Areas of Interest
My lab is interested in the molecular mechanisms that define how the combinatorial logic of histone modifications and its dynamic interactions with histone binding proteins encodes stable and heritable patterns of gene expression. We take a multidisciplinary perspective that synthesizes genetics, biochemistry and biophysical approaches to capture cellular processes across different spatial and temporal regimes.
Postdoctoral fellow, Department of Cell Biology, Harvard Medical School
Ph.D, Biophysics and Computational Biology, University of Illinois, Urbana-Champaign
B.Tech, Biotechnology, PSG College of Technology, India
Ragunathan, K., G.Jih and D.Moazed “Epigenetic inheritance uncoupled from sequence specific recruitment” Science 348(6230), 1258699 (2015)
S.Kim , K. Ragunathan , J. Park , C. Joo , D. Kim , and T. Ha “Cooperative conformational transitions keep RecA filament active during ATPase cycle” J. Am. Chem. Soc., 136 (42), pp 14796–14800 (2014)
H. Kim, S.C. Abeysirigunawarden, K. Chen, M. Mayerle, K. Ragunathan, Z. Luthey-Schulten, T. Ha , S.A. Woodson, “Protein-guided RNA dynamics during early ribosome assembly”, Nature 506, 334–338 (2014)
News and Views: Kathleen B. Hall "Molecular biology: Protein binding cannot subdue a lively RNA"
Ragunathan,K., C. Liu and T.Ha, “RecA filament sliding on DNA facilitates homology search”, eLife 1:e00067 (2012)
Commentary - B.Gibb and E.Greene, "Sliding to the rescue of damaged DNA"
H.Koh, M.Kidwell, K. Ragunathan, J.Doudna and S.Myong “ATP-independent diffusion of double stranded RNA binding proteins”, Proc.Natl.Acad.Sci 110(1) 151-156 (2012)
Ragunathan,K., C. Joo and T.Ha, “Real time observation of strand exchange reaction with high spatiotemporal resolution”, Structure 19(8) 1064-73 (2011)
Commentary - C.Wyman, "Mechanistic insight from Chaos: How RecA Mediates DNA Strand Exchange" Evaluated at F1000 biology
Jain, A., R.Liu, B.Ramani, E.Aruaz, Y.Ishitsuka, K. Ragunathan, J. Park, J. Chen, Y. Xiang and T.Ha, “Probing cellular protein complexes using single-molecule pull-down”, Nature 473, 484-488 (2011)
Lee, J., S. Lee, K. Ragunathan, C. Joo, T. Ha and S. Hohng, “Single-molecule four-color FRET”, Angew. Chem. Int. Ed. 49(51), 9922-9925 (2010)
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