Victor Vitvitsky, Ph.D.

RESEARCH LAB SPECIALIST SR.

4240 MSRB III

734-764-4461

Areas of Interest

Regulation of metabolic fluxes, specifically in energy and redox metabolism, metabolism of sulfur containing amino acids,links between metabolic pathways and cell physiology in mammalian cells. Mathematical modeling of intracellular metabolic pathways. Targeting of drugs. Using erythrocytes as drug vehicles.

Honors & Awards

1991 R.V.Khokhlov Award (Supervised undergraduate student research and thesis in Lomonosov Moscow State University)

Published Articles or Reviews

Korendyaseva TK, Martinov MV, Dudchenko AM, Vitvitsky VM. Distribution of methionine between cells and incubation medium in suspension of rat hepatocytes. Amino Acids. 2010 Nov;39(5):1281-9.

Vitvitsky V, Witcher M, Banerjee R, Thoene J. The redox status of cystinotic fibroblasts. Mol Genet Metab. 2010 Apr;99(4):384-8.

Martinov MV, Vitvitsky VM, Banerjee R, Ataullakhanov FI. The logic of the hepatic methionine metabolic cycle. Biochim Biophys Acta. 2010 Jan;1804(1):89-96.

Chiku T, Padovani D, Zhu W, Singh S, Vitvitsky V, Banerjee R. H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J Biol Chem. 2009 Apr 24;284(17):11601-12.

Li S, Arning E, Liu C, Vitvitsky V, Hernandez C, Banerjee R, Bottiglieri T, Lin JD. Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha. Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E543-8.

Korendyaseva TK, Kuvatov DN, Volkov VA, Martinov MV, Vitvitsky VM, Banerjee R, Ataullakhanov FI. An allosteric mechanism for switching between parallel tracks in mammalian sulfur metabolism. PLoS Comput Biol. 2008 May 2;4(5):e1000076.

Prudova A, Albin M, Bauman Z, Lin A, Vitvitsky V, Banerjee R. Testosterone regulation of homocysteine metabolism modulates redox status in human prostate cancer cells. Antioxid Redox Signal. 2007 Nov;9(11):1875-81.

Vitvitsky V, Prudova A, Stabler S, Dayal S, Lentz SR, Banerjee R. Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels. Am J Physiol Renal Physiol. 2007 Aug;293(2):F594-600.

Skorokhod O, Kulikova EV, Galkina NM, Medvedev PV, Zybunova EE, Vitvitsky VM, Pivnik AV, Ataullakhanov FI. Doxorubicin pharmacokinetics in lymphoma patients treated with doxorubicin-loaded erythrocytes. Haematologica. 2007 Apr;92(4):570-1.

Vitvitsky V, Thomas M, Ghorpade A, Gendelman HE, Banerjee R. A functional transsulfuration pathway in the brain links to glutathione homeostasis. J Biol Chem. 2006 Nov 24;281(47):35785-93.

Prudova A, Bauman Z, Braun A, Vitvitsky V, Lu SC, Banerjee R. S-adenosylmethionine stabilizes cystathionine β-synthase and modulates redox capacity. Proc Natl Acad Sci USA. 2006 Apr 25;103(17):6489-94.

Prudova A, Martinov MV, Vitvitsky VM, Ataullakhanov FI, Banerjee R. Analysis of pathological defects in methionine metabolism using a simple mathematical model. Biochim Biophys Acta. 2005 Sep 25;1741(3):331-8.

Skorokhod OA, Garmaeva TTs, Vitvitsky VM, Isaev VG, Parovichnikova EN, Savchenko VG, Ataullakhanov FI. Pharmacokinetics of erythrocyte-bound daunorubicin in patients with acute leukemia. Med Sci Monit. 2004 Apr;10(4):PI55-64.

Vitvitsky V, Dayal S, Stabler S, Zhou Y, Wang H, Lentz SR, Banerjee R. Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia. Am J Physiol Regul Integr Comp Physiol. 2004 Jul;287(1):R39-46.

Vitvitsky V, Mosharov E, Tritt M, Ataullakhanov F, Banerjee R. Redox regulation of homocysteine-dependent glutathione synthesis. Redox Rep. 2003;8(1):57-63.

Ataullakhanov FI, Vitvitsky VM. What determines the intracellular ATP concentration. Biosci Rep. 2002 Oct-Dec;22(5-6):501-11.

Vitvitsky VM, Frolova EV, Martinov MV, Komarova SV, Ataullakhanov FI. Anion permeability and erythrocyte swelling. Bioelectrochemistry. 2000 Dec;52(2):169-77.

Martinov MV, Vitvitsky VM, Mosharov EV, Banerjee R, Ataullakhanov FI. A substrate switch: a new mode of regulation in the methionine metabolic pathway. J Theor Biol. 2000 Jun 21;204(4):521-32.

Martinov MV, Plotnikov AG, Vitvitsky VM, Ataullakhanov FI. Deficiencies of glycolytic enzymes as a possible cause of hemolytic anemia. Biochim Biophys Acta. 2000 Mar 6;1474(1):75-87.