Deborah Gumucio

James Douglas Engel Collegiate Professor
Research Focus: Hedgehog signaling, morphogenesis, epithelial-mesenchymal interactions, lumen formation, cell polarity

3071 BSRB 
109 Zina Pitcher Place
Ann Arbor MI 48109-2200

734-647-0172

Areas of Interest

One project is centered on development and homeostasis of the intestine:  How does the intestine develop in the embryo? What factors account for its tremendous longitudinal growth? What signaling mechanisms underlie the formation of the intestinal villi (fingerlike projections that establish the enormous absorptive surface)? In adults, how does Hedgehog signaling modify inflammation in the intestine?

A second project grows from our recent discovery that single dissociated human pluripotent stem cells form apically polarized lumens upon the first cell division:  What cellular machinery is responsible for this lumenogenesis phenomenon? How is lumenogenesis initiated? Does this event reflect the early formation of the epiblast cavity? Is this event relevant to organoid formation?

Associated Grad Programs

Cell & Developmental Biology, Cellular & Molecular BiologyBioInformaticsMSTP

Credentials

  • University of Michigan, Ph.D., 04/1986 
  • University of Michigan, M.P.H., 07/1975 
  • University of Michigan, B.A., 04/1971

Published Articles or Reviews

My work has been published as Miller, DL and as Gumucio D. Full links to both are provided here:

http://www.ncbi.nlm.nih.gov/pubmed/?term=Miller+DL%2C+Gumucio  (10 publications)

http://www.ncbi.nlm.nih.gov/pubmed/?term=Gumucio+D (96 publications)