Areas of Interest
My lab's general interests involve understanding how hair follicles develop and how basal cell carcinoma arises in the skin. In terms of development, we are specifically focused on the biology of the hair follicle infundibulum, a poorly characterized domain that constitutes the hair follicle opening, or the pores visible on the surface of the skin. We are interested in the cellular events that generate this opening, the genes that maintain its normal function, as well as events associated with hair canal disruption, which occurs in acne patients. We are interested in studying the stem cells in the skin which give rise to basal cell carcinoma, as well as their interactions with neighboring stomal cells. We are also currently investigating how these tumors regress in response to therapy, as well as how they potentially develop drug resistance.