Results from the O'Brien lab suggest that 1,N 2-ethenoguanine (εG) is not a primary substrate of alkyladenine DNA glycosylase (AAG) and that current models for repair of harmful etheno lesions in humans should be revised.
Read the JBC paper HERE.
Recognition of 1,N2-ethenoguanine by alkyladenine DNA glycosylase is restricted by a conserved active site residue.
Results from the O'Brien lab suggest that 1,N 2-ethenoguanine (εG) is not a primary substrate of alkyladenine DNA glycosylase (AAG) and that current models for repair of harmful etheno lesions in humans should be revised.
Read the JBC paper HERE.