Wednesday, September 7, 2016

"Ontology – Having relationship is a complicated thing"

3:30 PM to 4:30 PM

Forum Hall, 4th Floor, Palmer Commons Building

CCMB Seminar Series – sponsored by DCMB

by Dr. Sirarat Sarntivijai,
European Bioinformatics Institute (EMBL-EBI)

Abstract

Specific domain ontologies have been successfully established under the consortium umbrella such as the OBO Foundry. These range from cellular level (e.g., Gene Ontology, Cell Ontology, Cell Line Ontology) all the way up to organism level (e.g., UBERON, NCBI Taxon), and clinical observations (e.g., Mouse Phenotype Ontology, Human Phenotype Ontology, Disease Ontology). However, the biological questions being asked in research query across different domain ontologies. This requires the integration of heterogeneous big data, and linking all these different domain ontologies together. Application ontology such as the Experimental Factor Ontology (EFO) has successfully bridged the various components to each other with ontological relationships as showcased in the Open Targets project (http://www.opentargets.org), and the FDA-initiated drug safety framework of PredicTOX.