mechanism by which overepression of EZH2 and down-regulation of CCN6 (WISP3) promote breast cancer invasion and metastasis, and their utility as novel tissue biomarkers of prognosis.
Experimental research activities directed at understanding the cellular and molecular mechanisms of cytokine networks that are operative in different immune/inflammatory reactions and host defenses
Understand how pancreatic cancer develops in complex tissue environments, with particular interest in hypoxia and immune cells as critical tumor microenvironment components
My group studies the genetic basis of complex human diseases. Current areas include genetic and genomic analyses of mental disorders, somatic DNA alterations in cancer, and human population genetics.
Interaction between retroviruses and human cellular proteins. Mechanism of action of the DEK oncoprotein. Role of vimentin in immunity and cancer. Kaposi’s Sarcoma.