Angelo Guilatco

Angelo Guilatco

Graduate Student

Biography

I graduated from the University of California, Davis in 2014 with a Bachelor of Science in Biotechnology and a minor in Philosophy. As an undergraduate, I worked in the laboratory of Dr. Elizabeth Mitcham studying transcriptional regulation in ripening pears. Following graduation, I worked at Genentech as a biologics manufacturing technician and found an interest in cancer drug development. From 2016-2020, I worked at Five Prime Therapeutics as a research associate, first in the Molecular Biology department under the supervision of Dr. Elizabeth Bosch and then as part of the Immuno-Oncology Discovery department under the supervision of Dr. Art Brace and Dr. Andrew Rankin. I contributed to several early discovery programs, including mechanistic studies and antibody characterization for a novel immune checkpoint molecule in collaboration with Bristol-Myers Squibb and a novel tumor-expressed receptor that can be directly targeted to arrest cell proliferation.

I joined the University of Michigan in 2020 as a rotating graduate student in the Program for Biomedical Sciences (PIBS). I am now part of the Cancer Biology Program and a student in the lab of Dr. Megan Weivoda, where I am researching senescence and tumorigenesis in the bone marrow microenvironment.

In my free time, I enjoy baking cakes, hiking, running, and board gaming. I am also a big fan of escape rooms, with over 60 successful escapes so far (and hopefully more to add in Michigan).

Research Interests

I will be researching how senescence and the senescence-associated secretory phenotype may be driving the progression of pre-malignant monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) to malignant multiple myeloma (MM) in the bone marrow microenvironment. Additionally, I will be researching a class of drugs known as senolytics, which can selectively eliminate senescent cells, to determine their effect on tumorigenesis.

Techniques Used

Cell line engineering (stable KO and overexpression), flow cytometry, immunofluorescence, confocal microscopy, live-cell imaging and analysis, ELISA/AlphaLISA, luminescent reporter assays, molecular cloning, RT-qPCR, high-throughput screening

Awards

Citation for Outstanding Performance in Biotechnology (2014)

Diversity Ambassador

First Generation U.S. Citizen