Ursula Jakob, Ph.D.

Patricia S. Yaeger Collegiate Professor, Molecular, Cellular, and Developmental Biology
Professor, Biological Chemistry

5014 BSB
1105 N. University Avenue
Ann Arbor, MI 48109-1085

(734) 615-1286

Areas of Interest

Biochemical aspects of the bacterial response to oxidative stress.

Honors & Awards

Elected Fellow, American Association for the Advancement of Science, 2020
Elected Member, German National Academy of Sciences (Leopoldina), 2020
Elected Member, Bavarian Academy of Sciences and Humanities, 2014
Faculty Recognition Award, University of Michigan, 2011
Biological Sciences Scholar, University of Michigan, 2001
Career Award in the Biomedical Sciences, Burroughs Wellcome Fund, 2000
Sokol Postdoctoral Award, 1998

Published Articles or Reviews

Recent Publications

Depletion of mitochondrial inorganic polyphosphate (polyP) in mammalian cells causes metabolic shift from oxidative phosphorylation to glycolysis.
Solesio ME, Xie L, McIntyre B, Ellenberger M, Mitaishvili E, Bhadra-Lobo S, Bettcher LF, Bazil JN, Raftery D, Jakob U, Pavlov EV.
Biochem J. 2021; 478: 1631–46.

Thiol-based switching mechanisms of stress-sensing chaperones.
Ulrich K, Schwappach B, Jakob U.
Biol Chem. 2020; 402: 239–52.

Mycobacterium tuberculosis Rv0991c Is a Redox-Regulated Molecular Chaperone.
Becker SH, Ulrich K, Dhabaria A, Ueberheide B, Beavers W, Skaar EP, Iyer LM, Aravind L, Jakob U, Darwin KH.
mBio. 2020; 11: e01545-20.

Polyphosphate Functions In Vivo as an Iron Chelator and Fenton Reaction Inhibitor.
Beaufay F, Quarles E, Franz A, Katamanin O, Wholey WY, Jakob U.
mBio. 2020; 11: e01017-20.

Developmental ROS individualizes organismal stress resistance and lifespan.
Bazopoulou D, Knoefler D, Zheng Y, Ulrich K, Oleson BJ, Xie L, Kim M, Kaufmann A, Lee YT, Dou Y, Chen Y, Quan S, Jakob U.
Nature. 2019; 576: 301–5.

Mechanistic insights into the protective roles of polyphosphate against amyloid cytotoxicity.
Lempart J, Tse E, Lauer JA, Ivanova MI, Sutter A, Yoo N, Huettemann P, Southworth D, Jakob U.
Life Sci Alliance. 2019; 2: e201900486.

Polyphosphate Initiates Tau Aggregation through Intra- and Intermolecular Scaffolding.
Wickramasinghe SP, Lempart J, Merens HE, Murphy J, Huettemann P, Jakob U, Rhoades E.
Biophys J. 2019; 117: 717–28.

Chaperone activation and client binding of a 2-cysteine peroxiredoxin.
Teixeira F, Tse E, Castro H, Makepeace KAT, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob U.
Nat Commun. 2019; 10: 659.

For a list of publications from PubMed, click HERE

Web Sites