August 25, 2022

The Kerppola lab publishes a research article in Immunology

Keap1 moderates the transcription of virus induced genes through G9a-GLP and NFκB p50 recruitment

Excess and maladaptive immune responses to virus infections are a major contributing factor to the morbidity and mortality of COVID-19 and other diseases. Conversely, inadequate immune responses to vaccines and pathogens by individuals with suppressed immune function expose them to infections. In an article published in Immunology, Dr. Veronica Burns and Dr. Tom Kerppola characterize molecular mechanisms that moderate the transcription of genes that are induced by virus infection. Characterization of the mechanisms whereby Keap1, G9a-GLP and NFκB p50 moderate virus induced gene transcription identifies new targets for therapeutic agents that can modulate immune responsiveness.

Research article in Immunology