Kaushik Ragunathan, Ph.D.

Assistant Professor, Biological Chemistry

Office: 3220D MSRB III
Lab: 3240 MSRB III
1150 W. Medical Center Drive
Ann Arbor, MI 48109-5606


(734) 763-0641

Areas of Interest

My lab is interested in the molecular mechanisms that define how the combinatorial logic of histone modifications and its dynamic interactions with histone binding proteins encodes stable and heritable patterns of gene expression. We take a multidisciplinary perspective that synthesizes genetics, biochemistry and biophysical approaches to capture cellular processes across different spatial and temporal regimes.  


Postdoctoral Fellow, Department of Cell Biology, Harvard Medical School
Ph.D, Biophysics and Computational Biology, University of Illinois, Urbana-Champaign
B.Tech, Biotechnology, PSG College of Technology, India

Published Articles or Reviews

The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.
Bao K, Shan CM, Chen X, Raiymbek G, Monroe JG, Fang Y, Toda T, Koutmou KS, Ragunathan K, Lu C, Berchowitz LE, Jia S.
PLoS Genet. 2022; 18: e1010049.

An H3K9 methylation dependent protein interaction regulates the non-enzymatic function of a putative histone demethylase.
Raiymbek G, An S, Khurana N, Gopinath S, Larkin A, Biswas S, Trievel RC, Cho US, Ragunathan K.
Elife. 2020; 9: e53155.

Evolution of protein-coupled RNA dynamics during hierarchical assembly of ribosomal complexes.
Abeysirigunawardena SC, Kim H, Lai J, Ragunathan K, Rappé MC, Luthey-Schulten Z, Ha T, Woodson SA.
Nat Commun. 2017; 8: 492.

Epigenetics. Epigenetic inheritance uncoupled from sequence-specific recruitment.
Ragunathan K, Jih G, Moazed D.
Science. 2015; 348: 1258699.

Cooperative conformational transitions keep RecA filament active during ATPase cycle.
Kim SH, Ragunathan K, Park J, Joo C, Kim D, Ha T.
J Am Chem Soc. 2014; 136: 14796–800.

Protein-guided RNA dynamics during early ribosome assembly.
Kim H, Abeysirigunawarden SC, Chen K, Mayerle M, Ragunathan K, Luthey-Schulten Z, Ha T, Woodson SA.
Nature. 2014; 506: 334–8.

ATP-independent diffusion of double-stranded RNA binding proteins.
Koh HR, Kidwell MA, Ragunathan K, Doudna JA, Myong S.
Proc Natl Acad Sci USA. 2013; 110: 151–6.

RecA filament sliding on DNA facilitates homology search.
Ragunathan K, Liu C, Ha T.
Elife. 2012; 1: e00067.

Real-time observation of strand exchange reaction with high spatiotemporal resolution.
Ragunathan K, Joo C, Ha T.
Structure. 2011; 19: 1064–73.

For a list of publications from Pubmed, click HERE

Web Sites