Historical Alumni List

From the appointment in the early 1900's of Victor C. Vaughan as the first Professor of Biochemistry to our current roster of faculty, students and postdoctoral fellows, the BioChem family is a large and distinguished group. We are knit together by our friendships, sense of shared community and history, and a common passion for the discovery of new knowledge at the frontiers of biological chemistry.

On these pages, alumni and friends of the department, essential and valued members of the BioChem family, will find information and resources that will help them stay connected with the department and contribute to its ongoing vitality. We would love to hear your latest news and keep you up to date on the latest happenings in the department. Send us your contact information, give us an update on your personal and professional accomplishments, get on our newsletter mailing list, join one of our regional networks for meetings or agree to serve as a mentor/contact for new BioChem graduates at the Registration/Updates page.

Click here to access the Alumni Registration Form.

Take a look back over the years at our BioChem Alumni:

1920s

1930s

Joseph P. Chandler, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1930

The Intermediary Metabolism of Phenylalanine

Howard D. Lightbody, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1930

The relation of the protein and cystine content of the diet to the growth and chemical composition of the hair, and changes in the chemical composition of hair caused by extraction with water

Abraham White, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1931

The effect of the oral administration of bromobenzene to the dog on the partition of urinar sulfur

Mabel Marie Miller, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1932

The utilization of xylose by the white rat

Robert L Grant, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1933

The preparation and properties of some products of the partial hydrolysis of the fibroin of silk

S. Allan Lough, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1933

The oxidation of cystine and some related sulfur compounds in vitro

Alfred K. Silberman, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1933

The metabolism of rhamnose a natural occurring methyl pentose

Victor Julius Tulane, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1933

Hippuric acid synthesis in hydrazine poisoning

Robert Wallace Virtue, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1933

Comparative studies on the metabolism of 1-cystine and d1-methionine in the organism of the rabbit

William C. Lee, PhD.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1934

A study of the influence of the state of nutrition upon the composition of the tissues and protein of the white rat

Adelaida M. Bendana (Brown), Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1935

The Utilization of Insulin by the White Rat

Norbert Harper Fell, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1935

Chemical and immunological properties of the proteins of silk

Florence Roy White, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1935

The metabolism of some peptides containing cystine or derivatives of cystine

Lila Miller, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1936

Enzymatic decomposition on native protein

Evangeline T. Papageorge, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1936

Studies in the intermediary metabolism of phehylalanine

Svend Pederson, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1936

A comparative study of the metabolism of glutamic acid, pyrrolidone carboxylic acid, proline, and hydroxyproline in the rabbit

Barker Hastings Brown, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1937

Studies of the Intermediary Metabolism of the Sulfur-Containing Amino Acids of the Protein Molecule

Ross Aiken Gortner, Jr., Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1938

A study of the factors which influence the toxicity of selenium compounds

Evelyn V. Heard, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1937

The relation of dietary methionine to the growth and the chemical composition of the hair of the white rat

Joseph Isaac Routh, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1937

Chemical studies of the keratin of wool and its reduction products, the kerateines

Lawrence Louis, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1937

The composition of tissue proteins as influenced by the hepatic poisons, hydrazine and phosphorus

Walter David Block, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1938

A Comparative Study of Factors Which Influence the Chemical Composition of Some Keratins

Pong Cheh Jen, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1938

The metabolism of some derivatives of cystine.

Gertrude Rodney, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1938

The oxidative deamination of some isomeric aminopropionic acids

Sidney F. Velick, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1938

A study of the precursors of taurocholic acid

Carleton R. Treadwell, Ph.D.

Mentor: Henry C. Eckstein, Ph.D.

Thesis Defense: 1939

A study of the effect of high and low fat diets on the cholesterol metabolism of four generations of white rats

Bruno Vassel, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1939

A comparative study of the effects of glucose, sucrose, fructose and invert sugar on growth, fat and glycogen formation in the white rat

Julius Schultz, Ph.D.

Mentor: Howard B. Lewis, Ph.D.

Thesis Defense: 1939

A study of the factors influencing the detoxification of selenium in the animal body

1940s

1950s

1960s

Alice del Campillo-Campbell, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1960

An Enzymatic Study of the Carboxylation Reaction in Leucine Metabolism

Walter B. Dempsey, Ph.D.

Mentor: Halvor Christensen, Ph.D.

Thesis Defense: 1960

The Formation of a Stable Complex Between Pyridoxal 5’-Phosphate and Bovine Serum Albumin

Sondra Schlesinger, Ph.D.

Mentor: G. Robert Greenberg, Ph.D.

Thesis Defense: 1960

Formation of deoxycytidylate hydroxymethylase and phage by disrupted T2 bacteriophage

George Watha Kosicki, Ph.D.

Mentor: Paul Srere, Ph.D.

Thesis Defense: 1961

Studies on the citrate condensing enzyme

Ronald L. Somerville, Ph.D.

Mentor: G. Robert Greenberg, Ph.D.

Thesis Defense: 1961

Nucleotide metabolism in Escherichia coli infected with bacteriophage T2

Dexter Daniel Fossitt, Ph.D.

Mentor: Isadore Bernstein, Ph.D.

Thesis Defense: 1962

Biosynthesis of ribose and deoxyribose in Pseudomonas saccharophila

Naba Kumar Gupta, Ph.D.

Mentor: William Robinson, Ph.D.

Thesis Defense: 1962

Enzymatic reactions related to the metabolism of lactalydehyde and urocanic acid

LaVerne Gene Schirch, Ph.D.

Mentor: Merle Mason, Ph.D.

Thesis Defense: 1962

A study of serine transhydroxymethylase

Huber Richard Warner, Ph.D.

Mentor: William E. M. Lands, Ph.D.

Thesis Defense: 1962

The structure and metabolism of plasmalogen

Amar Nath Bhaduri, Ph.D.

Mentor: Paul Srere, Ph.D.

Thesis Defense: 1963

Studies of the Stimulation of Fatty Acid Biosynthesis by Citrate and by Mitochondria

James Edward Christner, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1963

Role of Biotinyl Adenylate in the enzymatic activation of Biotin

Helen Jean Gigliotti, Ph.D.

Mentor: Bruce Levenberg, Ph.D.

Thesis Defense: 1963

Studies on the g-glutamyltranserase and arylhydrazine oxidase activities of Agaricus Bisporus

Umadas Maitra, Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: 1963

Enzymatic reactions in the mammalian metabolism of g-hydroxyglutamate

Nancy Goldman Nossal, Ph.D.

Mentor: G. Robert Greenberg, Ph.D.

Thesis Defense: 1963

Deoxyribonucleases of Escherichia coli infected with T2 Bacteriophage

Fritz M. Rottman, Ph.D.

Mentor: Armand J. Guarino, Ph.D.

Thesis Defense: 1963

The mode of action of cordycepin in the inhibition of Bacillus subtilis growth

Lewis Dale Stegink, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1963

Purification and properties of the b-hydroxy-b-methylglutaryl coenzymes a cleavage enzyme from beef liver

Jack Distler, Jr., Ph.D.

Mentor: Karl F. Guthe, Ph.D.

Thesis Defense: 1964

The biosynthesis of heteropolysaccarides by Streptococcus pyogenes and Type XIV Diplococcus pneumonia

Margaret I. S. Lomax, Ph.D.

Mentor: G. Robert Greenberg, Ph.D.

Thesis Defense: 1964

Thymidylate synthetase of Escherichia coli

Robert B. Sanders, Ph.D.

Mentor: Thomas R. Riggs, Ph.D.

Thesis Defense: 1964

The effect of insulin on 1-aminocyclopentanecarboxylic acid distribution in the rat

Charles G. Winter, Ph.D.

Mentor: Halvor Christensen, Ph.D.

Thesis Defense: 1964

The transport of neutral amino acids by erythrocytes and reticulocytes

John Kenneth Hoober, Ph.D.

Mentor: Isadore Bernstein, Ph.D.

Thesis Defense: 1965

The Differential Incorporation of Amino Acids (In Vivo) into Proteins of the Newborn Rat Epidermis

Rosalind S. Labow, Ph.D.

Mentor: William Robinson, Ph.D.

Thesis Defense: 1965

Crystalline D-serine dehydrase from Escherichia coli

Richard R. Swain, Ph.D.

Mentors: Eugene E Dekker, Ph.D.; Merle Mason, Ph.D.

Thesis Defense: 1965

Studies on the origin and function of the cotyledonary amylase of Pisum sativum

Subhash C. Basu, Ph.D.

Mentor: Saul Roseman, Ph.D.

Thesis Defense: 1966

Studies on the Biosynthesis of Gangliosides

Jeanette R. W. Piperno, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: 1966

Neutral Amino Acid Transport Studies in Escherichia coli; Isolation of a Possiple Receptor Site for Leucine Transport

Allen Charles Stoolmiller, Ph.D.

Mentor: Robert H. Abeles, Ph.D.

Thesis Defense: 1966

The mechanism of L-2-keto-3-deoxyarabonate dehydratase in Pseudomonas Saccharophila

Gene Larry Cottam, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1967

Catalytic Mechanism and Subunit Structure of Pyruvate Kinase

Eloise Eavenson, Ph.D.

Mentor: Halvor Christensen, Ph.D.

Thesis Defense: 1967

Amino Acid Transport Systems in the Pigeon Erythrocyte

John Stewart Ellingson, Ph.D.

Mentor: William E. M. Lands, Ph.D.

Thesis Defense: 1967

Phospholipid Reactivation of Plasmalogen Metabolism

Chava T. S. Hardesty, Ph.D.

Mentor: Saul Roseman, Ph.D.

Thesis Defense: 1967

The chemical and enzymatic synthesis of N-acetyl-D-mannosamine

Rodger Dale Kobes, Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: 1967

Catalytic properties and mechanism of action of beef liver 2-keto-4-hydroxyglutarate aldolase

Joyce Ann Livak Benjamins, Ph.D.

Mentor: Bernard Agranoff, Ph.D.

Thesis Defense: 1967

Studies on the biosynthesis of phosphatidyl inositol

Julian (Bill) Peterson, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1967

Rubredoxin: Chemical Properties and Role as an Electron Carrier in Omega-Oxidation

Sanford (Sandy) Singer, Ph.D.

Mentor: Merle Mason, Ph.D.

Thesis Defense: 1967

Studies of a possible role on anionic steroid derivatives in enzyme induction

Linda L. Slakey, Ph.D.

Mentor: William E. M. Lands, Ph.D.

Thesis Defense: 1967

The composition of rat liver triglycerides

Chava Telem Spivak, Ph.D.

Mentor: Saul Roseman, Ph.D.

Thesis Defense: 1967

The chemical and enzymatic synthesis of N-acetyl-D-mannosamine

Byron Eugene Anderson, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: 1968

Studies on the Phosphoenolpyruvate Dependent Phosphotransferase system of Escherichia coli

Beverly Ann Dale-Crunk, Ph.D.

Mentor: G. Robert Greenberg, Ph.D.

Thesis Defense: 1968

Control of Thymine Utilization By Escherichia coli

Hsien-wen Feng, Ph.D.

Mentor: Thomas R. Riggs, Ph.D.

Thesis Defense: 1968

The effect of sulfhydryl agents on amino acid uptake by normal and estrogen-primed immature rat uteri

Jonathan B. Ford, Ph.D.

Mentor: Merle Mason, Ph.D.

Thesis Defense: 1968

The effects of steroid and non-steroid metabolites on the catalytic activity, conformation, and stability of phosphorylase b

Thelma Marie Lauderbaugh, Ph.D.

Mentor: William E. M. Lands, Ph.D.

Thesis Defense: 1968

The metabolsim of 1,2-diacylglycero-3-phosphorylethanolamine

Richard H. Matthews, Ph.D.

Mentor: J. Lawrence Oncley, Ph.D.

Thesis Defense: 1968

Free diffusion: Representation of the concentration gradient by means of a gram-charlier series, and the diffusion coefficient of insulin

Dan William Reed, Ph.D.

Mentor: Donald Hultquist, Ph.D.

Thesis Defense: 1968

Studies on chromoproteins of human erythrocytes

Stanford Trent Roodman, Ph.D.

Mentor: G. Robert Greenberg,

Thesis Defense: 1968

A temperature-sensitive mutant of Escherichia coli which produces thymidylate synthetase at non-permissive temperatures

Gordon S. Hassing, Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: 1969

Studies concerned with the structure and activity of concanavalin A

Jerrold J. Heindel, Ph.D.

Mentor: Thomas R. Riggs, Ph.D.

Thesis Defense: 1969

Growth hormone stimulation of amino acid transport in tissues of the vitamin B6 deficient rat

Paul F. Hollenberg, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1969

Studies on the subunit structure and catalytic site of pyruvate kinase

Roger Scott Lane, Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: 1969

Studies on the chemical and enzymatic properties of 2-keto-4-hydroxyglutarate aldolase from bovine liver

Rowena G. Matthews, Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: 1969

Free and Complexed Forms of Old Yellow Protein: Their Physical and Catalytic Properties

William Roy Penrose, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: 1969

Purification and properties of a leucine-binding protein from Escherichia coli

David H. Petering, Ph.D.

Mentor: Graham Palmer, Ph.D.

Thesis Defense: 1969

Aspects of the iron-sulfur chemistry of spinach ferredoxin

Robert Jack Roon, Ph.D.

Mentor: Bruce Levenberg, Ph.D.

Thesis Defense: 1969

Studies on urea amidolyase, a new biotin-enzyme of urea metabolism

1970s

Carl Julius Belke, Ph.D.

Mentor: Jules Shafer, Ph.D.

Thesis Defense: 1970

Cyclization of some 2-hydroxymethylbenzamides: A Model for the Acylation of a-chymotrypsin

Bruce Daniel Burleigh Jr., Ph.D.

Mentor: Charles Williams, Ph.D.

Thesis Defense: 1970

Structural Studies on Escherichia coli Lipoamide Dehydrogenase

Ross Sheldon Feldberg, Ph.D.

Mentor: Prasanta Datta, Ph.D.

Thesis Defense: 1970

The Purification and Properties of L-Threonine Deaminase From Rhodospirillum rubrum

Eglis Teodors Lode, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1970

Studies on the structure and function of rubredoxin

Philip George Passon, Ph.D.

Mentor: Donald Hultquist, Ph.D.

Thesis Defense: 1970

Studies on pink copper-protein, cytochrome b5, and cytochrome b5 reductase from human erythrocytes

Marilyn Schuman (Jorns), Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: 1970

Glycolic acid oxidase: Spectral and catalytic properties

Edwin Lee Thomas, Ph.D.

Mentor: Halvor Christensen, Ph.D.

Thesis Defense: 1970

Interactions between the co-substrates of a Na+-dependent neutral amino acid transport system

Gene Floyd Tutwiler, Ph.D.

Mentor: Lawrence H. Louis, Ph.D.

Thesis Defense: 1970

Physiological and biological characterization of a diabetogenic peptide from bovine adenohypophysis

David Penfield Ballou, Ph.D.

Mentor: Graham Palmer, Ph.D.

Thesis Defense: 1971

Instrumentation for the Study of Rapid Biological Oxidation-Reduction Reactions by EPR and Optical Spectroscopy

Alan Erwin Brandt, Ph.D.

Mentor: George Jourdian, Ph.D.

Thesis Defense: 1971

Studies on the Biosynthesis of Chondroitin Sulfate

Michael Flashner, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1971

Role of sulfhydryl groups in the mechanism of action of pyruvate kinase

William Galbraith, Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: 1971

Studies on the hemagglutinin of the lima bean

Barbara Ann Hansen, Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: 1971

Bovine liver 2-keto-4-hydroxyglutarate aldolase: Cyanide inactivation and photooxidation studies

Carolyn M. Myers, Ph.D.

Mentor: Margaret J. Hunter, Ph.D.

Thesis Defense: 1971

Isolation and characterization of an extracellular high molecular weight protein-lipopolysaccharide-lipid complex of Escherichia coli B

William Lee Smith, Ph.D.

Mentor: William E. M. Lands, Ph.D.

Thesis Defense: 1971

Oxygenation of polyunsaturated fatty acids by sheep vesicular gland and soybean dioxygenases

Howard S. Tager, Ph.D.

Mentor: Halvor Christensen, Ph.D.

Thesis Defense: 1971

2-aminoorbornane-2-carboxylic acid: physical, chemical and biochemical properties of the four isomers

Tetsufumi Ueda, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1971

Purification and characterization of rubredoxin-DPN reductase, and electron carrier in w-hydroxylation

Robert David Anderson, Ph.D.

Mentor: Martha Ludwig, Ph.D.

Thesis Defense: 1972

The Structure of a Clostridal Flavodoxin, and Electron Transferring Flavoprotein, in the Semiquinone State: Interpretation of an Electron Density Map at 3.25 Å Resolution

Peter Alexander Apgar, Ph.D.

Mentor: Martha Ludwig, Ph.D.

Thesis Defense: 1972

2-EXO-Aminobornane-2-Carboxylic Acid HBR: Crystal and Molecular Structure of the (1R, 2R, 4S) Isomer Clostridium MP Flavodoxin: Comparison of Oxidized and Semiquinone Forms at 3.25 Å resolution

Stephen M. Dungan, Ph.D.

Mentor: Prasanta Datta, Ph.D.

Thesis Defense: 1972

Purification, Properties, and Allosteric Regulation of Aspartokinase From Pseudomonas Fluorescens

Richard S. Foemmel, Ph.D.

Mentor: Isadore Bernstein, Ph.D.

Thesis Defense: 1972

Localization of Fructose 1, 6-diphosphate aldolase in the endoplasmic reticulum of the rat hepatocyte: Biochemical and cytochemical studies

Theodore R. Oegema, Jr., Ph.D.

Mentor: George W. Jourdian, Ph.D.

Thesis Defense: 1972

Studies on the physical, chemical and biological properties of ovumucoid

William Stern, Ph.D.

Mentor: Paul Weinhold, Ph.D.

Thesis Defense: 1972

Regulation of choline phosphoglyceride synthesis in developing lungs

Betty Kenyon Blossey, Ph.D.

Mentor: Jules Shafer, Ph.D.

Thesis Defense: 1973

Inactivation of Alpha-chymotrypsin at the Active Site by a Water Soluble Carbodiimide

Robert Lee Campbell, Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: 1973

D-1-Amino-2-Propanol:NAD Oxidoreductase From Escherichia coli K-12 -- Purification, Properties, and Role in L-Threonine Metabolism

Linda F. Thompson Dunham, Ph.D.

Mentor: Alan Price, Ph.D.

Thesis Defense: 1973

Properties and Role of the dTTP/duTP Nucleotidohydrolase Induced After øe Infection of Bacillus subtilis

Douglas Allan Feldman, Ph.D.

Mentor: Prasanta Datta, Ph.D.

Thesis Defense: 1973

Catabolite activation of the Biodegradative Threonine Dehydratase From Escherichia coli

Marcia I. Steinberg Flashner (Steinberg), Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: 1973

Studies on the flavoprotein L-lysine monooxygenases

Sharon Ruth Grady (Marks), Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: 1973

Tritium exchange, protein modification, and kinetic studies with 2-keto-4-hydroxyglutarate aldolase

Lester Irving Harrison, Ph.D.

Mentor: Halvor Christensen, Ph.D.

Thesis Defense: 1973

Effect of hormones and solute exchange on the transport of model amino acids

Colleen E. Hayes, Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: 1973

Isolation and characterization of an a-D-Galactosyl Binding Lectin from the seeds of Bandeiraea simplicifolia

Robert Aldon Mathews, Ph.D.

Mentor: Graham Palmer, Ph.D.

Thesis Defense: 1973

Chemical and physical studies of a bacterial ferredoxin

Edward T. Maggio, Ph.D.

Mentor: Jules Shafer, Ph.D.

Thesis Defense: 1973

Aminoethylpapain: Properties and reactivity of papain aminoethylated at the active site

Frank Masiarz, Ph.D.

Mentor: Bernard Agranoff, Ph.D.

Thesis Defense: 1973

Acyl-coenzyme A: a acyltransferase a novel mammalian enzyme

James C. Robbins, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: 1973

Alanine, glycine, and serine transport by Escherichia coli K12

Niels Daniel Schonbeck, Ph.D.

Mentor: Jules Shafer, Ph.D.

Thesis Defense: 1973

Covalent and non-covalent interactions between apoenzyme and pyridoxal 5’-phosphate in D-serine dehydratase from Escherichia coli

Sidney Strickland, Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: 1973

Studies on melilotate hydroxylase and a model hydroxylating system

Aaron Shepard Abramovitz, Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: 1974

Interactions of old yellow enzyme with aromatic compounds

Jodie Lee Duke, Jr., Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: 1974

Structural Studies of Pneumococcal Type XII Capsular Polysaccharide; Synthesis and Immunochemistry of Two Kojibiosyl-Protein Conjugates

Eric Theodore Jones, Ph.D.

Mentor: Charles Williams, Ph.D.

Thesis Defense: 1974

Disulfide- and Thiol-containing regions of yeast glutathione reductase

Cheryl M. Reichert (McBroom), M.D., Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: 1974

The immunochemistry of anti-mannosyl antibodies sharing concanavalin a binding specificity: Further exploration of the concanavalin a carbohydrate combining site

Paul Kosta Tomich, Ph.D.

Mentor: G. Robert Greenberg, Ph.D.

Thesis Defense: 1974

Role of dCMP hydroxymethylase in deoxyribonucleotide metabolism and DNA synthesis in bacteriophage T4 infection

Ronald W. Walenga, Ph.D.

Mentor: William E.M. Lands, Ph.D.

Thesis Defense: 1974

Effects of unsaturated fatty acids on growth and respiration in S. cerevisiae

Donald Jon Bednarczyk, Ph.D.

Mentor: Fedor Medzihradsky, Ph.D.

Thesis Defense: 1975

Drug Transport in the Isolated Rat Retina

Yii-Der Ida Chen (Hladik), Ph.D.

Mentor: Fred Hoch, Ph.D.

Thesis Defense: 1975

Mitochondrial inner membrane properties in hypothyroidism

James Bert Flanegan, Ph.D.

Mentor: G. Robert Greenberg, Ph.D.

Thesis Defense: 1975

Regulation of pyrimidine deoxyribonucleotide biosynthesis b the bacteriophagej T4 DNA replication complex

Patrick John Fleming, Ph.D.

Mentor: Amiya Hajra, Ph.D.

Thesis Defense: 1975

1-alkyl-sn-glycero-3-phosphate: Acyl-CoA acyltransferase in rat brain

Lilian Ming-Te Hsu, Ph.D.

Mentor: George Jourdian, Ph.D.

Thesis Defense: 1975

An analytical ion exchange-gas-liquid chromatographic methodology for studying the glycosides of amino acids in urine in health and disease

David W. C. Law, Ph.D.

Mentor: Lawrence H. Louis, Ph.D.

Thesis Defense: 1975

Purification and properties of a diabetogenic peptide from urine of diabetic patients

Jack Jay Manis, Ph.D.

Mentor: Harvey Whitfield, Ph.D.

Thesis Defense: 1975

Isolation and characterization of a plasmid cointegrate from Salmonella typhimurium

Rachel Myerowitz, Ph.D.

Mentor: George Jourdian, Ph.D.

Thesis Defense: 1975

Biochemical studies on GM1 gangliosidosis Type I skin fibroblasts

Michael Alan Neymark, Ph.D.

Mentor: Fred Hoch, Ph.D.

Thesis Defense: 1975

A comparison of energy production and utilization in normal and hypothyroid rat liver mitochondria

John Beyer Ohlrogge, Ph.D.

Mentor: William E.M. Lands, Ph.D.

Thesis Defense: 1975

Consequences of altered fatty acid composition on the growth and physiology of Escherichia coli

Steven Carl Quay, M.D., Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: 1975

Regulation of branched-chain amino acid transport in bacteria

Leonard Harry Rome, Ph.D.

Mentor: William E. M. Lands, Ph.D.

Thesis Defense: 1975

Mechanisms for the control of fatty acid oxygenation during prostaglandin biosynthesis

Richard T. Ruettinger, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1975

w-hydroxylase from Pseudomonas oleovorans: Roles for nonheme iron and phospholipid in catalysis

David Martin Anderson, Ph.D.

Mentor: William Folk, Ph.D.

Thesis Defense: 1976

Polyoma Virus: DNA Iodination, Endonuclease Hin dIII Resistant Mutants and Virus Rescued From Transformed Cells

Richard David Ball, M.D. Ph.D.

Mentor: Isadore Bernstein, Ph.D.

Thesis Defense: 1976

Histidine-Rich Protein II in the Stratum Corneum - A New Marker of Epidermal Differentiation

Anne Louise Cahill, Ph.D.

Mentor: Fedor Medzihradsky, Ph.D.

Thesis Defense: 1976

Transport and Interaction of Central Nervous System Drugs in Synaptosomes

Kenneth Lyle Campbell, Ph.D.

Mentor: Merle Mason, Ph.D.

Thesis Defense: 1976

The Effects of Neonatal Treatment with o,p’ -DDt on the Development of the Steroidogenic Endocrine System in the Male Rat

Cinda-Sue G. Davis, Ph.D.

Mentor: Bernard Agranoff, Ph.D.

Thesis Defense: 1976

Purification and Characterization of Phosphatidate Phosphohydrolase From a Soluble Fraction of Brain

William L. Dean, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1976

Immunochemical Studies on Liver Microsomal Cytochrome P-450

Louis J. DeFilippi, Ph.D.

Mentor: Donald Hultquist, Ph.D.

Thesis Defense: 1976

A Green Formylheme-Containing Protein From Bovine Red Cells: Purification, Properties, and Reactivity With Peroxides

Carol Cherkis Epstein, Ph.D.

Mentor: Prasanta Datta, Ph.D.

Thesis Defense: 1976

Subunit structure and conformational studies of homoserine dehydrogenase from Rhodospirillum rubrum

Timothy C. Evans, MD., Ph.D.

Mentor: Fred Hoch, Ph.D.

Thesis Defense: 1976

The pyridine nucleotide transhydrogenase of normal and hypothyroid rat liver mitochondria (MSTP)

David Alan Filler, Ph.D.

Mentor: Paul Weinhold, Ph.D.

Thesis Defense: 1976

Calcium-stimulated base exchange reactions of the phospholipids in cardiac microsomes

Leonard Sachs, Ph.D.

Mentor: Isadore Bernstein, Ph.D.

Thesis Defense: 1976

Transcription of epidermal chromatins at different stages of differentiation

Michael Tobes, Ph.D.

Mentor: Merle Mason, Ph.D.

Thesis Defense: 1976

L-Kynurenine aminotransferase and L-alpha-aminoadipate aminotransferase: purification, characterization, and evidence for identity

Bennie Lee Baker, Ph.D.

Mentor: Donald Hultquist, Ph.D.

Thesis Defense: 1977

A Copper-Binding Immunoglobulin from the Serum of a Hypercupremic, Multiple Myeloma Patient: Detection, Purification, Identification, and Characterization

Susan Jaken, Ph.D.

Mentor: Merle Mason, Ph.D.

Thesis Defense: 1977

Purification and characterization of g glutamyl transpeptidase from normal and malignant rat mammary tissue

Robert Lee Sarber, Ph.D.

Mentor: George Jourdian, Ph.D.

Thesis Defense: 1977

Isolation of b-hexosaminidase and a-mannosidase and their use in the determination of the carbohydrate structure of ovumucoid

Ward Whitlock Smith, Jr., Ph.D.

Mentor: Martha Ludwig, Ph.D.

Thesis Defense: 1977

The crystal structure and refinement of clostridium MP flavodoxin in the semiquinone state and some comparisons of the protein in the oxidized, semiquinone and fully reduced states

Keith D. Wilkinson, Ph.D.

Mentor: Charles Williams, Ph.D.

Thesis Defense: 1977

Escherichia coli lipoamide dehydrogenase: Characterization of the two electron reduced state, effects of guanidinium chloride, and substrate inhibition of catalytic activity

Paul Pan-Dai Fan, Ph.D.

Mentor: Prasanta Datta, Ph.D.

Thesis Defense: 1978

Sialyltransferase in BHK cells

Martin Edward Hemler, Ph.D.

Mentor: William E. M. Lands, Ph.D.

[email protected]

Thesis Defense: 1978

Purification, stabilization, and autoregulation of cyclooxygenase-catalyzed prostaglandin formation

Richard J. Kirschner, Ph.D.

Mentor: Jules Shafer, Ph.D.

Thesis Defense: 1978

Reactions of trypsin and iodoacetate with 3T3 cells A cell surface protease-binding protein; cell density-dependent changes in glyceraldehyde 3-phosphate dehydrogenase and other thiol proteins; and formation and exit of cellular alkylated glutathione

Pamela Moore Mattes, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: 1978

Characterization and regulation of amino acid transport in cultured CHO cells; a role for the aminoacyl-transfer-RNA synthetase in transport regulation

Lee Andrew Murphy, Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: 1978

Purification and characterization of a family of a-D-galactopyranosyl binding isolectins from Bandeiraea simplicifolia seeds

Shelley Ruth Slaughter, Ph.D.

Mentor: Donald Hultquist, Ph.D.

Thesis Defense: 1978

Studies of cytochrome b5 in erythrocytes and in immature erythroid cells

Jeffrey J. Vanderbilt, Ph.D.

Mentor: John R. Wiseman, Ph.D.

Thesis Defense: 1978

Bicyclo [4.2.3] deca-1, 5-diene, tricyclo [5.4.0.04,8] decane, and high pressure effects on diels-alder reactions

Sharon Anne Boylan, Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: 1979

L-Threonine Dehydrogenase From Escherichia coli K-12 - Purification, Properties, and Role in L-Threonine Catabolism

Subhash C. Gupta, M.D., Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: 1979

Identification, characterization and significance of 2-keto-4-hydroxyglutarate dehydrogenase activity

Paul Edward Gurba, Ph.D.

Mentor: William E. M. Lands, Ph.D.

Thesis Defense: 1979

Unsaturated fatty acid influence on cellular and mitochondrial proliferation in S. cerevisiae

David W. Jayme, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: 1979

Regulation of neutral amino acid transport in Chinese hamster ovary cells

Frederick A. Johnson, Ph.D.

Mentor: Jules Shafer, Ph.D.

Thesis Defense: 1979

The ionization behavior of the imidazole and thiol groups at the active site of papain

Gregory J. McClune, Ph.D.

Mentor: James A. Fee, Ph.D.

Thesis Defense: 1979

Iron catalyzed superoxide dismutation

Mary Helen M. Mayo, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: 1979

Leucine transport in Escherichia coli: Isolation and charachterization of transport mutants and studies on regulation and energization

Steven T. Olson, Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: 1979

Purification and properties of the flavoenzyme D-Lactate dehydrogenase from Megasphaera elsdenii and an investigation of its suicide inactivation by 2-hydroxy-3-butynoate

Lucy Jean Sannes, Ph.D.

Mentor: Donald Hultquist, Ph.D.

Thesis Defense: 1979

Kinetics and mechanism of methemoglobin reduction

Lawrence M. Schopfer, Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: 1979

Studies on the mechanism of oxidation and reduction of melilotate hydroxylase

Daniel Evan Schwass, Ph.D.

Mentor: Halvor Christensen, Ph.D.

Thesis Defense: 1979

Adaptive regulation of neutral amino acid transport in primary cultures of hepatocytes

John Storrs French, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1979

NADPH-cytochrome P-450 reductase: Properties and interactions with other microsomal components

1980s

Narlin Bennet Beaty, Ph.D.

Mentor: David Ballou, Ph.D.

Thesis Defense: 1980

Enzyme Mechanism of Microsomal N, S-Monooxygenase

Paul Andrew Davis, Ph.D.

Mentor: Amiya Hajra, Ph.D.

Thesis Defense: 1980

Studies of the Biosynthesis of Alkyl Dihydroxyacetone-3-Phosphate

Richard P. Kitson, Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: 1980

Bovine kindey 2-keto-4-hydroxyglutarate aldolase: Purification, characterization, and investigation of catalytically active aminoacyl residues

Christopher L. Jones, Ph.D.

Mentor: Amiya Hajra, Ph.D.

Thesis Defense: 1980

Studies on acyl coenzyme A: Dihydroxyacetone phosphate acyltransferase

Daniel D. Oprian, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: 1980

Kinetics of reduction of cytochrome P-450LM4 and NADPH-cytochrome p-450 reductase

Linda Sue Park, Ph.D.

Mentor: Prasanta Datta, Ph.D.

Thesis Defense: 1980

The regulation of biodegradative threonine dehydratase of Escherichia coli K12 by intermediary metabolites

Barry Paul Peters, Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: 1980

Bandeiraea simplicifolia B4 isolectin-a probe for a-D-galactopyranosyl groups in mammalian tissues-their occurrence in basement membranes

Yuan-Kai Tsao, Ph.D.

Mentor: William E. M. Lands, Ph.D.

Thesis Defense: 1980

Effects of Positional Isomers of Trans-Octadecenoate and Arachidonate on the Growth and Metabolism of Escherichia coli

Susan Leslie Berent, Ph.D.

Mentor: Norman Radin, Ph.D.

Thesis Defense: January 1, 1981

Glucocerebrosidase Activator Protein of Bovine Spleen

James E. Bishop, Ph.D.

Mentor: Amiya Hajra, Ph.D.

Thesis Defense: January 1, 1981

Biosynthesis of Long Chain Alcohols in Developing Rat Brain

Charles John Daniels, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: January 1, 1981

Synthesis and Processing of the Periplasmic Leucine Transport Proteins of Escherichia coli

Paul F. Fitzpatrick, Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: January 1, 1981

Studies on the mechanism of D-amino acid oxidase

Deborah L. Higgins, Ph.D.

Mentor: Jules Shafer, Ph.D.

Thesis Defense: January 1, 1981

Dysfibrinogenemias: Probes for establishing relationships between the structure of fibrinogen and its function in blood coagulation

Paul Ralph Housley, Ph.D.

Mentor: Harvey Whitfield, Ph.D.

Thesis Defense: January 1, 1981

A Salmonella typhimurium rho mutant with defective rho-associated transcription termination activity

William Bustin Mattes, Ph.D.

Mentor: G. Robert Greenberg, Ph.D.

Thesis Defense: January 1, 1981

Effect of DNA damage by mitomycin C or ultraviolet irradiation on bacteriophage T4 deoxyribonucleotide synthetase

Garabed Gary Sahagian, Ph.D.

Mentor: George Jourdian, Ph.D.

Thesis Defense: January 1, 1981

Receptor-mediated uptake of lysosomal enzymes

Morris F. White, Jr., Ph.D.

Mentor: Halvor Christensen, Ph.D.

Thesis Defense: January 1, 1981

The transport of cationic amino acids across the plasma membrane of cultured mammalian cells

Shaun Dennis Black, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: January 1, 1982

Structural Studies on Hepatic Microsomal NADPH-Cytochrome P-450 Reductase

Susan Colette Daubner, Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: September 1, 1982

Purification and Properties of Methylenetetrahydrofolate Reductase From Pig Liver

Carol Sue Federiuk, M.D., Ph.D.

Mentor: Jules Shafer, Ph.D.

Thesis Defense: July 1, 1982

Characterization of the catalytic pathway of the pyridoxal 5’-phosphate dependent enzyme D-serine dehydratase

Curtis J. Henrich, Ph.D.

Mentor: David Aminoff, Ph.D.

Thesis Defense: November 1, 1982

Isolation and characterization of a human erythrocyte senescence factor

Regina M. Toomey Malczewski, Ph.D.

Mentor: Harvey Whitfield, Ph.D.

Thesis Defense: June 1, 1982

Biochemical characterization of Chinese hamster lung cell mutants defective in the electron transport chain

Raymond J. Metz, Ph.D.

Mentor: Norman Radin, Ph.D.

Thesis Defense: January 1, 1982

The demonstration, purification, and characterization of a glucosylceramide transfer protein

Michael E. O’Donnell, Ph.D.

Mentor: Charles Williams, Ph.D.

Thesis Defense: October 1, 1982

Mechanistic features of Escherichia coli thioredoxin reductase catalysis

Therese B. Timmons (Brozowski), Ph.D.

Mentor: Paul Weinhold, Ph.D.

Thesis Defense: October 1, 1982

Regulation of phospholipid synthesis in fetal and adult lung

Robert Leslie Brooks, Ph.D.

Mentor: Paul Weinhold, Ph.D.

Thesis Defense: January 1, 1983

Characterization and Properties of Triacylglycerol Acid Lipase from Fetal and Adult Rat Lung

Steven V. Fischel, Ph.D.

Mentor: Fedor Medzihradsky, Ph.D.

Thesis Defense: April 1, 1983

Heterogeneity of opiate receptor binding in cerebral membranes, neurons, and glia from rat brain

Robert C. Landick, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: January 1, 1983

The LIV-1 gene cluster of Escherichia coli

Mary Jane Makowske, Ph.D.

Mentor: Halvor Christensen, Ph.D.

Thesis Defense: January 1, 1983

Anionic amino acid transport across the plasma membrane of cultured rat hepatocytes and hepatoma cell lines

Joseph C. Miller, Ph.D.

Mentor: Paul Weinhold, Ph.D.

Thesis Defense: January 1, 1983

Synthesis of dipalmitoylphosphatidylcholine by cholinephosphoransferase in fetal and adult rat lung

Gary Keith Powell, Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: January 1, 1983

Nonprotein amino acids of peanuts (Arachis hypogaea): Enzymatic, metabolic and translocation studies with 4-methyleneglutamic acid and 4-methyleneglutamine

David Duncan Roberts, Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: January 1, 1983

Structural and functional analyses of the lima bean lectin

Dorothy Anne Schafer, Ph.D.

Mentor: Donald Hultquist, Ph.D.

Thesis Defense: May 1, 1983

Proteolysis of microsomal cytochrome b5 and cytochrome b5 reductase by a carboxyl protease from reticulocytes

Audrey Faye Seasholtz, Ph.D.

Mentor: G. Robert Greenberg, Ph.D.

Thesis Defense: January 1, 1983

Bacteriophage T4 DNA topoisomerase: Purification properties and interaction with the membrane

Cynthia C. Barchfeld (Rothschild), Ph.D.

Mentor: Fedor Medzihradsky, Ph.D.

Thesis Defense: August 1, 1984

Ligand Interaction with Opiate Receptor, and Receptor-Effector Coupling in Brain Slices

Edward I. Cullen, Ph.D.

Mentor: Fedor Medzihradsky, Ph.D.

Thesis Defense: January 1, 1984

Transport of Propranolol and Other Lipophilic Amines in Synaptosomes and Granulocytes

Kristina Maria Detmer, Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: January 1, 1984

Studies on the Mechanism of Phenol Hydroxylase

Lee D. Gorsky, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: January 1, 1984

Studies on the Activation and Reduction of Dioxygen By Cytochrome P-450

John M. Hilfinger, Ph.D.

Mentor: Prasanta Datta, Ph.D.

Thesis Defense: January 1, 1984

A study of growth regulation in 3T3 fibroblasts

Jaulang Hwang, Ph.D.

Mentor: Jairam K.M. Menon, Ph.D.

Thesis Defense: January 1, 1984

Characterization of the receptors for luteinizing hormone/human chorionic gonadotropin and lipoproteins in the luteinized rat ovary

Michelle R. Lennartz, Ph.D.

Mentor: George Jourdian, Ph.D.

Thesis Defense: January 1, 1984

Isolation and partial characterization of oligosaccharides on b-galactosidase

Patrick Gerard Quinn, Ph.D.

Mentor: Anita Payne, Ph.D.

Thesis Defense: January 1, 1984

Cholesterol depletion and regulation of microsomal cytochrome p-450 enzymes by steroids and oxygen in desensitized leydig cells

Richard C. Stewart, Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: January 1, 1984

Interactions of the inhibitors arsenite and 8-bromoxanthine with the MO center of xanthine oxidase

James Wilson, Ph.D.

Mentor: William Kelley, Ph.D.

Thesis Defense: January 1, 1984

Human Hypoxanthine-Guanine Phosphoribosyl Transferase: Molecular Basis of the Enzyme Deficiency States

Paul Alfred Craig, Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: January 1, 1985

L-Threonine Dehydrogenase frm Escherichia coli K-12 Thiol-Dependent Activation by Mn2+ and the Role of Sulfhydryl Groups in Structure and Function

Kenneth C. Jones, Ph.D.

Mentor: David Ballou, Ph.D.

Thesis Defense: January 1, 1985

Nature of the 4a-flavinhydroperoxide of microsomal flavin-containing monooxygenase

Peter George Zaphiropoulos, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: January 1, 1985

Isolation and characterization of a novel cytochrome P-450-like gene

Verna Frasca, Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: January 1, 1986

Purification and properties of methionine synthase from Escherichia coli B

Thomas J. Goss, Ph.D.

Mentor: Prasanta Datta, Ph.D.

Thesis Defense: January 1, 1986

Cloning and analysis of the tdc region of Escherichia coli K-12

Carlos Rodriguez, Ph.D.

Mentor: Donald Hultquist, Ph.D.

Thesis Defense: January 1, 1986

Purification and characterization of rabbit reticulocyte cathepsin D

Markos Georgiou, Ph.D.

Mentor: Anita Payne, Ph.D.

Thesis Defense: January 1, 1987

Regulation of cholesterol side-chain cleavage enzyme and testosterone production in Leydig cells

David Allen Giegel, Ph.D.

Mentors: Vincent Massey, Ph.D.; Charles H. Williams, Ph.D.

Thesis Defense: January 1, 1987

Active site studies of L-lactate-2-monooxygenase

James B. Howell, Ph.D.

Mentor: Margaret Hunter, Ph.D.

Thesis Defense: January 1, 1987

The interaction of a2 macroglobulin with trypsin, chymotrypsin, plasmin, and papain

Randall N. Knibbs, Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: January 1, 1987

Studies on the structure and biological function on the carbohydrate moiety of the extracellular matrix component laminin

Mary Jon Maliarik, Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: January 1, 1987

Studies on the structural and ligand binding properties of N-acetylgalactosamine specific lectins

Timothy E. O’Toole, Ph.D.

Mentor: William Kelley, Ph.D.

Thesis Defense: January 1, 1987

Human Adenine Phosphoribosyltransferase: Molecular Characterization of the Normal and Deficiency states

Chris John Vlahos, Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: January 1, 1987

Active site studies of Escherichia coli 2-keto-4-hydroxyglutarate aldolase

Beverly Long Davidson, Ph.D.

Mentor: William Kelley, Ph.D.

Thesis Defense: January 1, 1988

The Genetic Basis of Hypoxanthine Guanine Phosphoribosyltransferase Deficiency States in Humans

Xinxin Ding, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: January 1, 1988

Properties and Differential Expression of Multiple Forms of Cytochrome P-450

Jacalyn Marla Green (Tschirhart), Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: January 1, 1988

Probing the cellular role of the folylpolyglutamate chain: studies of methylenetetrahydrofolate dehydrogenase and methylenetetrahydrofolate reductase

Michelle Marceau, Ph.D.

Mentor: Jules Shafer, Ph.D.

Thesis Defense: January 1, 1988

Active site residues of Escherichia coli D-serine dehydratase, a model vitamin B6 (pyridoxal 5’-phosphate) enzyme

Louise Marian Perkins, Ph.D.

Mentor: Anita Payne, Ph.D.

Thesis Defense: September 15, 1988

Hormonal and Genetic Regulation of Steroidogenic P450 Enzymes In Leydig Cells

Keith Owen Webber, Ph.D.

Mentor: Amiya Hajra, Ph.D.

Thesis Defense: January 1, 1988

Dihydroxyacetone phosphate acyltransferase

Barbara H. Zimmermann, Ph.D.

Mentor: James Fee, Ph.D.

Thesis Defense: January 1, 1988

Studies of respiratory proteins from the thermophilic aerobic bacterium, Thermus thermophilus, and purification of cytochrome ba3, a new terminal oxidase

George S. Campbell, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: December 1, 1989

Genetic and Biochemical Studies of Amino Acid Transport in Chinese Hamster Ovary Cells

Kenneth G. Hadlock, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: January 1, 1989

Characterization of the T-antigen content of simian virus 40 viral transcription complexes

Jonathan Mark Huibregtse, Ph.D.

Mentor: David Engelke, Ph.D.

Thesis Defense: January 1, 1989

Protein-DNA interactions at tRNA gene promoter regions and at an RNA polymerase II upstream activation sequence in yeast nuclei

Kevin Allen Hutchison, Ph.D.

Mentor: Irving Fox, Ph.D.

Thesis Defense: January 1, 1989

Characterization of adenosine binding proteins in human placental membranes

Shahrokh Charles Khani, M.D., Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: January 1, 1989

Studies on the structure and regulation of two highly similar genes in the alcohol-inducible cytochrome P-450 subfamily

John R. Kitchen, Jr., Ph.D.

Mentor: Isadore Bernstein, Ph.D.

Thesis Defense: January 1, 1989

Mechanism for accommodation to cadmium exposure in Escherichia coli B

Andrew J. Prongay, Ph.D.

Mentor: Charles Williams, Ph.D.

Thesis Defense: January 1, 1989

Mechanistic studies of Escherichia coli thioredoxin reductase: Characterization of mutations of the two active site cysteines

Stephen J. Rinderle, Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: January 1, 1989

Isolation and properties of amaranthin, a lectin which recognizes the T- (or cryptic T) antigen

Christopher E. Rohlman, Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: January 1, 1989

Response to folate stress in Escherichia coli

Joel Samuel Tabb, Ph.D.

Mentors: Halvor Christensen, Ph.D.; Dale Oxender Ph.D.

Thesis Defense: January 1, 1989

Photoaffinity and protein-modification studies on the system L and system T amino acid transporters in mammalian cells

Marc Gregory Taylor, Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: January 1, 1989

Mechanistic studies on phenol hydroxylase

Min-Jen Tseng, Ph.D.

Mentor: G. Robert Greenberg, Ph.D.

Thesis Defense: January 1, 1989

Expression of genes encoding bacteriophage T4 ribonucleoside diphosphate reductase

Qing-Yu Zhang, Ph.D.

Mentor: Jairam K.M. Menon, Ph.D.

Thesis Defense: January 1, 1989

Studies on gonadotropin receptor of rat ovary and testis

1990s

Mark D. Adams, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: April 17, 1990

Structure-Function Studies on the Leucine-Binding Proteins of Escherichia coli

Pierre Brissette, Ph.D.

Mentor: David Ballou, Ph.D.

Thesis Defense: September 16, 1990

Mechanism of Two Flavoenzymes Involved in the Degradation of Vitamin B6 in Bacteria: MHPC Oxygenase and 5-Pyridoxic Acid Oxygenase

Robert Clair Casad Jr., Ph.D.

Mentor: Richard Adelman, Ph.D.

Thesis Defense: January 1, 1990

Studies with Somatostatin and Aging

William Robert Epperly Jr., Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: September 14, 1990

Investigation of Active-Site Residues and Sequence Homology in E. coli L-Threonine Dehydrogenase

Clair Frances Evans, Ph.D.

Mentor: David Engelke, Ph.D.

Thesis Defense: January 1, 1990

Interactions of Saccharomyces cerevisiae transcription factor with promoters for RNA polymerases II and III

Thomas J. Graddis, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: January 1, 1990

Identification and characterization of the membrane components of the LIV-I transport system of Escherichia coli

Maomi Li, M.D., Ph.D.

Mentor: George Jourdian, Ph.D.

Thesis Defense: January 1, 1990

Characterization of bovine testis mannose 6-phosphate receptors

Ann Elizabeth Remmers, Ph.D.

Mentor: Fedor Medzihradsky, Ph.D.

Thesis Defense: January 1, 1990

Modulation of opioid receptor binding by G protein and membrane lipid

Glenn Mark Anderson, Ph.D.

Mentor: Svend Freytag, Ph.D.

Thesis Defense: January 1, 1991

The Role of Transcription Factors Sp1 and TFIID in Transcription of the Human Argininosuccinate Synthetase Gene

Lawrence Argetsinger, Ph.D.

Mentor: Jules Shafer, Ph.D.

Thesis Defense: January 14, 1991

The Reversible and Irreversible Autophosphorylations of Insulin Receptor Kinase and Isolation of the Phosphorylated Form of Rous Sarcoma Virus Tyrosine Kinase

Pedro J. Bonilla, Ph.D.

Mentors: Bryant Villeponteau, Ph.D.; Svend Freytag, Ph.D.

Thesis Defense: July 25, 1991

SV40 Enhancer activation of the human argininosuccinate synthetase promoter

Carl C. Correll, Ph.D.

Mentor: Martha Ludwig, Ph.D.

Thesis Defense: January 14, 1991

Structure Determination and Analysis of an Iron-Sulfur Flavoprotein; Phthalate Dioxygenase Reductase

Steven Arthur Haney, Ph.D.

Mentor: Dale Oxender, Ph.D.

Thesis Defense: June 26, 1991

Regulation of branched-chain amino acid transport in Escherichia coli by attenuation and repression

Thomas J. Hornyak, M.D., Ph.D.

Mentor: Jules Shafer, Ph.D.

Thesis Defense: January 14, 1991

Activation of Blood Coagulation Factor XIII and Interactions of Factor XIII With Fibrinogen and Fibrin

Jane Renee Larson, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: September 17, 1991

Role of the hydrophobic NH2-terminal segment of alcohol-inducible cytochrome P-450 studied by heterologous expression

Jae-Yong Lee, Ph.D.

Mentor: David Engelke, Ph.D.

Thesis Defense: March 13, 1991

Characterization of Saccharomyces cerevisiae Nuclear RNase P and Its RNA Subunit

Andrew S. Niedzielski, Ph.D.

Mentor: Jochen Schacht, Ph.D.

Thesis Defense: July 22, 1991

Phosphoinositide metabolism and second messenger generation in the cochlea

Michael C. Naski, M.D., Ph.D.

Mentor: Jules Shafer, Ph.D.

Thesis Defense: January 1, 1991

Kinetics of thrombin-catalyzed formation of fibrin and factor XIIIa during blood clotting(MSTP)

Elizabeth (Liz) Starr Roberts (Kirchhoff), Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: August 19, 1991

Role of cytochrome P-450 in the metabolism of lipid hydroperoxides, retinoids, and xenobiotic aldehydes

Cheryl Wistrom, Ph.D.

Mentor: Bryant Villeponteau, Ph.D.

Thesis Defense: August 16, 1991

Gene Expression During Senescence in Human Fibroblasts

Kenneth Chahine, Ph.D.

Mentor: Daniel Goldman, Ph.D.

Thesis Defense: September 15, 1992

Depolarization Regulates the Expression of the Nicotinic Acetylcholine Receptor Subunits

Bruce Carter, Ph.D.

Mentor: Fedor Medzihradsky, Ph.D.

Thesis Defense: September 24, 1992

Mechanisms of Opioid Signal Transduction in SH-SY5Y Neural Cells

Yen-Wen Chen, Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: May 29, 1992

Structure/Function Interrelationships of Threonine Dehydrogenase and 2-Amino-3-Ketobutyrate CoA Lyase, Primary Enzymes for Threonine Metabolism in Escherichia coli

Kevin Ferreri, Ph.D.

Mentor: Jairam K.M. Menon, Ph.D.

Thesis Defense: January 30, 1992

Studies on the Regulation and Structure of the Ovarian High Density Lipoprotein Receptor

Frank Hoover, Ph.D.

Mentor: Daniel Goldman, Ph.D.

Thesis Defense: October 5, 1992

Neural Nicotinic acetycholine receptor and GAP-43 developing mammalian retina

Dan Francis Lazar, Ph.D.

Mentor: Fedor Medzihradsky, Ph.D.

Thesis Defense: October 1, 1992

Membrane modulation of opioid receptor mechanisms

Chung-Hee Lee, Ph.D.

Mentor: Amiya Hajra, Ph.D.

Thesis Defense: January 23, 1992

The Origins and Metabolism of Diacylglycerol and Phosphatidate Formed Upon Stimulation of Neural Receptors

Stacey Anne Minskoff, Ph.D.

Mentor: M. Greenberg, Ph.D.

Thesis Defense: December 14, 1992

Regulation of Phospholipid Metabolism in Yeast

Mohammad Pashmforoush, M.D., Ph.D.

Mentors: William Kelley, Ph.D.; David Engelke, Ph.D.

Thesis Defense: September 28, 1992

Expression of the Human HPRT Gene in Neural Tissue

Michael J. Pikaart, Ph.D.

Mentor: Bryant Villeponteau, Ph.D.

Thesis Defense: September 4, 1992

Active Chromatin: Biochemical and Genetic Determinants of Chromatin Structure

J. Jeffery Plomer, Ph.D.

Mentor: Ari Gafni, Ph.D.

Thesis Defense: May 21, 1992

Studies on the Mechanisms of Denaturation and Renaturation of Glucose-6-Phosphate Dehydrogenase From Leuconostoc mesenteroides

Robert J. Pogulis, Ph.D.

Mentors: Svend Freytag, Ph.D. ; Bryant Villeponteau, Ph.D.

Thesis Defense: December 9, 1992

Identification of CIS-acting Elements and Trans-acting Factors Required for Maximal Activity of the Mouse pro-a2(I) Collagen Enhancer

James Sullivan Sumner, Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: November 11, 1992

Structural and mechanistic investigations of methylenetetrahydrofolate reductase and their functional implications

Peter John Tummino, Ph.D.

Mentor: Ari Gafni, Ph.D.

Thesis Defense: September 18, 1992

Studies of Adenine Nucleotide Translocase in Mitochondria and in Detergent Micelles

Beom-Seok Yang, Ph.D.

Mentor: Svend Freytag, Ph.D.

Thesis Defense: January 27, 1992

The Regulation of Gene Expression by Oncogene MYC and Cell Growth State: The Involvement of Transcription and DNA-Replication Factor CTF/NF-1

Geri Lynn Youngblood, Ph.D.

Mentor: Anita Payne, Ph.D.

Thesis Defense: January 30, 1992

Molecular and Genetic Characterization of Steroidogenic P450 Enzymes in The Mouse

Shu-Jen Chen, Ph.D.

Mentors: James M. Wilson, PhD.; Jairam K.M. Menon, Ph.D.

Thesis Defense: November 23, 1993

Virus-Mediated Gene Transfer of Recombinant Soluble Adhesion Molecules to the Vessel Wall and Synovium

Robert Clubb, Ph.D.

Mentors: Gerhard Wagner, Ph.D.; Martha Ludwig, Ph.D.

Thesis Defense: October 4, 1993

Application and Development of Multi-Dimensional NRM Spectroscopic Techniques: The Solution Structure Determination of the Cyclophilin-type Peptidyl Prolyl Isomerase.

James Thomas Drummond, Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: October 4, 1993

Nitrous Oxide Inactivation of Methionine Synthase: Characterization of the Chemistry Yields and Ultra-Low Resolution Structural Model for Catalysis

Brian Richard Ernsting, Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: September 7, 1993

The LRP Regulon of Escherichia coli

Jennifer A. Hunt, Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: November 17, 1993

Xanthine Oxidase/Dehydrogenase: A Reversible Enzyme

Michael Louis Leski, Ph.D.

Mentor: Bernard Agranoff Ph.D.

Thesis Defense: April 28, 1993

Purification and characterization of the goldfish regeneration-associated proteins gp68/70

John Paul Marcus, Ph.D.

Mentor: Eugene Dekker, Ph.D.

Thesis Defense: February 11, 1993

Metabolic and mechanistic studies on threonine degradation in Escherichia coli via the L-threonine dehydrogenase-initiated pathway

Ute Muh, Ph.D.

Mentors: Charles H. Williams, Ph.D.; Vincent Massey, Ph.D.

Thesis Defense: March 23, 1993

Lactate oxidase: Expression of the Gene in Escherichia coli and Studies of the Reaction Mechanism Through Active Site Mutations

Bruce Allan Palfey, Ph.D.

Mentors: Vincent Massey, Ph.D.; Dave Ballou, Ph.D.

Thesis Defense: November 23, 1993

Studies on the flavoprotein para-hydroxybenzoate hydroxylase using site-directed mutants and solvent isotope effects

Hwei-Ming Peng, Ph.D.

Mentor: Minor J. Coon, Ph.D.

Thesis Defense: February 16, 1993

Developmental Regulation and Biochemical Properties of Nasal and Hepatic p-450 Cytochromes

Kimberly Sue Quandt, Ph.D.

Mentor: Donald Hultquist, Ph.D.

Thesis Defense: November 2, 1993

Flavin reductase: Structural studies and tissue distribution

Zhiwei Song, Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: May 10, 1993
Expression and function of cell adhesion molecules in adherent and non-adherent ehrlich ascites tumor cells

Katherine T. Tamai, PhD.

Mentor: Dennis Thiele, Ph.D.

Thesis Defense: September 22, 1993

Transcriptional regulation and function of yeast metallothionein during oxidative stress

Liqian Zhang, Ph.D.

Mentor: Gary Nabel, Ph.D.

Thesis Defense: October 4, 1993

The Regulation of the Expression of Human Interleukin-2 Gene

Pengbo Zhou, Ph.D.

Mentor: Dennis Thiele, Ph.D.

Thesis Defense: March 17, 1993

Metal-Regulated Gene Transcription in the Yeast Candida clabrata

Eric John Baude, Ph.D.

Mentor: Michael Uhler, Ph.D.

Thesis Defense: July 21, 1994

Analysis of Protein Kinase Inhibitor Interactions With cAMP-Dependent Protein Kinase

Trent Clarke, Ph.D.

Mentor: Anita Payne, Ph.D.

Thesis Defense: November 8, 1994

Characterization of the cDNAs, genes, and expressed proteins of several members of the mouse 3-beta-hydroxysteroid dehydrogenase gene family

Hebe Guardiola-Diaz, Ph.D.

Mentor: Audrey Seasholtz, Ph.D.

Thesis Defense: April 29, 1994

Regulation of human corticotropin-releasing hormone gene expression

Nancy Hopkins-Evans, Ph.D.

Mentor: Charles Williams, Ph.D.

Thesis Defense: May 27, 1994

Studies of Escherichia coli liopoamide dehydrogenase lacking the redox active disulfide: C44s and C49S

Elizabeth T. Jordan, Ph.D.

Mentor: Irwin Goldstein, Ph.D.

Thesis Defense: April 18, 1994

Recombinant lima bean lectin: cloning, expression, characterization and mutational analysis

Patricia Viola Racenis, Ph.D.

Mentors: Amiya Hajra, Ph.D.; M. Greenberg Ph.D.

Thesis Defense: October 4, 1994

Phosphatidate biosynthesis in the yeast Saccharomyces cerevisiae

Anthony J. Tranguch, M.D., Ph.D.

Mentor: David Engelke, Ph.D.

Thesis Defense: June 14, 1994

Structural Analyses of Nuclear RNase P RNA from Yeast

Heather Kay Webb, Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: December 14, 1994

Mechanistic insight into serine hydroxymethyltransferase through the use of substrate analogs

Kimberly Ann White, Ph.D.

Mentor: Michael Marletta, Ph.D.

Thesis Defense: July 29, 1994

Studies of the heme environment and electron flow in the inducible murine macrophage nitric oxide synthase

Jinghua Yu, Ph.D.

Mentors: Bryant Villeponteau, Ph.D.; Michael D. Uhler, Ph.D.

Thesis Defense: November 28, 1994

The effects of a b-globin matrix attachment region (MAR) on gene expression

Constantinos Broustas, Ph.D.

Mentor: Amiya Hajra, Ph.D.

Thesis Defense: April 7, 1995

Studies on Rat Brain Cytosolic Fatty Acyl Coenzyme A Thioesterase

Catherine L. Drennan, Ph.D.

Mentor: Martha Ludwig, Ph.D.

Thesis Defense: January 20, 1995

Crystallographic studies of FMN and Vitamin B12 Dependent Enzymes: Flavodoxin and Methionine Synthase

George T. Gassner, Ph.D.

Mentor: David Ballou, Ph.D.

Thesis Defense: February 2, 1995

Mechanistic Studies of the Phthalate Dioxygenase System

Brett William Lennon, Ph.D.

Mentor: Charles Williams, Ph.D.

Thesis Defense: January 25, 1995

Study of the reductive and oxidative half reactions of Escherichia coli Thioredoxin reductase: Implications for catalysis

Eileen Pagan-Ramos, Ph.D.

Mentor: David Engelke, Ph.D.

Thesis Defense: December 15, 1995

Mutational analyses of yeast nuclear Rnase P

Michael Kerr Richards, M.D., Ph.D.

Mentor: Michael Marletta, Ph.D.

Thesis Defense: September 20, 1995

Overexpression and Purification of neuronal Nitric Oxide Synthase From a Baculovirus Expression System: Characterization of Two C415 Heme-Binding mutants

James R. Stone, M.D., Ph.D.

Mentor: Michael Marletta, Ph.D.

Thesis Defense: June 9, 1995

Activation of Soluble Guanylate Cyclase by Nitric Oxide: Spectroscopic and Kinetic Studies Reveal an Unusual Heme Environment

Mark Stanley Szczypka, Ph.D.

Mentor: Dennis Thiele, Ph.D.

Thesis Defense: May 10, 1995

Metal Homeostasis and Metal-Regulated Gene Expression in Yeast

Thomas R. Transue, Ph.D.

Mentor: Mark Saper, Ph.D.

Thesis Defense: September 28, 1995

X-ray Crystal Structures of Amaranthin: Ligand-Free and in Complex with the T-Antigen Disaccharide

Daniel Wade Walke, Ph.D.

Mentor: Daniel Goldman, Ph.D.

Thesis Defense: October, 1995

Molecular Mechanisms Involved in Regulation of Nicotinic Acetylcholine Receptor Genes by Muscle Activity

Daniel N. Cortright, Ph.D.

Mentor: Audrey Seasholtz,

Thesis Defense: September 30, 1996

Characterization of the Corticotropin-Releasing Hormone-Binding Protein

Julio C. Gonzalez, M.D., Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: August 23, 1996

Studies on Cobalamin-Independent Methionine Synthase From Escherichia coli: A Zinc Metalloenzyme

David Michael Hoover, Ph.D.

Mentor: Martha Ludwig, Ph.D.

Thesis Defense: November 14, 1996

Thermodynamic and Structural Studies of the Interaction of Flavodoxin and Methionine Synthase from Escherichia coli

Adam Richard Johnson, Ph.D.

Mentors: Eugene E Dekker, Ph.D.; Donald E Hultquist, Ph.D.

Thesis Defense: January 11, 1996

Structure/Function Interrelationships of Escherichia coli L-Threonine Dehydrogenase

Deborah Lynn Lu, Ph.D.

Mentor: Jairam K.M. Menon, Ph.D.

Thesis Defense: January 31, 1996

Post-transcriptional control of lutropin/choriogonadotropin receptor in the ovary: identification and characterization of a receptor-specific mRNA binding protein

Heidi L. Schubert, Ph.D.

Mentor: Jack E. Dixon, Ph.D.

Thesis Defense: March 24, 1996

Structure of the Yersinia Protein Tyrosine Phosphatase: Evidence for a Ligand-Induced Conformational Change

Pimchai Chaiyen, Ph.D.

Mentors: Vincent Massey, Ph.D.; Dave Ballou, Ph.D.

Thesis Defense: July 8, 1997

2-Methyl-3-Hydroxypyridine-5-Carboxylic Acid Oxygenase: Thermodynamics, Kinetics, Substrate Analogs and Gene Cloning

James D. Fessenden, Ph.D

Mentor: Jochen Schacht, Ph.D.

Thesis Defense: August 14, 1997

The Characterization of the Nitric Oxide/Cyclic GMP Pathway in the Auditory System

Christopher M. Harris, Ph.D.

Mentor: Vincent Massey, Ph.D.

Thesis Defense: August 7, 1997

Transient and Pre-Steady-State Kinetic Analyses of Xanthine Oxidoreductase

Eric Matthew Priuska, Ph.D.

Mentor: Jochen Schacht, Ph.D.

Thesis Defense: March 24, 1997

The Mechanism of Free Radical Formation by Gentamicin: Implications for Ototoxicity

Christian Weber, Ph.D.

Mentor: Martha Ludwig Ph.D.

Thesis Defense: November 3, 1997

The X-Ray Structure Analysis of CTP:Glycerol-3-Phosphate Cytidylyltransferase From Bacillus subtilis

Don Edward (Buddy) Wiese II, M.D., Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: September 10, 1997

Interactions of the leucine-responsive regulatory protein with the promoter region of the gltBDF operon of Escherichia coli specifying glutamate synthase (MSTP)

Jirundon Yuvaniyama, Ph.D.

Mentor: Mark Saper, Ph.D.

Thesis Defense: April 15, 1997

X-ray Crystal Structure of Human VH1-Related Dual Specificity Phosphatase

Larry Dwayne Adams, Ph.D.

Mentor: Daniel Goldman, Ph.D.

Thesis Defense: May 22, 1998

Calcium and cAMP-Dependent Second Messenger Systems Regulating Nicotinic Acetylcholine Receptor Expression

David A. Ammar, Ph.D.

Mentor: Debra Thompson, Ph.D.

Thesis Defense: February 6, 1998

Cloning of a Type 2 Neuropeptide Y Receptor and Characterization of Neuropeptide Y Responses in the Retinal Pigment Epithelium of the Eye

John Weber Denninger, M.D., Ph.D.

Mentor: Michael Marletta, Ph.D.

Thesis Defense: September 3, 1998

Structure and Function Relationships in the Soluble Guanylate Cyclase: Activation by YC-1, Carbon Monoxide, and Nitric Oxide

Xiao-Dong Liu, M.D., Ph.D.

Mentor: Dennis Thiele, Ph.D.

Thesis Defense: November 16, 1998

Stress regulation of heat shock transcription factors

Robert C. Morshauser, Ph.D.

Mentor: Erik Zuiderweg, Ph.D.

Thesis Defense: October 26, 1998

High dimensionality NMR experiments with improved spectral resolution applied to the complete structure determination of the molecular chaperone HSC-70 (heat shock cognate, 70 KDA) substrate binding domain

Aileen Nicoletti, Ph.D.

Mentor: Debra Thompson, Ph.D.

Thesis Defense: September 4, 1998

Cloning and characterization of the human RPE65 gene: A model for regulation of gene expression in the retinal pigment epithelium

Keith Andrew Koch, Ph.D.

Mentor: Dennis Thiele, Ph.D.

Thesis Defense: July 22, 1998

Essential transcription factor-DNA interactions for the transcriptional autoregulation of the Candida glabrata AMT1 gene

Rafael Perez-Ballestero, Ph.D.

Mentor: Michael Uhler, Ph.D.

Thesis Defense: May 14, 1998

Cloning and Characterization of Goldfish and Zebrafish Rich Proteins

Ramesh Rengan, M.D., Ph.D.

Mentor: Geneva Omann, Ph.D.

Thesis Defense: August 19, 1998

Signaling Actin Polymerization Responses in Hematopoietic Cells

Kristin Marie Rusche, Ph.D.

Mentor: Michael Marletta, Ph.D.

Thesis Defense: June 8, 1998

Studies of the nitric oxide synthase catalytic mechanism and structural requirement for 6(R)-tetrahydro-L-biopterin

James Chester Clemens, Ph.D.

Mentor: Jack E. Dixon, Ph.D.

Thesis Defense: September 3, 1999

Identification of a Novel Signaling Complex That Controls Axon Guidance in Drosophila

Sean Collins, M.D., Ph.D.

Mentor: Michael Uhler, Ph.D.

Thesis Defense: September 3, 1999

Compartmentalization of the Cyclic Nucleotide-Dependent Protein Kinases and Their Substrates

Wendolyn R. Davis, Ph.D.

Mentor: James Peliska, Ph.D.

Thesis Defense: October 8, 1999

“Mechanistic Characterization of New Inhibitors of DNA Strand Transfer Reactions Catalyzed By HIV-1 Reverse Transcriptase and Nucleocapsid Protein

John C. Kash, Ph.D.

Mentor: Jairam K.M. Menon, Ph.D.

Thesis Defense: March 24, 1999

Post-transcriptional control of lutropin/choriogonadotropin receptor in the ovary: identification and characterization of a receptor-specific mRNA binding protein

Seong J. Noh, M.D., Ph.D.

Mentor: Kun-Liang Guan, Ph.D.

Thesis Defense: May 12, 1999

Structure Function Analysis of P18 and the Role of KSR in Muscle Differentiation(MSTP)

Mariliz Ortiz-Maldonado, Ph.D.

Mentors: Vincent Massey, Ph.D.; Dave Ballou, Ph.D.

Thesis Defense: November 11, 1999

Insights on the Mechanism of Pseudomonas aeruginosa P-Hydroxybenzoate hydroxylase from QSAR Studies Using 8-substituted Flavins

Witoon Tirasophon, Ph.D.

Mentor: Randal Kaufman, Ph.D.

Thesis Defense: September 8, 1999

Signal transduction from the endoplasmic reticulum to the nucleus in mammalian cells

Cole M. Zimmerman, Ph.D.

Mentor: Lawrence Mathews, Ph.D.

Thesis Defense: September 30, 1999

Inhibition of SMAD-mediated activin and TGFb signaling by calmodulin

Gregor Zimmermann, Ph.D.

Mentor: Ronald Taussig, Ph.D.

Thesis Defense: December 3, 1999

Characterization of the Regulatory Properties of Mammalian Adenylyl Cyclase

Xiaoli Zhan, Ph.D.

Mentor: Kun-Liang Guan, Ph.D.

Thesis Defense: March 24, 1999

Function and Regulation of Protein Tyrosine Phosphatases in S. cerevisiae Signal Transduction

Yunde Zhao, Ph.D.

Mentor: Michael Marletta, Ph.D.

Thesis Defense: June 4, 1999

Characterization of the nitric oxide sensing domain of soluble guanylate cyclase

2000s

Merrill Douglas Benson, II, Ph.D.

Mentor: Renny Franceschi, Ph.D.

Thesis Defense: January 26, 2000

Osteoblast-Specific Regulation of Bone Sialoprotein Gene Transcription

Faye Andrea Bradbury, Ph.D.

Mentor: Jairam K.M. Menon, Ph.D.

Thesis Defense: May 17, 2000

Post-translational Processing and Internalization of the Luteinizing Hormone/Human Chorionic Gonadotropin Receptor

Clara Choi, M.D., Ph.D.

Mentor: Michael Marletta, Ph.D.

Thesis Defense: June 1, 2000

Investigating the Heme Detoxification Pathway of the Malaria Parasite Plasmodium falciparum - A Key to Antiplasmodial Therapy Development

Kerry Fluhr, Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: February 8, 2000

Residues That Affect Activation and Deactivation of Cobalamin-dependent Methionine Synthase (MetH)

Mark T. Hilgers, PhD.

Mentor: Martha Ludwig, Ph.D.

Thesis Defense: November 17, 2000

The Structure of LUXS, a Bacterial Protein Implicated in Intercellular Signaling

Shanna McClennen, Ph.D.

Mentor: Audrey Seasholtz, Ph.D.

Thesis Defense: January 31, 2000

Regulation of Corticotropin-Releasing Hormone Binding Protein Gene Expression

Nicholas Santoro, PhD.

Mentor: Dennis Thiele, Ph.D.

Thesis Defense: June 7, 2000

Distinct binding sites and signaling pathways regulate the Saccharomyces cerevisiae heat shock transcription factors

Bart Lee Staker, Ph.D.

Mentors: Mark Saper, PhD.; James Bardwell, Ph.D.

Thesis Defense: August 2, 2000

X-ray Crystallographic Studies of Three Nucleic Acid Binding Proteins

Lauren Stegman, M.D., Ph.D.

Mentor: Brian Ross, Ph.D.

Thesis Defense: September 18, 2000

Ph.D./M.D. conferred April 26, 2002

Magnetic Resonance-Based Markers of Treatment Response and Transgene Expression for Use in Brain Tumor Gene Therapy

Scott James Stewart, Ph.D.

Mentor: Kun-Liang Guan, Ph.D.

Thesis Defense: 2000

Regulation of Ras/Mitogen-Activated Protein (MAP) Kinase Signaling Pathways in Mammalian Cells

William A. Ziehler, PhD.

Mentor: David Engelke, Ph.D.

Thesis Defense: March 23, 2000

Biochemical and Genetic Analyses of the Structure and Function of the Ribonucleoprotein Enzyme, RNase P

Michelle Steinhilb, Ph.D.

Mentors: James Gaut, Ph.D.; Dennis Thiele, Ph.D.

Thesis Defense: December 17, 2001

Cellular Trafficking and Metabolism of the Alzheimer’s Disease Amyloid Precursor Protein (APP) in the Secretory and Endocytic Pathways

John Stansberry, Ph.D.

Mentor: Michael Uhler, Ph.D.

Thesis Defense: September 11, 2001

Biochemical and Functional Analysis of cGMP-Depedent Protein Kinases From C. elegans

Diane Hall, M.D., Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: March 21, 2001

Mapping the Interactions Between Flavodoxin and its Physiological Partners, Flavodoxin Reductase and Cobalamin-Dependent Methionine Synthase

Craig L. Smith, Ph.D.

Mentor: Mark Saper, Ph.D.

Thesis Defense: February 12, 2001

The Crystal Structure of the Amino-Terminal Domain of the YOPH From Yersinia pseudotuberculosis

Claudia Figueroa, Ph.D.

Mentor: Anne Vojtek, Ph.D.

Thesis Defense: December 15, 2002

Regulation of Ras Trafficking and Ras Signaling

Stacey M. Arnold, Ph.D.

Mentor: Randal Kaufman, Ph.D.

Thesis Defense: September 16, 2002

Cloning and Characterization of Human UDP-Glc:Glycoprotein Glucosyltransferase Homologues

Westley A. Sherman, Ph.D.

Mentor: Ari Gafni, Ph.D.

Thesis Defense: August 6, 2002

Slow Protein Folding Processes: Amyloid Kinetics, Phosphorescence Quenching, And the PAI-1 Conversion to Latency

Vladimir Ramirez-Carrozzi, Ph.D.

Mentor: Tom Kerppola, Ph.D.

Thesis Defense: August 1, 2002

Structural Basis and Functional Significance of Oriented FOS-JUN Heterodimer Binding

Joel Clement, Ph.D.

Mentor: Claudia Kent, Ph.D.

Thesis Defense: July 16, 2002

Identification of a Novel CTP:Phosphocholine Cytidylyltransferase-a Isoform

Chatchawan Srisawat, Ph.D.

Mentor: David Engelke, Ph.D.

Thesis Defense: June 11, 2002

The Study of Nuclear Ribonuclease P In S. cerevisiae Using Novel RNA Affinity Tags

Stephen Juris, Ph.D.

Mentor: Jack E. Dixon, Ph.D.

Thesis Defense: June 7, 2002

Analysis of the Function of the Yersinia Protein Kinase YPKA and Its Role in Bacterial Pathogenesis

Travis Tani, Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: April 8, 2002

Transitions Between The Gut and The Gutter: A Global Examination of the Regulon Controlled by the Leucine Responsive Regulatory Protein (LRP) in Escherichia coli

Timothy A. Blauwkamp, Ph.D.

Mentor: Alex Ninfa, Ph.D.

Thesis Defense: January 24, 2003

Principles of Signal Transduction and Gene Circuit Design Governing Nitrogen Assimilation in Escherichia coli

Heidi Campbell, Ph.D.

Mentor:Claudia Kent, Ph.D.

Thesis Defense: March 20, 2003

Enzymatic and Structural Characterization of Choline Kinase and CTP:Phosphocholine Cytidylyltransferase from Streptococcus pneumoniae

Seonok Lee (Muecke), Ph.D.

Mentor:Benjamin Margolis, Ph.D.

Thesis Defense: September 25, 2003

Discs Large and mLin-2/CASK: Evolutionarily Conserved Modulators of Epithelial Cell Polarity and Synaptic Junctions

Chuan Yin Liu, Ph.D.

Mentor: Randal Kaufman, Ph.D.

Thesis Defense: January 20, 2003

Structure and Function of the Stress Sensing Domain of IRE1 and PERK in the Unfolded Protein Response

Utpal Munshi, Ph.D.

Mentor: Jairam K.M. Menon, Ph.D.

Thesis Defense: November 12, 2003

Activation and Internalization of the Luteinizing Hormone/Human Chorionic Gonadotropin Receptor

Augen Pioszak, Ph.D.

Mentor: Alex Ninfa, Ph.D.

Thesis Defense: June 6, 2003

Mechanism of Signal Transduction Through the Escherichia coli Two-Component System Transmitter Protein NRII (NTRB)

Michael Roh, M.D., Ph.D.

Mentor: Benjamin Margolis, Ph.D.

Thesis Defense: April 1, 2003

The Role of the Crumbs Complex in Mammalian Epithelial Polarity

Xiaohua Shen, Ph.D.

Mentor: Randal Kaufman, Ph.D.

Thesis Defense: April 1, 2003

Unfolding the Unfolded Protein Response: Turn to the Worm!

Feng Shao, Ph.D.

Mentor: Jack E. Dixon, Ph.D.

Thesis Defense: March 19, 2003

Identification of a Novel Family Cysteine Proteases and Their Functions in Bacterial Pathogenesis

Haris G. Vikis, Ph.D.

Mentor: Kun-Liang Guan, Ph.D.

Thesis Defense: March 4, 2003

Signaling Mechanisms of the Semaphorin Receptor Plexin-B1

Dong Xu, Ph.D.

Mentors: Vincent Massey, Ph.D.; Dave Ballou, Ph.D.

Thesis Defense: May 27, 2003

Studies of the Reaction Mechanism of Phenol Hydroxylase: Site-Directed Mutagenesis and 6-Azido-FAD

Hao Zhou, Ph.D.

Mentor: Dennis Thiele, Ph.D.

Thesis Defense: December 10, 2003

Identification of Novel Copper Transport Genes in Eukaryotic Cells

Jennifer Blanchette, Ph.D.

Mentor: Robert S. Fuller, Ph.D.

Thesis Defense: August 12, 2004

Characterization of Saccharomyces cerevisiae trans Golgi network protein trafficking events using cell-free systems

Eddy Brace, Ph.D.

Mentor: Robert S. Fuller, Ph.D.

Thesis Defense: December 14, 2004

Role of Soi3p in Localization of the Processing Protease Kex2p to the trans-golgi Network through Assembly of Vacuolar ATPase

Jeremy J. Day-Storms, Ph.D.

Mentor: Carol Fierke, Ph.D.

Thesis Defense: August 16, 2004

RNA-Protein Interactions in Prokaryotic and Eukaryotic Ribonuclease P

Elise Hondorp (Manning), Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: October 11, 2004

Oxidative Stress Inactivates Cobalamin-Independent Methionine Synthase in Escherichia coli

David M. Karnak, Ph.D.

Mentor: Benjamin Margolis, Ph.D.

Thesis Defense: May 20, 2004

Biochemical and Structural Studies of the Lin-2 and 7 (L27) Dimerization Domain: Linking Proteins Important in Cell Polarity

Huira Kopera (Chong), Ph.D.

Mentor: Kun-Liang Guan, Ph.D.

Thesis Defense: September 27, 2004

Oxidative Stress Inactivates Cobalamin-Independent Methionine Synthase in Escherichia coli

Jennifer Aurandt, Ph.D.

Mentor: Kun-Liang Guan, Ph.D.

Thesis Defense: June 10, 2005

Signaling Mechanisms of Plexin-B1: A receptor for Semaphorin 4D

Scott Berger, Ph.D.

Mentor: Richard Miller, Ph.D.

Thesis Defense: October 28, 2005

Enhanced T Lymphocyte Function in Young and Old Mice Through Changes in Surface Glycoproteins

Stephen P.L. Cary, Ph.D.

Mentor: Michael Marletta, Ph.D.

Thesis Defense: July 6, 2005

Tonic and Acute Nitric Oxide Signaling Through Soluble Guanylate Cyclase: Roles of Non-Heme NO, ATP, and Globins

Peter Clapp, Ph.D.

Mentor: Richard Neubig, Ph.D.

Thesis Defense: August 12, 2005

Identification and functional characterization of two novel a1 adrenergic receptor-interacting proteins

Katherine Hicks, Ph.D.

Mentor: Carol Fierke, Ph.D.

Thesis Defense: October 13, 2005

Protein Farnesyltransferase: Investigation of Peptide Specificity Determinants and Identification of Novel Substrates

Jeeyong Lee, Ph.D.

Mentor: Kun-Liang Guan, Ph.D.

Thesis Defense: March 25, 2005

Netrin-mediated signal transduction in Caenorhabditis elegans

Anthony Ludlam, Ph.D.

Mentor: Zhaohui Xu, Ph.D.

Thesis Defense: October 14, 2005

Structure and Function of the Bacterial Ribosome-Bound Chaperone Trigger Factor

Robert Pejchal, Ph.D.

Mentor: Martha Ludwig, Ph.D.

Thesis Defense: February 17, 2005

Structural Studies of Methylenetetrahydrofolate Reductase and Cobalamin-Independent Methionine Synthase: Back-to-Back Enzymes in One-Carbon Metabolism

Mattabhorn Phimphilai, Ph.D.

Mentor: Renny Franceschi, Ph.D.

Thesis Defense: December 9, 2005

Cooperative Interactions Between Bone Morphogenetic Proteins and the RUNX2 Transcription Factor in Osteoblast Differentiation

Rebecca Taurog, Ph.D.

Mentor: Rowena Matthews, Ph.D.

Thesis Defense: November 30, 2005

Substrate Binding and Activation in Cobalamin-Independent Methionine Synthase

Shaohua Xiao, Ph.D.

Mentor: David Engelke, Ph.D.

Thesis Defense: August 15, 2005

Functional Characterization of the Eukaryotic-specific Conserved Features of Nuclear RNase P in the Yeast Saccharomyces cerevisiae

Mohamed Abazeed, M.D., Ph.D.

Mentor: Robert S.Fuller, Ph.D.

Thesis Defense: January 12, 2006

Analysis of Clathrin Vesicle Transport from the trans Golgi Network to the Late Endosome/Prevacuolar Compartment

Andrew Andrews, Ph.D.

Mentor: Carol Fierke, Ph.D.

Thesis Defense: May 24, 2006

Function of Inner-sphere metal ions in RNase P catalysis

Adam Avery, Ph.D.

Mentor: Anne Vojtek, Ph.D.

Thesis Defense: July 26, 2006

Elucidation of UNC-51-like kinase signaling pathways

Christine Clouser, Ph.D.

Mentor: Jairam K.M. Menon, Ph.D.

Thesis Defense: February 6, 2006

Processing and Trafficking of the Luteinizing Hormone Receptor

Kuei Lee, Ph.D.

Mentor: Brian Ross, Ph.D.

Thesis Defense: February 22, 2006

Molecular Imaging Biomarkers in the Evaluation of Experimental Therapeutics

KunYoo Shin, Ph.D.

Mentor: Benjamin Margolis, Ph.D.

Thesis Defense: March 23, 2006

The Role of PATJ in Mammalian Epithelial Cell Polarity and Tight Junction Formation

Julie Coppola (Williams), Ph.D.

Mentor: Brian Ross, Ph.D.

Thesis Defense: February 2, 2007

Cell-based Assays for Proteolytic Activity and their Application in Drug Discovery

Daniel Coughlin, Ph.D.

Mentor: David Engelke, Ph.D.

Thesis Defense: August 1, 2007

Expanding the set of known substrates of nuclear RNase P

Blake Fausett, M.D., Ph.D.

Mentor: Daniel Goldman, Ph.D.

Thesis Defense: June 7, 2007

Mechanisms of Retina Regeneration in Zebrafish

Rebecca Haeusler, Ph.D.

Mentor: David Engelke, Ph.D.

Thesis Defense: February 2, 2007

tRNA Genes as Organizers of Genetic Information

Chung-Han Lee, Ph.D.

Mentor: KunLiang Guan, Ph.D.

Thesis Defense: June 4, 2007

Glucose Starvation Induces Apoptosis of TSC-/- cells in a p53-dependent Manner

Brian Moore, Ph.D.

Mentor: Zhaohui Xu, Ph.D.

Thesis Defense: July 16, 2007

Structures of Exocyst Subunit Exo70 from Yeast and Mouse

June Pais, Ph.D.

Mentor: Carol Fierke, Ph.D.

Thesis Defense: September 20, 2007

Mechanism of Catalysis and Inhibition of Mammalian Protein Farnesyltransferase

Narinporn Pattaramanon, Ph.D.

Mentor: Ari Gafni, Ph.D.

Thesis Defense: February 2, 2007

Conformational analysis of Heat Shock Factor 1 C-terminal domain

Lei Wang, Ph.D.

Mentor: Jairam K.M. Menon

Thesis Defense: December 18, 2007

Studies on the Post-Transcriptional Regulation of Luteinizing Hormone Receptor Expression in the Ovary

Qian Wang, Ph.D.

Mentor: Benjamin Margolis, Ph.D.

Thesis Defense: July 3, 2007

THE ROLE OF PALS1 IN MAMMALIAN EPITHELIAL POLARITY

Jun Wu, Ph.D.

Mentor: Randal Kaufman, Ph.D.

Thesis Defense: August 27, 2007

Roles of the Unfolded Protein Response in Cultured Cells and Transgenic Murine Models

Qian Yang, Ph.D.

Mentor: Kun-Liang Guan, Ph.D.

Thesis Defense: June 16, 2007

mTOR Regulation

Lance Rider, Ph.D.

Mentor: Bruce Palfey

Thesis Defense: November 5, 2008

Flavoenzymes involved in pyrimidine oxidation and reduction

Pamela Wong, Ph.D.

Mentor: Ari Gafni, Ph.D.

Thesis Defense: December 12, 2008

Characterization of Amyloid-β interactions at the membrane interface: implications for pathogenesis

Junyu Xiao, Ph.D.

Mentor: Zhaohui Xu, Ph.D.

Thesis Defense: December 12, 2008

Structural basis of Vps4 function and regulation in the multivesicular body pathway

Jared Chrispell, Ph.D.

Mentor: Debra A. Thompson, Ph.D.

Thesis Defense: November 17, 2009

Characterization of RPE65 and RDH12, Two Enzymes Associated With Retinal Dystrophy and Retinoid Processing

Rebecca Fagan, Ph.D.

Mentor: Bruce Palfey, Ph.D.

Thesis Defense: February 20, 2009

The Differences are in the Details: The Mechanism of Flavin Reduction in Class 1A and Class 2 Dihydroorotate Dehydrogenases

Edgar Lee, Ph.D.

Mentor: Ari Gafni, Ph.D.

Thesis Defense: July 15, 2009

Pancreatic Islet Amyloid Polypeptide Membrane Binding and Permeabilization

Tushar Menon, Ph.D.

Mentor: Daniel A. Bochar, Ph.D.

Thesis Defense: December 1, 2009

Regulation of Androgen-Responsive Transcription by the Chromatin Remodeling Enzyme

Feng Wang, Ph.D.

Mentor: Ming Lei, Ph.D.

Thesis Defense: November 24, 2009

Structural Analyses of Telomere Associated Proteins

Abigail E. Wolfe, Ph.D.

Mentor: Patrick J. O'Brien, Ph.D.

Thesis Defense: December 11, 2009

Kinetic Mechanism for Binding and Flipping of Damaged Bases by Alkyladenine DNA Glycosylase

Bin Zhao, Ph.D.

Mentor: Kun-Liang Guan, Ph.D.

Thesis Defense: February 12, 2009

Inactivation of YAP-TEAD by the Hippo Pathway is Involved in Growth Control and Cancer

2010s

Stacie L. Bulfer, Ph.D.

Mentor: Raymond C. Trievel, Ph.D.

Thesis Defense: February 5, 2010

Structure, Mechanism and Regulation of Homocitrate Synthase

Heather Brianna Claxton, Ph.D.

Mentor: Janet L. Smith, Ph.D.

Thesis Defense: November 22, 2010

Investigation into the Activity and Specificity of the Thioesterase II, Ketoreductase and Dehydratase Domains of Multiple Polyketide Synthases

Samuel G. Gattis, Ph.D.

Mentor: Carol A. Fierke, Ph.D.

Thesis Defense: April 19, 2010

Mechanism and metal specificity of Zn-dependent deacetylases

Michael C. Marvin, Ph.D.

Mentor: David R. Engelke, Ph.D.

Thesis Defense: December 10, 2010

Identification and Characterization of Expanded RNA Binding Abilities and Cellular Roles for Nuclear RNase P

Jay N. Pieczynski, Ph.D.

Mentor: Benjamin L. Margolis, M.D.

Thesis Defense: August 6, 2010

Regulation of Apical Polarity Complexes

Zhonghua Yan, Ph.D.

Mentor: Ruma Banerjee, Ph.D.

Thesis Defense: October 21, 2010

Thiol-mediated Redox Modulation of the Adaptive Immune Response

Li Yi, Ph.D.

Mentor: Stephen W. Ragsdale, Ph.D.

Thesis Defense: April 28, 2010

Characterization of the Redox Switches in Human Heme Oxygenase-2 and a Human Heme-Responsive Potassium Channel

Veronica E. Burns, Ph.D.

Mentor: Tom Kerppola, Ph.D.

Thesis Defense: July 19, 2011

Structural Basis and Functional Consequences of Alternative ATF2-Jun Heterodimer Orientations at the Interferon-Beta Enhancer

Valentin F. Cracan, Ph.D.

Mentor: Ruma V. Banerjee, Ph.D.

Thesis Defense: December 12, 2011

Structure, Function and Metabolic Roles of IcmF-a Fusion Between the Radical B12 Enzyme and its G-protein Chaperone

Ryan T. Evans, Ph.D.

Mentor: Audrey Seasholtz, Ph.D.

Thesis Defense: April 26, 2011

Splicing and Multiple Binding Proteins in the Corticotropin-Releasing Hormone Stress System

Nirupama Gupta, Ph.D.

Mentor: Stephen W. Ragsdale, Ph.D.

Thesis Defense: August 15, 2011

Thiol-based redox modulation of transcriptional regulators; CprK and Rev-erbβ

Corissa L. Lamphear, Ph.D.

Mentor: Carol A. Fierke, Ph.D.

Thesis Defense: December 8, 2011

Molecular Recognition of Substrates by Protein Farnesyltransferase and Geranylgeranyltransferanse-I

Li Li, Ph.D.

Mentor: Kun-Liang Guan, Ph.D.

Thesis Defense: February 14, 2011

Upstream Components of mTORC1

Cherisse Rae Loucks, Ph.D.

Mentor: Georgios Skiniotis, Ph.D.

Thesis Defense: April 25, 2011

Molecular Architecture of a 40S Ribosomal Subunit Maturation Intermediate

Dave A Pai, Ph.D.

Mentor: David R. Engelke, Ph.D.

Thesis Defense: December 16, 2011

Spatial coordination of tRNA genes

Elizabeth A. Pierce, Ph.D.

Mentor: Stephen W. Ragsdale, Ph.D.

Thesis Defense: August 31, 2011

Identification and Characterization of Oxalate Oxidoreductase, a Novel Thiamine Pyrophosphate-dependent Enzyme That Enables Anaerobic Growth on Oxalate

Ashley A. Reinke, Ph.D.

Mentor: Jason E. Gestwicki, Ph.D.

Thesis Defense: February 7, 2011

Conformation-specific chemical probes for amyloid-β

Heather M. Dickson, Ph.D.

Mentor: Anne Vojtek, Ph.D.

Thesis Defense: April 25, 2012

Insights into the molecular mechanism of axon outgrowth by myelin associated inhibitors

Jennifer Gehret McCarthy, Ph.D.

Mentor: Janet Smith, Ph.D.

Thesis Defense: October 15, 2012

Production of Terminal Alkenes in Natural Product Biosynthesis: Structural Studies of Sulfotransferase and Thioesterase Didomains

Justin R. Hassler, Ph.D.

Mentor: Randal J. Kaufman, Ph.D.

Thesis Defense: October 18, 2012

Dissecting the biological function of the Unfolded Protein Response sensor Ire1α through gene deletion

Swathi Krishnan, Ph.D.

Mentor: Ray Trievel, Ph.D.

Thesis Defense: November 2, 2012

Structural and Biochemical Insights into Methylation Site and State Specificity of JMJD2 Lysine Demethylases

Donald D. Raymond, Ph.D.

Mentor: Janet L. Smith, Ph.D.

Thesis Defense: August 13, 2012

Structural Studies of Genome Packaging in Phleboviruses

Shameka J. Shelby, Ph.D.

Mentor: Debra A. Thompson, Ph.D.

Thesis Defense: August 14, 2012

MERTK-mediated Signaling in the Retinal Pigment Epithelium: Insights into the Mechanism of RPE Phagocytosis

Stewart Siyan Cao, M.D., Ph.D.

Mentor: Randal J. Kaufman, Ph.D.

Thesis Defense: March 4, 2013

Endoplasmic Reticulum Stress in Intestinal Epithelial Cells and Inflammatory Bowel Disease

Sean P. Ferris, M.D., Ph.D.

Mentors: Randal J. Kaufman, Ph.D. and Peter Arvan, M.D., Ph.D.

Thesis Defense: March 28, 2013

UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum

Michael W. Lofgren, Ph.D.

Mentor: Ruma Banerjee, Ph.D.

Thesis Defense: June 25, 2013

Auxiliary Proteins and Allosteric Control of the Mitochondrial Branch of B12 Trafficking, Assembly and Reactivity

Liliya V. Mancour, Ph.D.

Mentor: Georgios Skiniotis, Ph.D.

Thesis Defense: April 3, 2013

Structural Dynamics of Transmembrane Signaling Complexes by Negative Stain Electron Microscopy

Claudia A. McDonald, Ph.D.

Mentor: Bruce Palfey, Ph.D.

Thesis Defense: March 28, 2013

The Enzymology of the Monooxygenase Domain of MICAL-2

Joseph A. Micucci, Ph.D.

Mentors: Donna Martin, M.D., Daniel Bochar, Ph.D.

Thesis Defense: October 30, 2013

The role of ATP-dependent chromatin remodeling enzyme CHD7 in the development and maintenance of murine neural stem cells

Jamie L. Van Etten, Ph.D.

Mentor: Aaron Goldstrohm, Ph.D.

Thesis Defense: September 6, 2013

Regulatory Mechanisms and RNA Targets of Human Pumilio Proteins

Gerwin H. Westfield, Ph.D.

Mentor: Georgios Skiniotis, Ph.D.

Thesis Defense: August 29, 2013

Molecular Electron Microscopy of Signaling Protein Complexes

Brittany M. Bowman, Ph.D.

Mentor: Brian D. Ross, Ph.D.

Thesis Defense: November 20, 2014

FADD and its Phosphorylation Mediate Mitogenic Signaling in Mutant Kras Tumors

Jenna M. Hendershot, Ph.D.

Mentor: Patrick J. O'Brien, Ph.D.

Thesis Defense: September 8, 2014

Mechanism of Nucleotide Flipping by Human Alkyladenine DNA Glycosylase

Curtis R. Powell, Ph.D.

Mentor: Daniel J. Goldman, Ph.D.

Thesis Defense: April 17, 2014

The Role of Apobec2 During Zebrafish Retina and Optic Nerve Regeneration

Amber M. Smith, Ph.D.

Mentor: Janet L. Smith, Ph.D.

Thesis Defense: October 27, 2014

Structural Investigation of the Mechanism and Regulation of the PLPS

Mark R. Taylor, Ph.D.

Mentor: Patrick J. O'Brien, Ph.D.

Thesis Defense: May 7, 2014

The Role of Divalent Metal Ions in Enzymatic DNA Ligation

Cody Vild, Ph.D.

Mentor: Zhaohui Xu, Ph.D.

Thesis Defense: August 18, 2014

Structural analysis of ESCRT-III dependent regulation of LIP5 reveals divergent mechanism of VPS4 regulation

Noah A. Wolfson, Ph.D.

Mentor: Carol A. Fierke, Ph.D.

Thesis Defense: May 12, 2014

The Determination of HDAC8 substrate specificity

Manila Hada, Ph.D.

Mentor: Roland P. Kwok, Ph.D.

Thesis Defense: August 31, 2015

Regulation of Ku70 Bax Complex in Cells

Michael J. Howard, Ph.D.

Mentor: Carol A. Fierke, Ph.D.

Thesis Defense: August 27, 2015

Structure and Function of Protein-only RNase P

Jennifer N. Rauch, Ph.D.

Mentor: Jason E. Gestwicki, Ph.D.

Thesis Defense: March 19, 2015

Regulation of Human Hsp70 by its Nucleotide Exchange Factors (NEFs)

Erin Taylor, Ph.D.

Mentor: Patrick J. O'Brien, Ph.D.

Thesis Defense: August 31, 2015

Mechanistic studies of alkylation repair DNA glycosylases

Chase A. Weidmann, Ph.D.

Mentor: Aaron C. Goldstrohm, Ph.D.

Thesis Defense: April 27, 2015

Mechanisms of mRNA regulation by Pumilio and Nanos

Bryan Dunyak, Ph.D.

Mentor: Jason E. Gestwicki, Ph.D.

Thesis Defense: September 13, 2016

Peptidyl-Proline Isomerases: Promising Targets for Natural Product-Inspired Therapeutics

Benjamin Ellington, Ph.D., J.D.

Mentor: Neil Marsh, Ph.D.

Thesis Defense: January 15, 2016

Probing the Mechanisms of Aldehyde Decarbonylation using Radical Clock Substrate Analogues

Elia Wright Hefner, Ph.D.

Mentor: Carol A. Fierke, Ph.D.

Thesis Defense: July 18, 2016

Elucidating the Potential Role of Protein Prenylation in Bacterial Infection

Bradley Klemm, Ph.D.

Mentor: Carol A. Fierke, Ph.D.

Thesis Defense: December 5, 2016

Substrate Recognition by Protein-only Ribonuclease Ps

Andrew Sikkema, Ph.D.

Mentor: Janet L. Smith, Ph.D.

Thesis Defense: December 12, 2016

Structural and Biochemical Studies of the Initiation Steps in Three Natural Product Biosynthetic Pathways

Qingyun Dan, Ph.D.

Mentor: Janet L. Smith, Ph.D.

Thesis Defense: January 9, 2017

Structural and Biochemical Characterization of the Early Steps in Fungal Indole Alkaloid Biosynthesis

Robert Fick, Ph.D.

Mentor: Raymond C. Trievel, Ph.D.

Thesis Defense: December 7, 2017

Characterization of Methyltransferase Carbon-Oxygen Hydrogen Bonding and Sulfur-Oxygen Chalcogen Bonding with the Sulfonium of S-adenosyl-L-methionine

Nicole Motl, Ph.D.

Mentor: Ruma Banerjee, Ph.D.

Thesis Defense: May 15, 2017

Structural Enzymology of Sulfide Oxidation by Persulfide Dioxygenase and Rhodanese

Samuel Slocum, Ph.D.

Mentors: Janet L. Smith, Ph.D.; David Sherman, Ph.D.

Thesis Defense: November 3, 2017

Biochemical studies of polyketide beta-branching and polyketide synthase module architecture

Eric Tse, Ph.D.

Mentor: Daniel Southworth, Ph.D.

Thesis Defense: November 30, 2017

Quality control mechanisms of molecular chaperones in the folding and degradation of client proteins

Wallace Chan, Ph.D.

Mentor: Yang Zhang, Ph.D.

Thesis Defense: September 12, 2018

Development and Application of Virtual Screening Methods for G Protein-Coupled Receptors

Greg Dodge, Ph.D.

Mentor: Janet L. Smith, Ph.D.

Thesis Defense: June 6, 2018

Structural and Biochemical Studies of Polyketide Synthase and Fatty Acid Synthase Dehydratase

Grace Kroner, Ph.D.

Mentor: Peter Freddolino, Ph.D.

Thesis Defense: April 13, 2018

Regulation of E. coli genome architecture and transcription in response to changing nutrient levels

Meredith Skiba, Ph.D.

Mentor: Janet L. Smith, Ph.D.

Thesis Defense: August 30, 2018

Structural and Biochemical Investigation of Methylation and Elucidation of t-Butyl Formation in Polyketide Biosynthesis

Elizabeth Abshire, Ph.D.

Mentors: Raymond C. Trievel, Ph.D.; Aaron C. Goldstrohm, Ph.D.

Thesis Defense: April 3, 2019

Structural and Functional Characterization of the Human Enzyme Nocturnin

René Arvola, Ph.D.

Mentor: Aaron C. Goldstrohm, Ph.D.

Thesis Defense: April 24, 2019

Messenger RNA control by Pumilio

Jennifer Bohn, Ph.D.

Mentor: Janet L. Smith, Ph.D.

Thesis Defense: July 30, 2019

APOBEC3H Antiviral Mechanisms Driven by Protein-Nucleic Acid Interactions: Structure and Function

Claire Cato, Ph.D.

Mentors: John Tesmer, Ph.D.; Janet L. Smith, Ph.D.

Thesis Defense: April 22, 2019

Structural and Biochemical Analysis of G Protein-Coupled Receptor Kinase Activation and Small Molecule Inhibitor Specificity

Tom Jurkiw, Ph.D.

Mentor: Patrick J. O'Brien, Ph.D.

Thesis Defense: January 17, 2019

Mechanism and Specificity of Human DNA Ligase I

Justin McNally, Ph.D.

Mentor: Patrick J. O'Brien, Ph.D.

Thesis Defense: January 16, 2019

Kinetic Analysis of Human DNA Ligase III

Michael Wolfe, Ph.D.

Mentor: Peter Freddolino, Ph.D.

Thesis Defense: July 15, 2019

Regulation of Gene Expression Through Nucleic Acid Binding Proteins: New Paradigms, Perspectives, and Tools

2020s

We're glad you stopped by!

1920s

Daniel A. McGinty, Ph.D.

Helen Updegraff, Ph.D.

Seiichi Izume, Ph.D.

Margaret W. Johnston, Ph.D

George T. Lewis, Ph.D.

Olive May Searle, Ph.D.

Genevieve Sterns, Ph.D.

Frank Hartman Wiley, Ph.D.

Robert Hugh Wilson, Ph.D.

1930s

Joseph P. Chandler, Ph.D.

Howard D. Lightbody, Ph.D.

Abraham White, Ph.D.

Mabel Marie Miller, Ph.D.

Robert L Grant, Ph.D.

S. Allan Lough, Ph.D.

Alfred K. Silberman, Ph.D.

Victor Julius Tulane, Ph.D.

Robert Wallace Virtue, Ph.D.

William C. Lee, PhD.

Adelaida M. Bendana (Brown), Ph.D.

Norbert Harper Fell, Ph.D.

Florence Roy White, Ph.D.

Lila Miller, Ph.D.

Evangeline T. Papageorge, Ph.D.

Svend Pederson, Ph.D.

Barker Hastings Brown, Ph.D.

Ross Aiken Gortner, Jr., Ph.D.

Evelyn V. Heard, Ph.D.

Joseph Isaac Routh, Ph.D.

Lawrence Louis, Ph.D.

Walter David Block, Ph.D.

Pong Cheh Jen, Ph.D.

Gertrude Rodney, Ph.D.

Sidney F. Velick, Ph.D.

Carleton R. Treadwell, Ph.D.

Bruno Vassel, Ph.D.

Julius Schultz, Ph.D.

1940s

Lynn De Forrest Abbott Jr., Ph.D.

Frank Raymond Blood, Ph.D.

Joseph Henry Gast, Ph.D.

Margaret E. Nalder, Ph.D.

Sam Allen Singal, Ph.D.

William J. Darby Jr., Ph.D.

Andrew A. Ormsby, Ph.D.

Tersti P. Salo, Ph.D.

Marjorie J. Groothuis (Horning), Ph.D.

Stanley Levey, Ph.D.

Yen Hoong Loo, Ph.D.

Frances A. Schofield, Ph.D.

Bernard Shacter, Ph.D.

Eugene Roberts, Ph.D.

Max Eli Chilcote, Ph.D.

John Zim Hearon, Jr., Ph.D.

Robert F. Witter, Ph.D.

Oliver H. Buchanan, Ph.D.

Max Schlamowitz, Ph.D.

Hui-Lan Yeh, Ph.D.

Dominic D. Dziewiatkowski, Ph.D.

William J. Wingo, Ph.D.

Stanley Cohen, Ph.D.

1950s

Gordon C. Mills, Ph.D.

D. Maxwell Teague, Ph.D.

Evelyn Pease Tyner, Ph.D.

George S. Wells, Ph.D.

Baldridge, Robert C., Ph.D.

Adrian Hainline, Jr., Ph.D.

Raymond E. Knauff, Ph.D.

Leo Lutwak, Ph.D.

Arthur Robert Schulert, Ph.D.

Herbert Weinfeld, Ph.D.

Chung Wu, Ph.D.

John Philip Davison, Ph.D.

Otto Wilhelm Neuhaus, Ph.D.

Laura W. Rahm (Hawkins), Ph.D.

Helen L. C. Wu, Ph.D.