Areas of Interest
My research group is interested in the fundamental questions relevant to the design of vaccines, with a special focus on B cell responses to particulate antigens such as viruses and nanoparticles. Toward a molecular understanding of the underlined mechanisms, we also develop single-molecule and single-particle techniques, and use these techniques to dissect the mechanisms of these processes.
Honors & Awards
2017 Upjohn Research Award, University of Michigan College of Pharmacy
2013 George Fishman Memorial Fund Award, University of Michigan College of Pharmacy
2012 CAREER Award, National Science Foundation
2012 3M Nontenured Faculty Award, 3M
2011 NIH Director's New Innovator Award, National Institutes of Health
2011 Basil O'Connor Starter Scholar Research Award, March of Dimes
2009 Ara G. Paul Assistant Professorship, University of Michigan College of Pharmacy
Quantitation and Stability of Protein Conjugation on Liposomes for Controlled Density of Surface Epitopes.
Chen Z, Moon JJ, Cheng W.
Bioconjug Chem. 2018; 29: 1251-60.
The Single-Molecule Centroid Localization Algorithm Improves the Accuracy of Fluorescence Binding Assays.
Hua B, Wang Y, Park S, Han KY, Singh D, Kim JH, Cheng W, Ha T.
Biochemistry. 2018; 57: 1572-76.
Microfluidic-based high-throughput optical trapping of nanoparticles.
Kotnala A, Zheng Y, Fu J, Cheng W.
Lab Chip. 2017; 17: 2125-34.
Reversible aggregation of HIV-1 Gag proteins mediated by nucleic acids.
Chen Z, Cheng W.
Biochem Biophys Res Commun. 2017; 482: 1437-42.
Multibuilding Block Janus Synthesized by Seed-Mediated Self-Assembly for Enhanced Photothermal Effects and Colored Brownian Motion in an Optical Trap.
Sansanaphongpricha K, DeSantis MC, Chen H, Cheng W, Sun K, Wen B, Sun D.
Small. 2017; 13: 1602569.
Quantitative Correlation between Infectivity and Gp120 Density on HIV-1 Virions Revealed by Optical Trapping Virometry.
DeSantis MC, Kim JH, Song H, Klasse PJ, Cheng W.
J Biol Chem. 2016; 291: 13088-97.
The Density Code for the Development of a Vaccine?
J Pharm Sci. 2016; 105: 3223-32.
For a list of publications, click HERE