Areas of Interest
The goal of the Zhang lab is to understand the fundamental relations between protein sequence, structure and function. The major focus of the lab is to develop new bioinformatics algorithms to predict 3-dimensional protein structure from the amino acid sequence and deduce the biological function of proteins by comparing the predicted structures with the function databases.
A number of computational methods developed by the Zhang lab have been demonstrated in the CASP experiments to be the world's best for protein structure prediction and function annotation. The lab is currently working on extending the developed protein modeling algorithms for protein design and structure-based drug discovery. They are especially interested in modeling G protein-coupled receptors and the interactions with the associated ligands with the purpose of developing new drugs to regulate these interactions ( Read more on Zhang Lab research).
Honors & Awards
2013 Dean's Basic Science Research Award
2008 Alfred P. Sloan Award
2008 NSF Career Award
Srayanta Mukherjee, Yang Zhang. Protein-protein complex structure prediction by multimeric threading and template recombination. Structure, in press (2011).
Andrea Bazzoli, Andrea G. B. Tettamanzi, Yang Zhang. Computational Protein Design and Large-Scale Assessment by I-TASSER Structure Assembly Simulations. Journal of Molecular Biology, vol 407, 764-776 (2011).
Ambrish Roy, Alper Kucukural, Yang Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, vol 5, 725-738 (2010).
Jian Zhang, Yang Zhang. G protein-coupled receptor spatial restraint database for 3-D structure modeling and function annotation Bioinformatics. Bioinformatics, vol 26, 3004-3005 (2010).
Sitao Wu, Yang Zhang. Recognizing Protein Substructure Similarity Using Segmental Threading. Structure, vol 18, 858-867 (2010).
Yang Zhang. Protein structure prediction: when is it useful? Current Opinion in Structural Biology, vol 19, 145-155 (2009).
Srayanta Mukherjee, Yang Zhang. MM-align: a quick algorithm for aligning multiple-chain protein complex structures using iterative dynamic programming. Nucleic Acids Research, vol 37, e83 (2009).
Yang Zhang. I-TASSER: Fully automated protein structure prediction in CASP8. Proteins, vol S9, 100-113 (2009).
Yang Zhang. Progress and challenges in protein structure prediction. Current Opinion in Structural Biology, vol 18, 342-348 (2008).
More of Yang Zhang's Publications, click HERE