Rene' Arvola

Ph.D. Student
Mentor: Dr. Aaron Goldstrohm

Areas of Interest

Protein expression can be regulated by sequence-specific RNA-binding proteins, such as those of the Pumilio and FBF (PUF) family, via stimulation of decay and inhibition of translation. Pumilio (Pum) in Drosophila is a founding member of the PUF family, known for its role in establishing body pattern formation during embryogenesis via its repression of a key morphogen. Regulation of mRNAs by Pum is likely extensive, as it binds many hundreds of different mRNAs and controls processes such as neurological function, stem cell maintenance, and fertility. My project aims to determine the mechanisms of repression by the N-terminus of Pum, which is able to repress independently of its RNA binding domain when tethered to an mRNA

Presentations

20th Annual Meeting of the RNA Society, May 2015 (Madison, WI) Poster: "Pumilio represses mRNA expression through multiple mechamisms"

Rustbelt RNA Meeting, October 2014 (Pittsburgh, PA) Poster: “Dissecting the Mechanisms of Pumilio Mediated Repression”

University of Michigan Biological Chemistry Retreat, August 2014 (Kellogg Biological Station) Poster: “Elucidation of Pumilio N-terminal Repression Domains”

University of Michigan Biological Chemistry Retreat, August 2013 (Kellogg Biological Station) Poster: “Analysis of Pumilio N-terminal Repression Domains”

Rackham Summer Institute Poster, August 2013 (Ann Arbor, MI) Poster: “Analysis of Pumilio N-terminal Repression Domains”

Honors & Awards

Rackham Merit Fellowship (2013-present)

University of Michigan Pre-doctoral Genetics Training Program (2014-present)

NSF Graduate Research Fellowship (2015)

Rackham Travel Grant (2015)