December 5, 2019

Uhn-Soo Cho and Yali Dou are the corresponding authors of an article in Nature Communications

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

In an impressive example of collaboration within the Biological Chemistry Department, members of the Cho lab, the Dou lab, the Cianfrocco lab, and the Zhang lab report the single-particle cryo-electron microscopy (cryo-EM) structure of the human MLL1 core complex bound to the nucleosome. Their study sheds light on how the MLL1 complex engages chromatin and how chromatin binding promotes the tri-methylation activity of MLL1.

Read the Nature Communications article HERE.