Erik Zuiderweg, Ph.D.

Professor Emeritus, Biological Chemistry


Professor Zuiderweg received his B.Sc. (1973) and M.Sc. (1975) degrees from the University of Amsterdam and his Ph.D. (1980) degree from the University of Nijmegen. He was a postdoctoral research fellow at the University of Groningen and ETH Zurich. Professor Zuiderweg joined a research team at Abbott Laboratories in Chicago to help establish nuclear magnetic resonance spectroscopy (NMR) as a tool in rational drug design. He joined the University of Michigan faculty as a professor in 1991 and retired from active faculty status in 2018.

At the University of Michigan, Professor Zuiderweg contributed to NMR methodology development. He focused on the structure, dynamics, and interactions of heat shock protein 70 (Hsp70) chaperones mainly using NMR. Hsp70s are major players in tumor survival and Alzheimer's disease; modulation of the Hsp70 function is increasingly proposed as a possible avenue for therapy in both diseases. Professor Zuiderweg was also passionate about studying (thermo) dynamics using NMR, contributing to the now (almost) universal understanding that protein molecular dynamics is essential to protein function. During his tenure at the University of Michigan, Professor Zuiderweg served as the acting director of the Biophysics Research Division and as the principal investigator of the University of Michigan node of the Michigan Center for Structural Biology. Professor Zuiderweg taught biochemistry at the undergraduate and graduate levels and served on departmental committees in biological chemistry and biophysics, as well as on national study sections. He was a pioneer in NMR technology and passed along his expertise to a number of faculty and students in order to continue the exploration of NMR. In his retirement Professor Zuiderweg has relocated to the Netherlands to assist a local university with NMR technology and to potentially create his own business in collaboration with former UM faculty to develop new uses for NMR technology.

Published Articles or Reviews

Recent Publications

The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein.
Taylor IR, Ahmad A, Wu T, Nordhues BA, Bhullar A, Gestwicki JE, Zuiderweg ERP.
J Biol Chem. 2018; 293: 10796–809.

High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex.
Taylor IR, Dunyak BM, Komiyama T, Shao H, Ran X, Assimon VA, Kalyanaraman C, Rauch JN, Jacobson MP, Zuiderweg ERP, Gestwicki JE.
J Biol Chem. 2018; 293: 4014–25.

X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.
Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE.
J Biol Chem. 2018; 293: 2370–80.

Anti-leukemia activity of a Hsp70 inhibitor and its hybrid molecules.
Park SH, Kim WJ, Li H, Seo W, Park SH, Kim H, Shin SC, Zuiderweg ERP, Kim EE, Sim T, Kim NK, Shin I.
Sci Rep. 2017; 7: 3537.

The remarkable multivalency of the Hsp70 chaperones.
Zuiderweg ER, Hightower LE, Gestwicki JE.
Cell Stress Chaperones. 2017; 22: 173–89.

Backbone and methyl resonance assignments of the 42 kDa human Hsc70 nucleotide binding domain in the ADP state.
Zuiderweg ER, Gestwicki JE.
Biomol NMR Assign. 2017; 11: 11–15.

For a list of publications from Pubmed, click HERE