerative abilities and can regenerate a damaged retina and optic nerve. Because the zebrafish and mammalian retina share structure and function, we suspect that mechanisms driving retina and optic nerve regeneration in zebrafish will suggest regenerative strategies that can be applied to mammals.

In the retina of fish and mammals there is only one major glial cell type referred to as a Müller glia. Müller glial cells are traditionally thought to participate in retina structure and homeostasis. We found that in zebrafish, Müller glia respond to retinal injury by undergoing a reprogramming event that endows them with properties of a retinal stem cell. These reprogrammed Müller glia divide to produce a progenitor that amplifies and is capable of regenerating all major retinal neuron types. Using a variety of molecular, genetic, biochemical and cell biological approaches, we have identified and characterized many of the signaling pathways and gene expression programs that underlie Müller glial cell reprogramming and retina regeneration. Similar approaches have been used to study optic nerve regeneration. This information is being used to suggest strategies for stimulating retina and optic nerve regeneration in mammals.

Honors & Awards

2014    Bernard W. Agranoff Collegiate Professor of Neuroscience, University of Michigan
2014    AAAS Fellow, American Association for the Advancement of Science
2013    Innovative Ophthalmic Research Award, Research to Prevent Blindness
2010    Outstanding Research Mentor Award, Undergraduate Research Opportunity Program
2003    Research Scientist Recognition Award, University of Michigan
2001    Wilson Scholar, Wilson Medical Research Foundation
1995    Discovery Award, Mental Health Research Institute
1994    Research Scientist Award, University of Michigan

Published Articles or Reviews

Recent Publications

Notch Suppression Collaborates with Ascl1 and Lin28 to Unleash a Regenerative Response in Fish Retina, But Not in Mice.
Elsaeidi F, Macpherson P, Mills EA, Jui J, Flannery JG, Goldman D.
J Neurosci. 2018; 38: 2246-61.

Opposing Actions of Fgf8a on Notch Signaling Distinguish Two Müller Glial Cell Populations that Contribute to Retina Growth and Regeneration.
Wan J, Goldman D.
Cell Rep. 2017; 19: 849-62.

Retina regeneration in zebrafish.
Wan J, Goldman D.
Curr Opin Genet Dev. 2016; 40: 41-7.

Zebrafish Müller glia-derived progenitors are multipotent, exhibit proliferative biases and regenerate excess neurons.
Powell C, Cornblath E, Elsaeidi F, Wan J, Goldman D.
Sci Rep. 2016; 6: 24851.

Leptin and IL-6 family cytokines synergize to stimulate Müller glia reprogramming and retina regeneration.
Zhao XF, Wan J, Powell C, Ramachandran R, Myers MG Jr, Goldman D.
Cell Rep. 2014; 9: 272-84.

Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration.
Wan J, Zhao XF, Vojtek A, Goldman D.
Cell Rep. 2014; 9: 285-97.

Zinc-binding domain-dependent, deaminase-independent actions of apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 2 (Apobec2), mediate its effect on zebrafish retina regeneration.
Powell C, Cornblath E, Goldman D.
J Biol Chem. 2014; 289: 28924-41.

Müller glial cell reprogramming and retina regeneration.
Goldman D.
Nat Rev Neurosci. 2014; 15: 431-42.

For a list of publications from MyNCBI, click HERE

Web Sites