Phyllis I. Hanson, M.D., Ph.D.

Minor J. Coon Collegiate Professor, Biological Chemistry
Chair, Biological Chemistry
Ofc: 5301C MSRB III
Lab: 5315 MSRB III
1150 W. Medical Center Drive
Ann Arbor, MI  48109-5606
 
(734) 647-6180 Ofc / (734) 936-2726 Lab

Biography

Dr. Hanson earned a B.A. in Molecular Biophysics and Biochemistry from Yale University, and Ph.D. and M.D. degrees from the Stanford University School of Medicine studying Ca2+/calmodulin dependent protein kinase II. She then completed postdoctoral work at Yale in membrane trafficking before joining the Washington University faculty, where she rose from assistant professor in 1997 to the Gerty T. Cori Professorship in the Department of Cell Biology and Physiology in 2016. She moved to the University of Michigan as the Minor J. Coon Professor and Chair in 2018.

Dr. Hanson is an associate editor of the Journal of Biological Chemistry and a member of the American Society of Cell Biology, the American Society for Biochemistry and Molecular Biology, and the American Association for the Advancement of Science. She recently served as chair of the National Institutes of Health (NIH) Membrane Biology and Protein Processing Study Section, and earlier as chair of the NIH Synapses, Cytoskeleton and Trafficking Study Section. Among her honors, she was a W.M. Keck Foundation Distinguished Young Scholar in Medical Research and also received Searle, McKnight, and Sloan scholar awards. She will serve as vice chair and then chair of the Gordon Research Conference on Lysosomes and Endocytosis.

Areas of Interest

Dr. Hanson’s research focuses on understanding how proteins interact to regulate the structure and organization of cell membranes both inside and outside the cell, and has implications for understanding a wide range of diseases including among others neurodegenerative disorders such as Alzheimer’s disease and the debilitating movement disorder, dystonia. Specific areas of interest include protein-protein and protein-membrane interactions involved in membrane trafficking and organelle structure, with focus on ESCRTs, AAA+ ATPases and associated machinery.

Honors & Awards

     2016       AAAS Fellow, American Association for the Advancement of Science
     2016       Gerty T. Cori Professorship, Washington University School of Medicine
     1999       Distinguished Young Scholar in Medical Research, W.M. Keck Foundation
     1999       Searle Scholar Award
     1999       Sloan Research Fellowship
1998-2000   McKnight Scholar Award

Published Articles or Reviews

Recent Publications

A cell-based assay for CD63-containing extracellular vesicles.
Cashikar AG, Hanson PI.
PLoS One. 2019; 14: e0220007.

Mycobacterium tuberculosis Type VII Secretion System Effectors Differentially Impact the ESCRT Endomembrane Damage Response.
Mittal E, Skowyra ML, Uwase G, Tinaztepe E, Mehra A, Köster S, Hanson PI, Philips JA.
MBio. 2018; 9: e01765-18.

Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation.
Rimer JM, Lee J, Holley CL, Crowder RJ, Chen DL, Hanson PI, Ory DS, Schaffer JE.
J Biol Chem. 2018; 293: 13284-96.

Triggered recruitment of ESCRT machinery promotes endolysosomal repair.
Skowyra ML, Schlesinger PH, Naismith TV, Hanson PI.
Science. 2018; 360: eaar5078.

Effects of Inhibiting VPS4 Support a General Role for ESCRTs in Extracellular Vesicle Biogenesis.
Jackson CE, Scruggs BS, Schaffer JE, Hanson PI.
Biophys J. 2017; 113: 1342-52.

Torsins Are Essential Regulators of Cellular Lipid Metabolism.
Grillet M, Dominguez Gonzalez B, Sicart A, Pöttler M, Cascalho A, Billion K, Hernandez Diaz S, Swerts J, Naismith TV, Gounko NV, Verstreken P, Hanson PI, Goodchild RE.
Dev Cell. 2016; 38: 235-47.

Structure and membrane remodeling activity of ESCRT-III helical polymers.
McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A.
Science. 2015; 350: 1548-51.

For a list of publications from PubMed, click HERE