January 9, 2020

Adam Thelen of the O'Brien lab publishes a paper in the Journal of Biological Chemistry

Recognition of 1,N2-ethenoguanine by alkyladenine DNA glycosylase is restricted by a conserved active site residue.

Results from the O'Brien lab suggest that 1,N2-ethenoguanine (εG) is not a primary substrate of alkyladenine DNA glycosylase (AAG) and that current models for repair of harmful etheno lesions in humans should be revised.

Read the JBC paper HERE.