Congratulations to Bryan Dunyak of the Gestwicki Lab for successfully defending his thesis “Peptidyl-Proline Isomerases: Promising Targets for Natural Product-Inspired Therapeutics”

The enzyme ultimately responsible for biological methane production, methyl-coenzyme M reductase, has an ambiguous mechanism because it involves difficult-to-isolate reaction intermediates. Wongnate et al. used spectroscopic and kinetic methods to trap the key intermediates in the enzyme active site. Experimental and computational methods