Roland Kwok, Ph.D.

Associate Professor Emeritus, Obstetrics and Gynecology
Associate Professor Emeritus, Biological Chemistry

Biography

Professor Kwok received his B.Sc. degree from Chu Hai College in Hong Kong in 1982, his M.Sc. degree from the University of Saskatchewan in Canada in 1985, and his Ph.D. degree from the University of Pittsburgh in 1991. He received his post-doctoral training at the Oregon Health Sciences University in Portland, Oregon. He joined the University of Michigan faculty as an assistant professor in 1998, and was promoted to associate professor in 2006. He retired from active faculty status in 2022.

Professor Kwok’s research focused on how post-translational modifications, such as acetylation and phosphorylation, of factors involved in cell death pathways would determine cell death in cancer cells. He has over 40 peer-reviewed publications and his research helped reveal new targets for drugs in cancer treatment. His work was supported by the National Institutes of Health, the Leukemia and Lymphoma Society, and the American Cancer Society. He also served as a reviewer for various scientific journals and as a research grant reviewer for the Department of Defense for more than 15 years.

In addition to his research, Professor Kwok mentored numerous post-doctoral fellows, graduate students, and undergraduate students. Many of his mentees are now physicians and professors, developing their own contributions at various institutions across the U.S. Professor Kwok served as a member of many preliminary examination and dissertation committees. His latest service was a three-year term as a member of the Academic Performance Committee (APC) and the Advisory Board on Intercollegiate Athletics (ABIA).

Published Articles or Reviews

Recent Publications

Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions.
Liu M, Dexheimer T, Sui D, Hovde S, Deng X, Kwok R, Bochar DA, Kuo MH.
Sci Rep. 2020; 10: 16551.

Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death.
Liu M, Sui D, Dexheimer T, Hovde S, Deng X, Wang KW, Lin HL, Chien HT, Kweon HK, Kuo NS, Ayoub CA, Jimenez-Harrison D, Andrews PC, Kwok R, Bochar DA, Kuret J, Fortin J, Tsay YG, Kuo MH.
Mol Neurobiol. 2020; 57: 4704–19.

Cytosolic Ku70 regulates Bax-mediated cell death.
Hada M, Subramanian C, Andrews PC, Kwok RP.
Tumour Biol. 2016; 37: 13903–14.

Regulation of Ku70-Bax complex in cells.
Hada M, Kwok RP.
J Cell Death. 2014; 7: 11–13.

CREB-binding protein regulates Ku70 acetylation in response to ionization radiation in neuroblastoma.
Subramanian C, Hada M, Opipari AW Jr, Castle VP, Kwok RP.
Mol Cancer Res. 2013; 11: 173–81.

For a list of publications from Pubmed, click HERE