Research Interests
Medulloblastoma (MB) and glioblastoma (GBM) are the most common malignant brain tumors in children and adults, respectively. There is accumulated evidence showing that a small population of cancer stem cells (CSCs) within cancers is responsible for tumor propagation, including MB and GBM. Our goal is to develop novel therapies for the malignant brain tumors MB and GBM based on the depletion of CSCs. We have demonstrated recently that Notch pathway inhibition depletes CSCs and blocks engraftment of MB and GBM cells.