Developing a device to simultaneously measure NADH generation and oxygen consumption in mitochondria in order to investigate the role of metabolic intermediates in bioenergetics.
Using cell lines and neuronal models to investigate molecular mechanisms of Ubiquilin-2 (UBQLN2) regulation in normal cellular function and ALS caused by UBQLN2 mutations.
Using biochemical and microscopy approaches with cell culture and mouse models, I am fascinated to reveal nuclear Keratin’s role in DNA damage response mechanisms.