Areas of Interest
Inside every cell, motor proteins move diverse cargos over a set of highly connected "railroad tracks"composed of microtubules. How do motors choose the proper cargo? How do they generate force and directed motion? How do they choose tracks that lead to specific cellular destinations such as the growth cone of an axon?
Associated Grad Programs
Cell & Developmental Biology, Cellular & Molecular Biology, Biophyics
Featured Publications
Budaitis BG*, Jariwala S*, Reinemann DN*, Schimert KI, Scarabelli G, Grant BJ, Sept D, Lang MJ, and Verhey KJ. (2019). Neck linker docking is critical for Kinesin-1 force generation in cells but at a cost to motor speed and processivity. Elife 8: e44146. PMCID: PMC6533058
Engelke MF, Waas B, Kearns SE, Suber A, Boss A, Allen BL, and Verhey KJ. (2019). Acute inhibition of heterotrimeric kinesin-2 function reveals mechanisms of intraflagellar transport in mammalian cilia. Curr Biol. 29(7):1137-1148. PMCID:PMC6445692
Takao D, Dishinger JF, Kee HL, Pinskey JM, Allen BL, and Verhey KJ. (2014). An assay for clogging the ciliary pore complex distinguishes mechanisms of cytosolic and membrane protein entry. Current Biology. 24(19): 2288-2294. PMCID: PMC4189977
Kee HL, Dishinger JF, Blasius TL, Liu CJ, Margolis B, and Verhey KJ. (2012). A size-exclusion barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia. Nature Cell Biology14(4): 431-437. PMCID: PMC3319646
Cai D, McEwen D, Martens JR, Meyhofer E, and Verhey KJ. (2009). Single Molecule Imaging RevealsDifferences in Microtubule Track Selection by Kinesin Motors. PLoS Biology 7: e1000216. PMCID:PMC2749942.
Credentials
- Harvard Medical School, Postdoctoral, 07/2002
- Harvard University, Ph.D., 05/1995
- University of Michigan, B.S., 05/1987