Areas of Interest
The Uhler laboratory studies the role of neuronal signaling in the context of human neurologic and psychiatric disorders. We have developed a number of tools to study gene expression in neurons derived from mouse and human stem cells. We derive various neuronal populations using expression of neurogenic transcription factors to produce excitatory and inhibitory neurons. Using these neurons, we have defined signal transduction cascades for fibroblast growth factors (FGFs) and identified genes regulated by FGFs that alter neuronal function. We are currently deriving neuronal populations from patients with major depressive disorder (MDD) to determine if FGF signaling is altered in MDD. We are also generating neuronal populations to understand the role of the Tau protein in Alzheimer's disease.
The work in our laboratory is inherently multidisciplinary in nature and employs biochemical, molecular genetic, cell biological, and electrophysiological techniques. These studies often involve collaborations with other laboratories at Michigan or at other institutions.
Honors & Awards
Endowment for Basic Sciences Teaching Award, University of Michigan Medical School, 2013, 2014
Outstanding Faculty Service Award, University of Michigan Neuroscience Program, 2004
Research Scientist Recognition Award, University of Michigan, 1999
Faculty Recognition Award, University of Michigan, 1992
Basil O'Connor Research Scholar Award, March of Dimes, 1986–1988
Fibroblast growth factor 2 regulates activity and gene expression of human post-mitotic excitatory neurons.
Gupta S, M-Redmond T, Meng F, Tidball A, Akil H, Watson S, Parent JM, Uhler M.
J Neurochem. 2018; 145: 188-203.
Rapid Generation of Human Genetic Loss-of-Function iPSC Lines by Simultaneous Reprogramming and Gene Editing.
Tidball AM, Dang LT, Glenn TW, Kilbane EG, Klarr DJ, Margolis JL, Uhler MD, Parent JM.
Stem Cell Reports. 2017; 9: 725-731
HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.
Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K, Chen Z, Uhler MD, Rui L, Gonzalez FJ, Shah YM.
Cell Metab. 2016; 23: 505-16.
Transcriptional regulatory events initiated by Ascl1 and Neurog2 during neuronal differentiation of P19 embryonic carcinoma cells.
Huang HS, Redmond TM, Kubish GM, Gupta S, Thompson RC, Turner DL, Uhler MD.
J Mol Neurosci. 2015; 55: 684-705.
Protein kinase A modulates transforming growth factor-β signaling through a direct interaction with Smad4 protein.
Yang H, Li G, Wu JJ, Wang L, Uhler M, Simeone DM.
J Biol Chem. 2013; 288: 8737-49.
Negative regulation of Yap during neuronal differentiation.
Zhang H, Deo M, Thompson RC, Uhler MD, Turner DL.
Dev Biol. 2012; 361: 103-15.
Ascl1-induced neuronal differentiation of P19 cells requires expression of a specific inhibitor protein of cyclic AMP-dependent protein kinase.
Huang HS, Turner DL, Thompson RC, Uhler MD.
J Neurochem. 2012; 120: 667-83.
For a list of publications from Pubmed, click HERE