Angelo Guilatco

Angelo Guilatco

PIBS 1st-Year Rotating PhD Student

Biography

I graduated from the University of California, Davis in 2014 with a Bachelor of Science in Biotechnology and a minor in Philosophy. As an undergraduate, I worked in the laboratory of Dr. Elizabeth Mitcham studying transcriptional regulation in ripening pears. Following graduation, I worked at Genentech as a biologics manufacturing technician and found an interest in cancer drug development. Since 2016, I have worked at Five Prime Therapeutics as a research associate, first in the Molecular Biology department under the supervision of Dr. Elizabeth Bosch and then as part of the Immuno-Oncology Discovery department under the supervision of Dr. Art Brace and Dr. Andrew Rankin. I contributed to several early discovery programs, including mechanistic studies and antibody characterization for a novel immune checkpoint molecule in collaboration with Bristol-Myers Squibb and a novel tumor-expressed receptor that can be directly targeted to arrest cell proliferation.

In my free time, I enjoy baking cakes, hiking, running, and board gaming. I am also a big fan of escape rooms, with over 60 successful escapes so far (and hopefully more to add in Michigan).

Research Interests

I am interested in studying mechanisms of tumorigenesis and developing potential therapeutic agents that can modulate tumor cell growth and proliferation. I would also like to explore the evolution of intratumoral heterogeneity and the implications it has on durable response to treatment.

Techniques Used

Cell line engineering (stable KO and overexpression), flow cytometry, immunofluorescence, confocal microscopy, live-cell imaging and analysis, ELISA/AlphaLISA, luminescent reporter assays, molecular cloning, RT-qPCR, high-throughput screening

Awards

Citation for Outstanding Performance in Biotechnology (2014)

Diversity Ambassador

First Generation U.S. Citizen