Wei Cheng, Ph.D.

Associate Professor, Pharmaceutical Sciences
Associate Professor, Biological Chemistry

3565 C C Little
428 Church Street
Ann Arbor MI  48109-1065


(734) 763-3709

Areas of Interest

My research group is interested in the fundamental questions relevant to the design of vaccines, with a special focus on B cell responses to particulate antigens such as viruses and nanoparticles. Toward a molecular understanding of the underlined mechanisms, we also develop single-molecule and single-particle techniques, and use these techniques to dissect the mechanisms of these processes.

Honors & Awards

2017  Upjohn Research Award, University of Michigan College of Pharmacy
2013  George Fishman Memorial Fund Award, University of Michigan College of Pharmacy
2012  CAREER Award, National Science Foundation
2012  3M Nontenured Faculty Award, 3M
2011  NIH Director's New Innovator Award, National Institutes of Health
2011  Basil O'Connor Starter Scholar Research Award, March of Dimes
2009  Ara G. Paul Assistant Professorship, University of Michigan College of Pharmacy

Published Articles or Reviews

Recent Publications

Quantitation and Stability of Protein Conjugation on Liposomes for Controlled Density of Surface Epitopes.
Chen Z, Moon JJ, Cheng W.
Bioconjug Chem. 2018; 29: 1251-60.

The Single-Molecule Centroid Localization Algorithm Improves the Accuracy of Fluorescence Binding Assays.
Hua B, Wang Y, Park S, Han KY, Singh D, Kim JH, Cheng W, Ha T.
Biochemistry. 2018; 57: 1572-76.

Microfluidic-based high-throughput optical trapping of nanoparticles.
Kotnala A, Zheng Y, Fu J, Cheng W.
Lab Chip. 2017; 17: 2125-34.

Reversible aggregation of HIV-1 Gag proteins mediated by nucleic acids.
Chen Z, Cheng W.
Biochem Biophys Res Commun. 2017; 482: 1437-42.

Multibuilding Block Janus Synthesized by Seed-Mediated Self-Assembly for Enhanced Photothermal Effects and Colored Brownian Motion in an Optical Trap.
Sansanaphongpricha K, DeSantis MC, Chen H, Cheng W, Sun K, Wen B, Sun D.
Small. 2017; 13: 1602569.

Quantitative Correlation between Infectivity and Gp120 Density on HIV-1 Virions Revealed by Optical Trapping Virometry.
DeSantis MC, Kim JH, Song H, Klasse PJ, Cheng W.
J Biol Chem. 2016; 291: 13088-97.

The Density Code for the Development of a Vaccine?
Cheng W.
J Pharm Sci. 2016; 105: 3223-32.

For a list of publications, click HERE

Web Sites