Dr. Lee received her Ph.D. from New York University, where she investigated the role of the Ras signaling pathway in pancreatic cancer under the mentorship of Dr. Dafna Bar-Sagi. She then went on to perform postdoctoral research in the laboratory of Dr. M. Celeste Simon at the University of Pennsylvania, where she developed a strong interest in the hypoxic tumor microenvironment and oncoimmunology. In September of 2018, Dr. Lee joined the faculty in the Department of Pharmacology at the University of Michigan as an Assistant Professor. Dr. Lee recently received Department of Defense (DoD) Career Development Award and Rogel Cancer Center-Swim Across America Young Investigator Award.
Pancreatic cancer is characterized by an extensive inflammatory, desmoplastic stromal reaction contributing to a hypoxic microenvironment. Our research focuses on understanding how hypoxia modulates tumor-stroma interactions in the pancreas, and thereby developing effective anti-cancer therapies that aim to remodel tumor microenvironment. We use a wide range of approaches, including mouse models and 3D organoid cultures.
Research Opportunities for Rotating Students
Project #1: Explore hypoxic control of tumor-stroma crosstalk.
Project #2: Investigate the roles of B cell subsets in pancreatic tumorigenesis.