November 22, 2022

The unique way this virus sneaks into a cell’s nucleus could advance the study of cancer-causing pathogens

M Health Lab Report featuring Chelsey Spriggs, Ph.D.

...A study from a team at U-M Medical School takes a closer look at a virus that causes tumors in monkeys, called SV40. SV40 is a DNA virus that, in order to make more of itself, burrows into a cell and then into its nucleus, thereby infecting it.

“SV40 is used as a tool for understanding how viruses that cause cancer in humans work,” said Chelsey Spriggs, Ph.D., assistant professor, Cell & Developmental Biology and Microbiology & Immunology at U-M Medical School, Research Assistant Professor at the U-M Life Sciences Institute, and first author of the study. Several viruses have been tied to cancer in people, including human papillomavirus, Kaposi Sarcoma-associated Herpesvirus and Epstein-Barr virus...