1. Discuss the conceptual distinction and clinical utility of self-reported race/ethnicity and genetic ancestry in childhood asthma.
2. Discuss the role of genetic ancestry and socio-environmental exposures in childhood asthma.
3. Discuss ancestry-specific polygenic risk scores, precision medicine and childhood asthma disparities.
Dr. Mersha is currently an Associate Professor in the Division of Asthma Research and leads the Population Genetics, Ancestry, and Bioinformatics (pGAB) Laboratory (https://research.cchmc.org/mershalab/Home.php).
Dr. Mersha’s research combines quantitative, ancestry and statistical genomics to unravel genetic and non-genetic contributions to complex diseases and racial disparities in human populations, particularly asthma and asthma-related allergic disorders. Much of his research is at the interface of genetic ancestry, statistics, bioinformatics, and functional genomics, and he is interested in cross-line disciplines to unravel the interplay between genome and envirome underlying asthma risk. His long-term research goal is to understand and dissect how biologic predisposition and environmental exposures interact to shape racial disparities in complex disorders.