Ryan Baldridge
Assistant Professor of Biological Chemistry
[email protected]

Available to mentor

Ryan Baldridge
Assistant Professor
  • About
  • Links
  • Qualifications
  • Research Overview
  • Recent Publications
  • About

    I grew up in Northern Kentucky and attended Northern Kentucky University as an undergraduate student. During this time, I worked at the Wood Hudson Cancer Research Laboratory with Dr. Bonnie Richmond and later in the lab of Dr. Patrick Schultheis at Northern Kentucky University. I graduated with two BS degrees in 2007 (in Biological Sciences and Chemistry). My PhD training was with Todd Graham at Vanderbilt University where I worked on mechanics of phospholipid "flippases", graduating in 2013. I completed my postdoctoral training with Tom Rapoport at Harvard Medical School in 2017, working on mechanics of the the endoplasmic reticulum associated degradation system (ERAD). I started my lab at the University of Michigan Medical School in September 2017.

    Links
    • Baldridge Lab
    Qualifications
    • Damon Runyon Cancer Research Foundation Fellow
      Harvard Medical School, Cell Biology, 2017
    • PhD
      Vanderbilt University, Nashville, 2013
    • BS
      Northern Kentucky University, Highland Heights, 2007
    • BS
      Northern Kentucky University, Highland Heights, 2007
    Research Overview

    We are interested in the basic mechanisms of protein quality control systems at cellular membranes. We study how these systems select their substrates, and aim to identify the cellular pathways regulated by them. These processes are important in pathologies related to cell stress, protein misfolding, and protein misregulation. Human illnesses linked to these problems include Parkinson’s disease, Alzheimer’s disease, and various cancers. Our longer-term goals are to understand how changing conditions in cells target substrate proteins to these integral-membrane quality control systems and exploit these systems to enable targeted protein degradation from cellular organelles.

    Recent Publications See All Publications
    • Journal Article
      Deep mutational scanning highlights a role for cytosolic regions in Hrd1 function.
      Peterson BG, Hwang J, Russ JE, Schroeder JW, Freddolino PL, Baldridge RD. Cell Rep, 2023 Nov 28; 42 (11): 113451 DOI:10.1016/j.celrep.2023.113451
      PMID: 37980570
    • Preprint
      Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen
      Sharninghausen R, Hwang J, Dennison D, Baldridge RD. 2023 Sep 5; eLife Sciences Publications, Ltd, DOI:10.7554/elife.89606
    • Preprint
      Direct observation of autoubiquitination for an integral membrane ubiquitin ligase in ERAD
      Assainar BM, Ragunathan K, Baldridge R. 2023 bioRxiv, DOI:10.1101/2023.06.20.545802
    • Journal Article
      The ERAD system is restricted by elevated ceramides.
      Hwang J, Peterson BG, Knupp J, Baldridge RD. Sci Adv, 2023 Jan 13; 9 (2): eadd8579 DOI:10.1126/sciadv.add8579
      PMID: 36638172
    • Journal Article
      Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1.
      Peterson BG, Glaser ML, Rapoport TA, Baldridge RD. Elife, 2019 Nov 12; 8: DOI:10.7554/eLife.50903
      PMID: 31713515
    • Journal Article
      Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD.
      Baldridge RD, Rapoport TA. Cell, 2016 Jul 14; 166 (2): 394 - 407. DOI:10.1016/j.cell.2016.05.048
      PMID: 27321670
    • Journal Article
      Type IV P-type ATPases distinguish mono- versus diacyl phosphatidylserine using a cytofacial exit gate in the membrane domain.
      Baldridge RD, Xu P, Graham TR. J Biol Chem, 2013 Jul 5; 288 (27): 19516 - 19527. DOI:10.1074/jbc.M113.476911
      PMID: 23709217
    • Journal Article
      Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases.
      Baldridge RD, Graham TR. Proc Natl Acad Sci U S A, 2013 Jan 29; 110 (5): E358 - E367. DOI:10.1073/pnas.1216948110
      PMID: 23302692
    Featured News & Stories Schematic of Hrd1 proteoliposome immobilization
    Department News
    PhD student Basila Moochickal Assainar publishes a research article in Nature Communications
    PhD student Basila Moochickal Assainar is the first author of a research article in Nature Communications.
    Department News
    Ryan Baldridge, PhD, and Billy Tsai, PhD, receive an award from the W. M. Keck Foundation
    U-M Medical School researchers Ryan Baldridge, PhD, and Billy Tsai, PhD, are recipients of a $1.3 million grant from the W. M. Keck Foundation.
    Department News
    Ryan Baldridge and Billy Tsai received a W.M. Keck Foundation Award
    The W.M. Keck Foundation has awarded $1.3M to Assistant Professor Ryan Baldridge, Biological Chemistry, and Corydon Ford Collegiate Professor Billy Tsai, CDB, to develop a next-generation protein degradation technology to revolutionize antiviral treatments for endoplasmic reticulum (ER) dysfunction.
    Department News
    Evan Arnold receives UMMS Master's Program Graduate Student Award
    Evan Arnold has received a UMMS Master's Program Graduate Student Award.
    Department News
    Baldridge lab publishes research article in Science Advances
    The Baldridge lab publishes a research article in Science Advances