Using biochemical and microscopy approaches with cell culture and mouse models, I am fascinated to reveal nuclear Keratin’s role in DNA damage response mechanisms.
Genetic basis of therapeutic resistance in glioblastoma and identification of therapeutic targets that reverses resistance to standard of care therapies.
Molecular mediators of stress and anxiety; regulation and role of CRH, the CRH receptors and CRH-binding protein in stress; mechanisms of transcriptional regulation; transgenic mice.
Our lab studies mechanisms of DNA repair and how aberrant repair processes affect genomic stability, predisposition to cancer and immune system development.
The major goal of our research program is to determine the molecular mechanisms by which oxygen sensing transcription factors regulate gastrointestinal homeostasis, inflammation and cancer.
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Research Interests:
Research in the Singer lab is focused on understanding the influence of diet-induced obesity on hematopoiesis and the generation of activated macrophages that lead to metabolic disease.