Sami Malek, M.D.

I graduated from the University of Hamburg / Germany in 1991 with a medical degree.   I completed a postdoc at Johns Hopkins University Department of Molecular Biology and Genetics from 1992-1997.  This was followed by clinical training in Internal Medicine at Baylor College of Medicine and in Oncology/Hematology at Johns Hopkins Oncology Center, with a brief research stint at Columbia University.  I joint the faculty of the University of Michigan in 2004. 

The lab is studying the basic biology, genomics and targeted therapy of leukemia and lymphoma.  

multiple projects are available

Parkin B, Ouillette P, Li Y, Keller, J., Lam, C., Roulston, D., Li C, Shedden K, Malek, S.N. (2013).  Clonal Evolution and Devolution following chemotherapy in adult acute myelogenous leukemia. Blood 121(2): 369-77. PM23175688/PMC3653567.

Li, H., Kaminski, MS., Li, Y., Yildiz, M., Ouillette, P., S, J., Fox, H., Jacobi, K., Saiya-Cork, K., Bixby, D., Lebovic, D., Roulston, D., Shedden, K., Sabel, M., Marentette, L., Cimmino, V., Chang, AE. and Malek, S.N. (2014). Mutations in linker histone genes HIST1H1 B, C, D and E, OCT2 (POU2F2), IRF8 and ARID1A underlying the pathogenesis of follicular lymphoma. Blood 123(10):1487-98, PM24435047; PMC4729540

Parkin, B., Ouillette, P., Yildiz, M., Saiya-Cork, K., Shedden, K. Malek, S.N. (2015). Integrated genomic profiling, therapy response and survival in adult acute myeloid leukemia. Clinical Cancer Research, 21(9): 2045-56. PM25652455/PMC4417381.

Yildiz, M., Li, H., Bernard, D., Amin, NA, Ouillette, P., Jones, S., Saiya-Cork, K., Parkin, B., Jacobi, K., Shedden, K., Wang, S., Chang, AE., Kaminski, M., Malek, S.N. (2015). Activating STAT6 mutations in follicular lymphoma. Blood. 2015; 125(4):668-679. (See commentary written on this paper in Inside Blood by Dr. Nellapu). Blood. 125(4):587-599.PMC4729538

Amin, N.A., Seymour, S., Saiya-Cork, K., Parkin, B, Shedden, K and Malek, S.N. (2016). A quantitative analysis of subclonal and clonal gene mutations pre- and post-therapy in Chronic Lymphocytic Leukemia.  Clinical Cancer Research, 22(17):4525-4535. PM27060156/ PMC5010528

Amin, N.A., Balasubramanian, S., Saiya-Cork, K., Shedden, K, Hu, N. and Malek, S.N. (2016). Cell-intrinsic determinants of ibrutinib-induced apoptosis in Chronic Lymphocytic Leukemia. Clinical Cancer Research, 23(4):1049-1059. PM27535981/PMC5315657.

Ying, Z.X., Jin, M., Peterson, L.F., Bernard, D., Saiya-Cork, K., Yildiz, M., Wang, S., Kaminski, M.S., Chang, A.E., Klionsky, D.J. and Malek, S.N. (2016). Recurrent mutations in the MTOR regulator RRAGC in follicular lymphoma. Clinical Cancer Research, 22(21): 5383-5393.PMC5093058

Parkin, B., Londono-Joshi, A., Kang, Q., Tewari, M., Rhim, A.D., Malek, S.N. (2017). Ultra-sensitive detection of rare aberrant cells in remission causing AML relapse. Journal of Clinical Investigation. Sep 1;127(9):3484-3495.PMC5569556.

Wang, F., Gatica, D., Ying, ZX., Peterson, LF., Kim, P., Bernard, D., Saiya-Cork, K., Wang, S., Kaminski, MS., Chang, AE., Phillips, T., Klionsky, DJ. and Malek, S.N. (2019). Follicular lymphoma-associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and MTOR. Journal of Clinical Investigation. Mar 4; 130:1626-1640. PMC5093058

Hu, N., Wang, F., Sun, T., Xu, Z., Zhang, J., Bernard, D., Xu, S., Wang, S., Kaminski, MS., Devata, S., Phillips, T. and Malek, S.N. (2021). Follicular lymphoma-associated BTK mutations are inactivating resulting in augmented AKT activation. Clinical Cancer Research, Apr 15;27(8):2301-2313. doi: 10.1158/1078-0432.CCR-20-3741.

Wang, F., Yang, Y., Boudagh, G., Eskelinen, EL., Klionsky, D., and Malek, S.N. (2022):  Follicular lymphoma-associated mutations in the V-ATPase chaperone VMA21 activate autophagy creating a targetable dependency. Autophagy in press Mar 3, 2022. PMID: 35287545.