Areas of Interest
Cell fate decisions are controlled by tissue-specific transcription factors acting in concert with epigenetic regulators such as enzymes that carry out histone post-translational modifications. Epigenetic dysregulation emerges as a key characteristic of human malignancies. The Dou lab seeks to determine the epigenetic basis of normal and aberrant embryonic and hematopoietic development. By comparing the ontogeny of gene regulatory networks in embryonic stem cells as well as leukemia stem cells, the lab aims to understand how lineage-specifying transcription factors, non-coding DNA regulatory regions and epigenetic modulating enzymes cooperate to maintain or reprogram stem cell characteristics, expand differentiation potentials, and perturb disease development. These studies promise to not only advance our understanding of the context-specific roles of epigenetic modulators in development and diseases, but also provide critical insights into designing novel target-based therapeutic strategies in cancer treatment and regenerative medicine.
Honors & Awards
2014 Basic Science Research Award, University of Michigan Medical School
2012 Scholar Award, Leukemia & Lymphoma Society
2011 Innovative Research Grant, Stand Up To Cancer
2010 Gertrude B. Elion Cancer Research Award, American Association for Cancer Research
2010 Research Scholar Grant, American Cancer Society
2006 Biological Sciences Scholar, University of Michigan
Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Park SH, Ayoub A, Lee YT, Xu J, Kim H, Zheng W, Zhang B, Sha L, An S, Zhang Y, Cianfrocco MA, Su M, Dou Y, Cho US.
Nat Commun. 2019; 10: 5540.
MLL1 Inhibition and Vitamin D Signaling Cooperate to Facilitate the Expanded Pluripotency State.
Zhang H, Khoa LTP, Mao F, Xu H, Zhou B, Han Y, O'Leary M, Nusrat A, Wang L, Saunders TL, Dou Y.
Cell Rep. 2019; 29: 2659-71
Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.
Zhang Y, Jang Y, Lee JE, Ahn J, Xu L, Holden MR, Cornett EM, Krajewski K, Klein BJ, Wang SP, Dou Y, Roeder RG, Strahl BD, Rothbart SB, Shi X, Ge K, Kutateladze TG.
Nat Commun. 2019; 10: 2314.
Modulating Protein-Protein Interactions with Visible-Light-Responsive Peptide Backbone Photoswitches.
Albert L, Peñalver A, Djokovic N, Werel L, Hoffarth M, Ruzic D, Xu J, Essen LO, Nikolic K, Dou Y, Vázquez O.
Chembiochem. 2019; 20: 1417-29.
HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.
Sun Y, Zhou B, Mao F, Xu J, Miao H, Zou Z, Phuc Khoa LT, Jang Y, Cai S, Witkin M, Koche R, Ge K, Dressler GR, Levine RL, Armstrong SA, Dou Y, Hess JL.
Cancer Cell. 2018; 34: 643-58.
Facile target validation in an animal model with intracellularly expressed monobodies.
Gupta A, Xu J, Lee S, Tsai ST, Zhou B, Kurosawa K, Werner MS, Koide A, Ruthenburg AJ, Dou Y, Koide S.
Nat Chem Biol. 2018; 14: 895-900.
Re-SET for Transcription.
Liu Y, Dou Y.
Mol Cell. 2018; 70: 985-6.
Effects of histone H2B ubiquitylation on the nucleosome structure and dynamics.
Krajewski WA, Li J, Dou Y.
Nucleic Acids Res. 2018; 46: 7631-42.
For a list of publications from Michigan Research Experts, click HERE