Stephen Deangelo

Steve is a native of Boston, Massachusetts and completed his undergraduate degree in Biochemistry at Boston College in 2017. His undergraduate research on small molecule bromodomain inhibitors was performed in collaboration with the Dana Farber Cancer Institute in the laboratory of Dr. James (Jay) Bradner, under the mentorship of Dr. Sirano Dhe-Paganon. After receiving his B.S., Steve spent two more years at the Dana Farber as a technician in the laboratories of Dr. Eric Fischer and Dr. Scott Armstrong where he focused on the development of Proteolysis Targeting Chimeras (PROTACs). Steve is now working in the laboratory of Dr. Markos Koutmos where he is studying tRNA modifying enzymes and their ability to regulate the translation of cancer related genes in melanoma.

Outside of the lab Steve loves sports, the outdoors, and cooking, with a recently found pandemic inspired hobby of baking sourdough bread

My research focuses on understanding cancer at a molecular level using X-Ray Crystallography and Enzyme Kinetics. My work in the Koutmos lab is centered around understanding and characterizing the enzymes that modify tRNAs at the U34 wobble position. Furthermore, I seek to evaluate how inhibition of these enzymes could be beneficial in metastatic BRAF(V600E) melanoma.

X-Ray Crystallography, Recombinant Protein Purification, Assay Development, High Throughput Screening, Cell Culture

Nowak R.P., DeAngelo S.L., Buckley D., Donovan K.A., An J., Safaee N., He Z.,
Jedrychowski M., Ponthier C.M., Ishoey M., Zhang T., Mancias J.D., Bradner J.E., Gray N.S.,
Fischer E.S. Plasticity in binding confers selectivity in ligand induced protein degradation
Harvard Department of Cancer Biology Retreat, April 2018

Nowak R.P., DeAngelo S.L., Buckley D., Donovan K.A., An J., Safaee N., He Z., Jedrychowski
M., Ponthier C.M., Ishoey M., Zhang T., Mancias J.D., Bradner J.E., Gray N.S., Fischer E.S.
Achieving single protein specificity with BET-family degraders. Harvard Department of
Biological Chemistry and Molecular Pharmacology (BCMP) retreat, October 2017

Nowak R.P., DeAngelo S.L., Buckley D., Donovan K.A., An J., Safaee N., He Z., Jedrychowski
M., Ponthier C.M., Ishoey M., Zhang T., Mancias J.D., Bradner J.E., Gray N.S., Fischer E.S.
Ubiquitin E3 ligase-substrate contacts confer selectivity to heterobifunctional degraders. Boston College Undergraduate Research Fair, April 2017

https://www.ncbi.nlm.nih.gov/myncbi/stephen.deangelo.1/bibliography/public/