The Department of Biological Chemistry in the University of Michigan Medical School educates and trains undergraduate, graduate, post-graduate and medical students in modern biochemistry. Our research areas include biochemical signaling, macromolecular structure and mechanism, protein processing and folding, and regulation of gene expression. Explore our graduate programs and some of the cutting-edge work being performed in the laboratories of our faculty.
Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1
PNAS study reveals the structural mechanisms that enable the protein ZAP to find and capture viral RNA, and offers insights into why some viruses (including HIV) can avoid this antiviral protein.
Itaconyl-CoA Forms a Stable Biradical in Methylmalonyl-CoA Mutase and Derails Its Activity and Repair
The study reveals the molecular details of a key protein-protein interaction that drives cell movement and metastasis.
MMOD-Induced Structural Changes of Hydroxylase in Soluble Methane Monooxygenase
