Michael Wolfe

Ph.D. Student
Mentor: Dr. Peter Freddolino


Freddolino Lab

3328, MSRB 3, Box 5606


Areas of Interest

My primary research interests are in the global regulation of gene expression, particularly at the post-transcriptional level. More specifically, I am interested in determining global RNA-protein and RNA-RNA interactions within Escherichia coli under different stress conditions and developing mathematical models to explain changes in the interaction patterns seen. I hope to accomplish this through the combination of novel RNA-complex purification methods developed in the Freddolino lab, the use of modern high throughput sequencing, and subsequent bioinformatic analysis. Applications of this research include: better understanding of the regulatory logic that underlies complex biological systems, a deeper understanding of the factors involved in the development of bacterial antibiotic resistance, and the ultimate goal of developing a working model of a living organism from the molecular to systems-level scale.


Undergraduate Honors Thesis Defense


"Investigation of non-canonical enzyme activities associated with metabolism of tRNAHis in eukaryotes"

Undergraduate Honors Thesis Defense

Advisor: Dr. Jane Jackman

Committee: Dr. Keith Gooch, Dr. Venkat Gopalan Columbus, OH

March 31, 2014

Honors & Awards




National Science Foundation Graduate Research Fellow

Ann Arbor, MI

April 2015 - Present


Detroit Zoo Fellowship in Science Communication

Royal Oaks, MI

October 2014- Present


Bernard L. Maas Endowed Medical Fellowship Awardee

Ann Arbor, MI

September 2014- Present


National Science Foundation Graduate Research Fellowship Honorable Mention

Columbus, OH

March 2014- April 2015


Arnold and Mabel Beckman Foundation Scholar

Columbus, OH

March 2011- August 2012


Published Articles or Reviews