Areas of Interest
We work on the signaling of leukemic stem cells (LSC) with the goal of developing novel therapies to target LSCs. We use mouse models and human leukemia samples to identify the intrinsic and extrinsic mechanisms by which oncogenes and tumor suppressor genes transform normal hematopoietic stem cells and progenitors into LSCs. We are developing and testing novel therapies in these models to eliminate LSCs.