Areas of Interest
The heme regulatory motif (HRM) is a short sequence featured by a Cys-Pro core and usually surrounded by both a basic residue preceding the Cys and a hydrophobic residue following Pro. HRMs been found in diverse hemoproteins, serving as heme binding sites and mediating heme-dependent regulatory activities. Through those HRMs, heme partially regulates its own fate in different systems. My current work focuses on understanding functions of the heme-HRM interactions in heme oxygenase 2, which is an important enzyme for free heme degradation. It may add a linkage to the network of heme homeostasis maintenance.