Our research program focuses on the structural biology and biophysics underlying microtubule-based intracellular transport through the use of cryo-electron microscopy, single molecule TIRF, and biochemistry.
Overarching questions of the lab: How is specificity determined between motor proteins and cargo? How are the activities of multi-motor complexes regulated? What are the molecular consequences of neurodegenerative disease-causing mutations?
Along the way, we are also developing cloud computing tools for cryo-electron microscopy to facilitate its adoption and to remove barriers for new users.
I am committed to training and educating a diverse cadre of students, post-doctoral fellows, and researchers to build a diverse community of scientists that will be able to tackle the challenges of the 21st century.