Matthew Chapman, Ph.D.

Affiliate Faculty, Biological Chemistry
Professor, Molecular, Cellular, and Developmental Biology

5268 BSB
1105 N. University Avenue
Ann Arbor, MI 48109-1085


(734) 764-7592

Areas of Interest

Curli are extracellular organelles produced by Escherichia coli and certain Salmonella species. These fibers are structurally and biochemically identical to eukaryotic amyloid fibers, which underlie diverse mammalian ailments including Alzheimer’s disease (AD), systemic amyloidosis, bovine spongiform encephalopathy (mad cow disease), and Creutzfeldt-Jacob disease. The Chapman lab uses the curli system to study the fundamental principles of amyloid formation. We dissect the biogenesis of curli fibers, as well as the consequences of curli amyloid formation on the biology of microbial communities.

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